Non-Invasive Imaging of Small-Animal Tumors: High-Frequency Ultrasound vs. MicroPET

2005 ◽  
Author(s):  
Ai-Ho Liao ◽  
Chen-Han Li ◽  
Pai-Chi Li ◽  
Weng-Fang Cheng
Keyword(s):  
High Frequency ◽  
Small Animal ◽  
High Frequency Ultrasound ◽  
Non Invasive ◽  
Frequency Ultrasound

High‐frequency ultrasound as a non‐invasive tool in predicting early hidradenitis suppurativa fistulization in comparison with the Hurley system

2020 ◽  
Author(s):  
Izelda Maria Carvalho Costa ◽  
Camille Bresolin Pompeu ◽  
Eduardo Botelho Silva Mauad ◽  
Mariana Carvalho Costa ◽  
Vanessa Guimarães de Freitas Lima ◽  
...  
Keyword(s):  
High Frequency ◽  
Hidradenitis Suppurativa ◽  
High Frequency Ultrasound ◽  
Non Invasive ◽  
Frequency Ultrasound

scholarly journals P164 Can non-invasive techniques be used to image calcinosis?

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Tonia L Moore ◽  
Elizabeth Marjanovic ◽  
Joanne B Manning ◽  
Graham Dinsdale ◽  
Sarah Wilkinson ◽  
...  
Keyword(s):  
High Frequency ◽  
Significant Proportion ◽  
Laser Speckle ◽  
Adjacent Area ◽  
High Frequency Ultrasound ◽  
Laser Speckle Imaging ◽  
Speckle Imaging ◽  
Non Invasive ◽  
Invasive Techniques ◽  
Frequency Ultrasound

Abstract Background A significant proportion of patients with systemic sclerosis (SSc, 20-40%) will develop subcutaneous calcinotic deposits which are painful and can perforate the skin, causing ulceration. The underlying aetiology is unknown and there is currently no effective treatment. Diagnosis is often made with plain radiography, which is not ideal for long-term monitoring. Identifying non-invasive techniques which do not involve ionising radiation will improve our understanding of calcinosis and how to monitor this over time, facilitating the development of potential treatments. The aim of this study was to assess several non-invasive imaging techniques to measure oxygenation (multispectral imaging), perfusion (thermography [a pseudo measure of perfusion] and laser speckle imaging) and size and depth (high frequency ultrasound) of the calcinoses. The hypothesis of the study was that there would be relationships between oxygenation, perfusion and calcinosis size and depth. Methods Twenty-one patients with SSc (all female, median age 63 (IQR 55 to 70) years; disease duration since onset of first non-Raynaud’s feature 14 (9 to 23) years, Raynaud’s phenomenon duration 23 (12- 36) years; underwent imaging of calcinosis. Measurements of oxygenation, perfusion and vessel size and depth were performed at the site of calcinosis and adjacent skin. Results There was no difference in oxygenation at the site of calcinosis vs adjacent median 0.15 (IQR 0.07 to 0.22) vs. 0.16 (0.00 to 0.21) arbitrary units respectively; non-significant. There was a trend for skin temperature (perfusion) to be lower at the site of the calcinosis compared to the adjacent area (calcinosis, 31.4 (28.4 to 35.6) vs adjacent 32.8 (28.4 to 35.7) oC; p = 0.052. Perfusion as measured by speckle imaging was significantly reduced 107.3 [60.3 to 213.4] vs 312.1 [107.8 to 432.2] arbitrary perfusion units; p < 0.01. The mean depth of the calcinoses was 1.5 (1.11 to 2.07) cm and mean lesion area was 3.06 (2.33 to 4.62) cm2. No relationships were identified between perfusion, oxygenation or calcinosis depth and area. Conclusion Perfusion is reduced at the calcinotic sites, as measured by laser speckle imaging and also (although not significantly) as measured indirectly by thermography. That perfusion was decreased in the area of the calcinosis versus the adjacent skin may be due to the pressure on the skin leading to ischaemia, or it may be that calcinosis develops in areas which are under-perfused. This study has demonstrated the feasibility of imaging calcinosis properties. The ability to measure the depth and subcutaneous area with high frequency ultrasound may provide a useful outcome measure of treatment efficacy. Disclosures T.L. Moore None. E. Marjanovic None. J.B. Manning None. G. Dinsdale None. S. Wilkinson None. M.R. Dickinson None. A.L. Herrick None. A.K. Murray None.

scholarly journals High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Chen ◽  
Jiun-Yu Chen ◽  
Yu-Tang Tung ◽  
Hsiao-Ling Chen ◽  
Chia-Wen Kuo ◽  
...  
Keyword(s):  
Animal Models ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
High Frequency ◽  
Small Animal ◽  
Therapeutic Effects ◽  
High Frequency Ultrasound ◽  
Fibrosis Progression ◽  
Small Animal Models ◽  
Frequency Ultrasound

The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models. However, few studies have used high-frequency ultrasound (HFU, 40 MHz) to monitor changes in the rat liver and other hollow organs longitudinally. In this study, liver fibrosis was induced by administering dimethylnitrosamine (DMN) in SD rats, aged 8 weeks, for three consecutive days per week for up to 4 weeks. A Chinese herbal medicine Yi Guan Jian (YGJ) was orally administered (1.8 g/kg daily) to DMN-induced liver fibrosis rats for 2 weeks. Compared with the normal control rats, rats treated with DMN for either 2 weeks or 4 weeks had significantly lower body weights, liver indexes and elevation of hydroxyproline, GOT, and GPT contents. YGJ herbal treatment remarkably prevented rats from DMN-induced liver fibrosis. The HFU scoring results among the normal controls, 2-week DMN-treated rats, 4-week DMN-treated rats, and combined 2-week YGJ therapy with 4-week DMN-treated rats also reached statistical significance. Thus, HFU is an accurate tool for the longitudinal analysis of liver fibrosis progression in small-animal models, and the YGJ may be useful in reversing the development of hepatic fibrosis.

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