A Three-Dimensional Enormous Surface Area Aluminum Microneedle Array with Nanoporous Structure

We proposed fabricating an aluminum microneedle array with a nanochannel structure on the surface by combining micromachining, electrolyte polishing, and anodization methods. The microneedle array provides a three-dimensional (3D) structure that possesses several hundred times more surface area than a traditional nanochannel template. Therefore, the microneedle array can potentially be used in many technology applications. This 3D microneedle array device can not only be used for painless injection or extraction, but also for storage, highly sensitive detection, drug delivery, and microelectrodes. From the calculation we made, the microneedle array not only increases surface area, but also enlarges the capacity of the device. Therefore, the microneedle array can further be used on many detecting, storing, or drug delivering applications.

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Development of micropillar array electrodes for highly sensitive detection of biomarkers

RSC Advances ◽

10.1039/d0ra07694e ◽

2020 ◽

Vol 10 (67) ◽

pp. 41110-41119

Author(s):

Chaozhan Chen ◽

Bin Ran ◽

Zhenxing Wang ◽

Hongli Zhao ◽

Minbo Lan ◽

...

Keyword(s):

Surface Modification ◽

Surface Area ◽

High Sensitivity ◽

Sensitive Detection ◽

Highly Sensitive ◽

Detection Of Biomarkers ◽

Highly Sensitive Detection ◽

Micropillar Array

PDMS-based micropillar array electrodes with increased surface area and surface modification were developed to detect biomarkers with high sensitivity.

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One-step fabrication of electrochemical biosensor based on DNA-modified three-dimensional reduced graphene oxide and chitosan nanocomposite for highly sensitive detection of Hg(II)

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2015.11.091 ◽

2016 ◽

Vol 225 ◽

pp. 453-462 ◽

Cited By ~ 48

Author(s):

Zhihong Zhang ◽

Xiaoming Fu ◽

Kunzhen Li ◽

Ruixue Liu ◽

Donglai Peng ◽

...

Keyword(s):

Graphene Oxide ◽

Reduced Graphene Oxide ◽

Electrochemical Biosensor ◽

Three Dimensional ◽

Sensitive Detection ◽

Reduced Graphene ◽

Highly Sensitive ◽

One Step ◽

Highly Sensitive Detection

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Membrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related Biomarkers

Sensors ◽

10.3390/s18092933 ◽

2018 ◽

Vol 18 (9) ◽

pp. 2933 ◽

Cited By ~ 2

Author(s):

Hye Kim ◽

Shinobu Sato ◽

Shigeori Takenaka ◽

Min-Ho Lee

Keyword(s):

Type I Collagen ◽

Three Dimensional ◽

Sensitive Detection ◽

Type I ◽

Electrochemical Immunoassay ◽

Nylon Membrane ◽

Standard Equipment ◽

Highly Sensitive ◽

Highly Sensitive Detection

Highly sensitive and multiplexed in vitro detection of osteoporosis-related biochemical markers were carried out based on the membrane-based microwave-mediated electrochemical immunoassay (MMeEIA), where we can dramatically reduce the sample preparation time by shortening the incubation time of conjugation to obtain sensitive detection based on three dimensional conjugation of antibodies with target antigens in nylon membrane disk. C-terminal cross-linked telopeptide of type I collagen (CTx), Osteocalcin (OC), parathyroid hormone (PTH), and N-terminal propeptide of type I collagen (P1NP), which can be utilized to monitor the progress of osteoporosis, were quantified using their corresponding antibody immobilized in membranes. Coefficient of variations in this intra- and inter-assays were within 8.0% for all markers. When compared with data obtained from clinically used standard equipment (Roche modular E170), their coefficients of determination, R2 values, are mostly more than 0.9. They show that the results obtained from MMeEIA are in good agreement with that from the conventional clinical instruments.

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Facile synthesis of 3D porous nitrogen-doped graphene as an efficient electrocatalyst for adenine sensing

RSC Advances ◽

10.1039/c6ra01864e ◽

2016 ◽

Vol 6 (37) ◽

pp. 31565-31573 ◽

Cited By ~ 21

Author(s):

Junhua Li ◽

Jianbo Jiang ◽

Haibo Feng ◽

Zhifeng Xu ◽

Siping Tang ◽

...

Keyword(s):

Low Cost ◽

Three Dimensional ◽

Sensitive Detection ◽

Facile Synthesis ◽

Nitrogen Doped ◽

Highly Sensitive ◽

Nitrogen Doped Graphene ◽

Doped Graphene ◽

Highly Sensitive Detection ◽

Convenient Preparation

We demonstrate a simple, low-cost and eco-friendly strategy for the convenient preparation of three-dimensional porous nitrogen-doped graphene (3D-N-GN) for the highly sensitive detection of adenine.

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