Progress Towards Modeling Ship/Aircraft Dynamic Interface

Author(s):  
Susan Polsky
Keyword(s):  
1984 ◽  
Author(s):  
S. L. Madey ◽  
J. C. Petz
Keyword(s):  

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenbin Wei ◽  
Jessica L. Faubel ◽  
Hemaa Selvakumar ◽  
Daniel T. Kovari ◽  
Joanna Tsao ◽  
...  

AbstractTailoring interfaces with polymer brushes is a commonly used strategy to create functional materials for numerous applications. Existing methods are limited in brush thickness, the ability to generate high-density brushes of biopolymers, and the potential for regeneration. Here we introduce a scheme to synthesize ultra-thick regenerating hyaluronan polymer brushes using hyaluronan synthase. The platform provides a dynamic interface with tunable brush heights that extend up to 20 microns – two orders of magnitude thicker than standard brushes. The brushes are easily sculpted into micropatterned landscapes by photo-deactivation of the enzyme. Further, they provide a continuous source of megadalton hyaluronan or they can be covalently-stabilized to the surface. Stabilized brushes exhibit superb resistance to biofilms, yet are locally digested by fibroblasts. This brush technology provides opportunities in a range of arenas including regenerating tailorable biointerfaces for implants, wound healing or lubrication as well as fundamental studies of the glycocalyx and polymer physics.


2014 ◽  
Vol 30 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Yael Elbaz-Alon ◽  
Eden Rosenfeld-Gur ◽  
Vera Shinder ◽  
Anthony H. Futerman ◽  
Tamar Geiger ◽  
...  
Keyword(s):  

Author(s):  
Laura Mosteo ◽  
Joanna Storer ◽  
Kiran Batta ◽  
Emma J. Searle ◽  
Delfim Duarte ◽  
...  

Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.


2008 ◽  
Vol 72 (1) ◽  
pp. 7-10 ◽  
Author(s):  
S. P. Anderson ◽  
R. C. Bales ◽  
C. J. Duffy

AbstractWe live at the dynamic interface between the solid Earth and its outer fluid envelopes. This interface, extending from the outer vegetation canopy to the base of active groundwater, was recently named the Critical Zone because it supports life and is increasingly impacted by human actions. Understanding the complex interactions between processes that operate in and shape the Critical Zone requires interdisciplinary approaches that span wide spatial and temporal scales. Tectonic processes, weathering, fluid transport, and biological processes control the function and structure of the Critical Zone. Three Critical Zone Observatories recently established by the U.S. National Science Foundation are designed to integrate studies of process interactions up to the watershed scale. A goal of the program is to build the three independently conceived observatories into a network from which broader understanding — larger spatial scales but also deeper insight — can emerge.


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