Microfluidic System for Drug Delivery Based on Microneedle Array and IPMC Valveless Pump

2021 ◽  
Author(s):  
Kamil G. Gareev ◽  
Ivan K. Khmelnitskiy ◽  
Ivan V. Mandrik ◽  
Yuriy D. Orekhov ◽  
Dmitry O. Testov
Keyword(s):  
Drug Delivery ◽  
Microfluidic System ◽  
Microneedle Array ◽  
Valveless Pump

scholarly journals Design and Analyses of a Transdermal Drug Delivery Device (TD3) †

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5090 ◽  
Author(s):  
Jennifer García ◽  
Ismael Ríos ◽  
Faruk Fonthal Rico
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Computer Aided Design ◽  
Micro Electro Mechanical System ◽  
Discharge Process ◽  
Microneedle Array ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Computational Fluid Dynamics Cfd ◽  
Aided Design

In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

Development of cup shaped microneedle array for transdermal drug delivery

2015 ◽  
Vol 10 (2) ◽  
pp. 021008 ◽  
Author(s):  
Kadayar B. Vinayakumar ◽  
Gopal M. Hegde ◽  
Subbaraya G. Ramachandra ◽  
Mangalore M. Nayak ◽  
Narasimhian S. Dinesh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Microneedle Array

scholarly journals A Three-Dimensional Enormous Surface Area Aluminum Microneedle Array with Nanoporous Structure

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Po Chun Chen ◽  
Sheng Jen Hsieh ◽  
Chien Chon Chen ◽  
Jun Zou
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
3D Structure ◽  
Three Dimensional ◽  
Sensitive Detection ◽  
Nanoporous Structure ◽  
Microneedle Array ◽  
Highly Sensitive ◽  
Technology Applications ◽  
Highly Sensitive Detection

We proposed fabricating an aluminum microneedle array with a nanochannel structure on the surface by combining micromachining, electrolyte polishing, and anodization methods. The microneedle array provides a three-dimensional (3D) structure that possesses several hundred times more surface area than a traditional nanochannel template. Therefore, the microneedle array can potentially be used in many technology applications. This 3D microneedle array device can not only be used for painless injection or extraction, but also for storage, highly sensitive detection, drug delivery, and microelectrodes. From the calculation we made, the microneedle array not only increases surface area, but also enlarges the capacity of the device. Therefore, the microneedle array can further be used on many detecting, storing, or drug delivering applications.

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