Basic research on the fuse element pattern changing a current pathway in the process of current interruption

2013 ◽  
Author(s):  
Masaki Tsuchiya ◽  
Yasushi Yamano ◽  
Shinichi Kobayashi ◽  
Kengo Hirose
Keyword(s):  
Basic Research ◽  
Current Interruption ◽  
Element Pattern ◽  
Current Pathway ◽  
A Current

The Use of 3D Scanning and 5-Axis Machining in Design and Fabrication of Dental Bridge

2016 ◽  
Vol 834 ◽  
pp. 28-33 ◽  
Author(s):  
Ján Milde ◽  
Ladislav Morovič
Keyword(s):  
Machine Tools ◽  
Basic Research ◽  
3D Scanning ◽  
Dental Restorations ◽  
Cad Cam ◽  
Current Article ◽  
The Subject ◽  
Subsequent Modification ◽  
A Current ◽  
Dental Technology

Dental restorations are currently produced mainly by conventional dental technology methods. The automation of the manufacturing process can be achieved by the use of CAD/CAM technology. Basic research on the most important aspects of CAD/CAM fixed dental restorations from the viewpoint of production, information technology, and dentistry/dental technology are the subject of a current article. The aim of this article is practical using of computer aided technologies such as 3D scanning and 5-axis machining for designing and fabrication of dental restorations. It further explains the detailed process of acquiring a digital description of tooth’s shape and its subsequent modification. Attention is drawn to a detailed analysis of dental restorations’ design obtained from a digital description of a tooth in Cercon Art software. The last part of this paper concentrates on the fabrication of dental restorations, which took place at CAD/CAM dental centre in Bratislava, Slovakia. The fabrication was accomplished by 5-axis kinematic structure of machine tools.

Calcineurin inhibitors: status quo and perspectives

2011 ◽  
Vol 2 (1-2) ◽  
pp. 65-78 ◽  
Author(s):  
Frank Erdmann ◽  
Matthias Weiwad
Keyword(s):  
Calcineurin Inhibitor ◽  
Biological Effects ◽  
Calcineurin Inhibitors ◽  
Basic Research ◽  
Status Quo ◽  
The Past ◽  
Compound Libraries ◽  
High Incidence ◽  
A Current ◽  
Structure Properties

AbstractDespite the fact that cyclosporin A (CsA) and tacrolimus (FK506) are very potent drugs in the treatment of serious autoimmune diseases and in the prevention of graft vs. host reactions or tissue rejections after allo- or xenotransplantations, modern transplantation medicine attempts to develop alternative medication regimes without these calcineurin inhibitors. The primary motivation for this endeavor is the high incidence of dramatic side effects upon immunosuppressive therapy. CsA and FK506 target not only the calcineurin/NFAT pathway, but they also bind and inhibit members of distinct peptidyl-prolyl cis/trans isomerase families, which are involved in numerous important signal transduction pathways. Therefore, the development of a potent calcineurin inhibitor that discriminates between calcineurin and other protein phosphatases and peptidyl-prolyl cis/trans isomerases, respectively, should improve the drug safety in clinical use and represent a valuable tool in basic research to investigate calcineurin modulated pathways. This review gives a current overview about novel calcineurin inhibitors, which were identified by screening of compound libraries and in natural materials or were derived from known inhibitors in the past decades. Thereby, we focus on their structure, properties and biological effects.

scholarly journals A Novel Current Pathway Parallel to the Central Pore in a Mutant Voltage-gated Potassium Channel

2011 ◽  
Vol 286 (22) ◽  
pp. 20031-20042 ◽  
Author(s):  
Sylvia Prütting ◽  
Stephan Grissmer
Keyword(s):  
Voltage Sensor ◽  
High Potassium ◽  
Α Subunit ◽  
Inward Current ◽  
Voltage Gated ◽  
Ion Conducting ◽  
Membrane Spanning ◽  
Voltage Sensing Domain ◽  
Current Pathway ◽  
A Current

Voltage-gated potassium channels are proteins composed of four subunits consisting of six membrane-spanning segments S1–S6, with S4 as the voltage sensor. The region between S5 and S6 forms the potassium-selective ion-conducting central α-pore. Recent studies showed that mutations in the voltage sensor of the Shaker channel could disclose another ion permeation pathway through the voltage-sensing domain (S1–S4) of the channel, the ω-pore. In our studies we used the voltage-gated hKv1.3 channel, and the insertion of a cysteine at position V388C (Shaker position 438) generated a current through the α-pore in high potassium outside and an inward current at hyperpolarizing potentials carried by different cations like Na+, Li+, Cs+, and NH4+. The observed inward current looked similar to the ω-current described for the R1C/S Shaker mutant channel and was not affected by some pore blockers like charybdotoxin and tetraethylammonium but was inhibited by a phenylalkylamine blocker (verapamil) that acts from the intracellular side. Therefore, we hypothesize that the hKv1.3_V388C mutation in the P-region generated a channel with two ion-conducting pathways. One, the α-pore allowing K+ flux in the presence of K+, and the second pathway, the σ-pore, functionally similar but physically distinct from the ω-pathway. The entry of this new pathway (σ-pore) is presumably located at the backside of Y395 (Shaker position 445), proceeds parallel to the α-pore in the S6–S6 interface gap, ending between S5 and S6 at the intracellular side of one α-subunit, and is blocked by verapamil.

Resolving Crystallites in Zirconium Oxide Films

1969 ◽  
Vol 27 ◽  
pp. 140-141
Author(s):  
R.A. Ploc
Keyword(s):  
Electron Microscope ◽  
Inelastic Scattering ◽  
Zirconium Oxide ◽  
Oxide Films ◽  
Optic Axis ◽  
Objective Lens ◽  
Microscope Objective ◽  
Linear Optic ◽  
A Current ◽  
Microscope Objective Lens

The optic axis of an electron microscope objective lens is usually assumed to be straight and co-linear with the mechanical center. No reason exists to assume such perfection and, indeed, simple reasoning suggests that it is a complicated curve. A current centered objective lens with a non-linear optic axis when used in conjunction with other lenses, leads to serious image errors if the nature of the specimen is such as to produce intense inelastic scattering.

Structure of Palladium Single-Crystal Films Prepared by Flash Evaporation onto (001) NaCl Substrates

1970 ◽  
Vol 28 ◽  
pp. 456-457
Author(s):  
L. E. Murr ◽  
G. Wong
Keyword(s):  
Single Crystal ◽  
High Vacuum ◽  
Ultra High Vacuum ◽  
High Rate ◽  
Flash Evaporation ◽  
Optimum Load ◽  
Single Crystal Films ◽  
Crystal Films ◽  
A Current

Palladium single-crystal films have been prepared by Matthews in ultra-high vacuum by evaporation onto (001) NaCl substrates cleaved in-situ, and maintained at ∼ 350° C. Murr has also produced large-grained and single-crystal Pd films by high-rate evaporation onto (001) NaCl air-cleaved substrates at 350°C. In the present work, very large (∼ 3cm2), continuous single-crystal films of Pd have been prepared by flash evaporation onto air-cleaved (001) NaCl substrates at temperatures at or below 250°C. Evaporation rates estimated to be ≧ 2000 Å/sec, were obtained by effectively short-circuiting 1 mil tungsten evaporation boats in a self-regulating system which maintained an optimum load current of approximately 90 amperes; corresponding to a current density through the boat of ∼ 4 × 104 amperes/cm2.

A New 1,000 kV Electron Microscope

1967 ◽  
Vol 25 ◽  
pp. 260-261
Author(s):  
M. Nishigaki ◽  
S. Katagiri ◽  
H. Kimura ◽  
B. Tadano
Keyword(s):  
Electron Microscope ◽  
High Voltage ◽  
Basic Research ◽  
Chromatic Aberration ◽  
High Accuracy ◽  
Biological Specimen ◽  
Voltage Electron ◽  
High Voltage Electron Microscope ◽  
High Voltage Electron

The high voltage electron microscope has many advantageous features in comparison with the ordinary electron microscope. They are a higher penetrating efficiency of the electron, low chromatic aberration, high accuracy of the selected area diffraction and so on. Thus, the high voltage electron microscope becomes an indispensable instrument for the metallurgical, polymer and biological specimen studies. The application of the instrument involves today not only basic research but routine survey in the various fields. Particularly for the latter purpose, the performance, maintenance and reliability of the microscope should be same as those of commercial ones. The authors completed a 500 kV electron microscope in 1964 and a 1,000 kV one in 1966 taking these points into consideration. The construction of our 1,000 kV electron microscope is described below.

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