This chapter proposes the combination of system health monitoring with control and prognosis creating a new paradigm, the health-aware control (HAC) of systems. In this paradigm, the information provided by the prognosis module about the component system health should allow the modification of the controller such that the control objectives will consider the system’s health. In this way, the control actions will be generated to fulfill the control objectives, and, at the same time, to extend the life of the system components. HAC control, contrarily to fault-tolerant control (FTC), adjusts the controller even when the system is still in a non-faulty situation. The prognosis module, with the main feature system characteristics provided by condition monitoring, will estimate on-line the component aging for the specific operating conditions. In the non-faulty situation, the control efforts are distributed to the system based on the proposed health indicator. An example is used throughout the chapter to illustrate the ideas and concepts introduced.