Design of a novel closed-loop deep brain stimulation system for Parkinson's disease and obsessive-compulsive disorder

Author(s):  
S D Karamintziou ◽  
B Piallat ◽  
S Chabardes ◽  
M Polosan ◽  
O David ◽  
...  
2019 ◽  
Vol 21 (3) ◽  
pp. 93-99
Author(s):  
Z. A. Zalyalova

Deep brain stimulation (DBS) involves implantation of electrodes in the basal ganglia of the brain. Dysregulation of neuronal activity in these structures is the cause of motor disorders. DBS is used in many motor (Parkinson’s disease, essential tremor, dystonia, ticks, tardive dyskinesia and others), psychological, behavioral and affective (depression, obsessive-compulsive disorder, epilepsy and others) disorders, as well as in severe pain syndromes resistant to drug therapy. However, the mechanisms of action of DBS are not fully understood. Currently, different theories and hypotheses are considered which explain its mechanism of treatment: rate model, “jamming” theory, hypotheses about the effect on neurogenesis, astrocyte activity, increased brain circulation, electrotaxis, etc.


Brain ◽  
2020 ◽  
Vol 143 (5) ◽  
pp. 1293-1296
Author(s):  
Jens Kuhn ◽  
Juan Carlos Baldermann

This scientific commentary refers to ‘Deep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder’, by Fridgeirsson etal. (doi:10.1093/brain/awaa100).


2013 ◽  
Vol 73 (9) ◽  
pp. e29-e31 ◽  
Author(s):  
Nicole C.R. McLaughlin ◽  
Elizabeth R. Didie ◽  
Andre G. Machado ◽  
Suzanne N. Haber ◽  
Emad N. Eskandar ◽  
...  

Author(s):  
Juan Carlos Baldermann ◽  
Thomas Schüller ◽  
Sina Kohl ◽  
Valerie Voon ◽  
Ningfei Li ◽  
...  

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