Tactile-Based Whole-Body Compliance With Force Propagation for Mobile Manipulators

Whole body asteroid fossils are rare in the geologic record and previously unreported from the Cenozoic of Florida. However, specimens of the extant species,Heliaster microbrachiusXantus, were recently discovered in upper Pliocene deposits. This marks the first reported fossil occurrence of the monogeneric Heliasteridae, a group today confined to the eastern Pacific. This discovery provides further non-molluscan evidence of the close similarities between the Neogene marine fauna of Florida and the modern fauna of the eastern Pacific. The extinction of the heliasters in the western Atlantic is consistent with the pattern of many other marine groups in the region which suffered impoverishment following uplift of the Central American isthmus.

Download Full-text

Cerebral Tissue Response in Chronic Electrode Implantation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080547 ◽

1977 ◽

Vol 35 ◽

pp. 624-625

Author(s):

R.F. Dodson ◽

L.W-F Chu ◽

N. Ishihara

Keyword(s):

Tissue Response ◽

Whole Body ◽

Platinum Electrodes ◽

Fixed Tissue ◽

Electrode Implantation ◽

Surface Areas ◽

Tissue Changes ◽

Micron Diameter ◽

Extent Of Damage ◽

Electrode Sheath

The extent of damage surrounding an implanted electrode in the cerebral cortex is a question of significant importance with regard to attaining consistency and validity of physiological recordings. In order to determine the extent of such tissue changes, 150 micron diameter platinum electrodes were implanted in the cortex of four adult baboons, and after eight days the animals were sacrificed by whole body perfusion with a 3% glutaraldehyde in 0.1M phosphate fixative.The calvarium was carefully removed and the electrode tracts were readily discernible in the firm, glutaraldehyde fixed tissue.Careful dissection of the zone of the electrode tract resulted in a small block which was further sectioned into tip, mid-tract and surface areas. Ultrastructurally, damage extended from the electrode sheath to the greatest extent of from 0.2 to 3.5 mm.

Download Full-text

Neutrophil Myeloperoxidase Destruction by Ultraviolet Irradiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100102778 ◽

1988 ◽

Vol 46 ◽

pp. 138-139

Author(s):

J. Hanker ◽

B. Giammara ◽

G. Strauss

Keyword(s):

Uv Radiation ◽

Myeloid Leukemia ◽

Stratospheric Ozone ◽

Psoriasis Patient ◽

Whole Body ◽

Human Neutrophils ◽

Cupric Nitrate ◽

The Earth ◽

Routine Handling ◽

Uvb Phototherapy

Only a fraction of the UV radiation emitted by the sun reaches the earth; most of the UVB (290-320nm) is eliminated by stratospheric ozone. There is increasing concern, however, that man-made chemicals are damaging this ozone layer. Although the effects of UV on DNA or as a carcinogen are widely known, preleukemia and acute myeloid leukemia (AML) have only rarely been reported in psoriasis patients treated with 8-methoxypsoralen and UV (PUVA). It was therefore of interest to study the effects of UV on the myeloperoxidase (MP) activity of human neutrophils. The peroxidase activity of enriched leukocyte preparations on coverslips was shown cytochemically with a diaminobenzidine medium and cupric nitrate intensification.Control samples (Figs. 1,4,5) of human bloods that were not specifically exposed to UV radiation or light except during routine handling were compared with samples which had been exposed in one of several different ways. One preparation (Fig. 2) was from a psoriasis patient who had received whole-body UVB phototherapy repeatedly.

Download Full-text

Adipokines as key players in β cell function and failure

Clinical Science ◽

10.1042/cs20190523 ◽

2019 ◽

Vol 133 (22) ◽

pp. 2317-2327 ◽

Cited By ~ 3

Author(s):

Nicolás Gómez-Banoy ◽

James C. Lo

Keyword(s):

Metabolic Diseases ◽

Cell Function ◽

Whole Body ◽

Pancreatic Β Cell ◽

Β Cell ◽

Cell Axis ◽

Β Cell Function ◽

Prevalence Of Obesity ◽

Specific Factors ◽

Whole Body Metabolism

Abstract The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. The pancreatic β cell, a key regulator of glucose metabolism due to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the “classic” adipokines will be discussed, followed by novel secreted adipocyte-specific factors that show therapeutic promise in regulating the adipose–pancreatic β cell axis.

Download Full-text