A Low Cost Arterial Simulator in Relation to Blood Clot Removal in the Human Vascular System

2010 ◽  
Author(s):  
M. Rai ◽  
G. Pearce ◽  
N.D. Perkinson ◽  
P. Brookfield ◽  
J. Asquith ◽  
...  
Keyword(s):  
Vascular System ◽  
Blood Clot ◽  
Low Cost ◽  
Clot Removal

scholarly journals Feasibility of Crosslinked Acrylic Shape Memory Polymer for a Thrombectomy Device

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Andrea D. Muschenborn ◽  
Keith Hearon ◽  
Brent L. Volk ◽  
Jordan W. Conway ◽  
Duncan J. Maitland
Keyword(s):  
Crosslink Density ◽  
Blood Clot ◽  
Shape Memory Polymer ◽  
Thermomechanical Properties ◽  
Recovery Stress ◽  
Element Analysis ◽  
Clot Removal ◽  
Acrylic Copolymers ◽  
Thrombectomy Device ◽  
And Performance

Purpose. To evaluate the feasibility of utilizing a system of SMP acrylates for a thrombectomy device by determining an optimal crosslink density that provides both adequate recovery stress for blood clot removal and sufficient strain capacity to enable catheter delivery. Methods. Four thermoset acrylic copolymers containing benzyl methacrylate (BzMA) and bisphenol A ethoxylate diacrylate (Mn∼512, BPA) were designed with differing thermomechanical properties. Finite element analysis (FEA) was performed to ensure that the materials were able to undergo the strains imposed by crimping, and fabricated devices were subjected to force-monitored crimping, constrained recovery, and bench-top thrombectomy. Results. Devices with 25 and 35 mole% BPA exhibited the highest recovery stress and the highest brittle response as they broke upon constrained recovery. On the contrary, the 15 mole% BPA devices endured all testing and their recovery stress (5 kPa) enabled successful bench-top thrombectomy in 2/3 times, compared to 0/3 for the devices with the lowest BPA content. Conclusion. While the 15 mole% BPA devices provided the best trade-off between device integrity and performance, other SMP systems that offer recovery stresses above 5 kPa without increasing brittleness to the point of causing device failure would be more suitable for this application.

scholarly journals Spontaneous Intracerebral Haematoma-II:Post-Operative Changes and Outcome of Burrhole Aspiration after Urokinase Mediated Clot Lysis

2017 ◽  
Vol 34 (2) ◽  
pp. 64-75
Author(s):  
Mohammad Nazrul Hossain ◽  
Shahryar Nabi ◽  
Sk Sader Hossain
Keyword(s):  
Diabetes Mellitus ◽  
Blood Clot ◽  
Clot Lysis ◽  
Intracerebral Hematoma ◽  
Invasive Technique ◽  
Intracerebral Haematoma ◽  
College Hospital ◽  
Clot Removal ◽  
Haematoma Volume ◽  
Number Of Patients

Background: Treatments of intracerebral hematoma (ICH) are controversial and surgical interventions in spontaneous ICH are required and more accepted. Although advantage of neurosurgical intervention conservative treatment of ICH has not been established, recent reports have suggested favourable effects of blood clot removal after liquefaction by means of urokinase.Objectives: To study the intervention by and out come in without or with complications of Burrhole aspiration treatment after urokinase mediated clot lysis; Study Design : Prospective interventional study. Place and Duration of Study: Departments of Neurosurgery and Radiology & Imaging ,Dhaka Medical College Hospital, Dhaka, Bangladesh from July 2010 to December 2010;Materials &Methods: A total of 30 Bangladeshi patients with spontaneous ICH (Age range: 40-75yrs,Mean age ±SD:59.1±11.52 years, Gender : 22 males, 8 females) full filling the criteria for spontaneous ICH were included in the study. The desired information relevant to the objectives were obtained and recorded carefully using a structured questionnaire; The Patients were treated with Burrhole aspiration after urokinase mediated lysis , evaluated for out come , complications and death and statistically analyzed ;Results: The results on delays of intervention ,types of intervention, doses of urokinase, post-operative changes in haematoma volume, outcome with Glasgow outcome scale(GOS) and GOS at follow–up, complications and death were presented with statistical analyses and significance .The outcome and death were compared with various variables such as hypertension (p <0.05), diabetes mellitus (p< 0.05) primary GOS (P<0.05),site of hematoma (p<0.05),volume of haematoma (p<0.05),ventricular extension of hematoma (p<0.05) and delay from ictus to intervention (p<0.05).Conclusion : It was observed that early treatment (within 24 hours of occurance) by using minimally invasive technique and clot removal by urokinase mediated lysis can improve the consequences especially those with haematoma volume < 40 ml, lobar haematoma and without ventricular extension. Bad prognostic factors were increase of blood pressure, diabetes mellitus, GOS level <8, haematoma in the basal ganglia , ventricular extension of the haematoma volume> 40 ml and delay in intervention. However, the present was conducted with 30 patients only and therefore, studies with larger number of patients are required to draw more meticulous and more definitive conclusions.J Bangladesh Coll Phys Surg 2016; 34(2): 64-75

In Vitro Design Investigation of a Rotating Helical Magnetic Swimmer for Combined 3-D Navigation and Blood Clot Removal

2020 ◽  
Vol 36 (3) ◽  
pp. 975-982
Author(s):  
Julien Leclerc ◽  
Haoran Zhao ◽  
Daniel Bao ◽  
Aaron T. Becker
Keyword(s):  
Blood Clot ◽  
Clot Removal

scholarly journals Progress towards Sustainable Control of Xylella fastidiosa subsp. pauca in Olive Groves of Salento (Apulia, Italy)

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 668
Author(s):  
Marco Scortichini ◽  
Stefania Loreti ◽  
Nicoletta Pucci ◽  
Valeria Scala ◽  
Giuseppe Tatulli ◽  
...  
Keyword(s):  
Control Strategy ◽  
Laser Scanning ◽  
Vascular System ◽  
Xylella Fastidiosa ◽  
Low Cost ◽  
Interdisciplinary Studies ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Olive Groves

Xylella fastidiosa subsp. pauca is the causal agent of “olive quick decline syndrome” in Salento (Apulia, Italy). On April 2015, we started interdisciplinary studies to provide a sustainable control strategy for this pathogen that threatens the multi-millennial olive agroecosystem of Salento. Confocal laser scanning microscopy and fluorescence quantification showed that a zinc-copper-citric acid biocomplex—Dentamet®—reached the olive xylem tissue either after the spraying of the canopy or injection into the trunk, demonstrating its effective systemicity. The biocomplex showed in vitro bactericidal activity towards all X. fastidiosa subspecies. A mid-term evaluation of the control strategy performed in some olive groves of Salento indicated that this biocomplex significantly reduced both the symptoms and X. f. subsp. pauca cell concentration within the leaves of the local cultivars Ogliarola salentina and Cellina di Nardò. The treated trees started again to yield. A 1H-NMR metabolomic approach revealed, upon the treatments, a consistent increase in malic acid and γ-aminobutyrate for Ogliarola salentina and Cellina di Nardò trees, respectively. A novel endotherapy technique allowed injection of Dentamet® at low pressure directly into the vascular system of the tree and is currently under study for the promotion of resprouting in severely attacked trees. There are currently more than 700 ha of olive groves in Salento where this strategy is being applied to control X. f. subsp. pauca. These results collectively demonstrate an efficient, simple, low-cost, and environmentally sustainable strategy to control this pathogen in Salento.

scholarly journals THE EFFICACY OF NASOGASTRIC TUBE IN A LARGE BLOOD CLOT EVACUATION DURING CYSTOSCOPY

2016 ◽  
Vol 23 (2) ◽  
Author(s):  
Caesar Khairul Wallad ◽  
Jumadi Santoso ◽  
Kuncoro Adi
Keyword(s):  
Nasogastric Tube ◽  
Negative Pressure ◽  
Blood Clot ◽  
Clot Removal ◽  
Blood Clots ◽  
Tube Suction ◽  
Clot Evacuation

Objective: In this study we introduce using nasogatric tube as an alternative to procure a safe and efficient way to remove large troublesome blood clots during cystoscopy procedure. Material & methods: We prospectively perform blood clot evacuation using nasogastric tube suction (NGT) on 21 patients in Hasan Sadikin GeneralHospital Bandung,within 6 months period. A 24 fr sheath and 16 fr NGT connected to suction unit with a 300 mmhg negative pressure was set. A repetitive back and forth technique was set in motion during the procedure. Cystoscopy time and NGT suction time was documented. Results: All patients were successfully managed with this method without complication during the procedure. The average time for clot removal was 5 minutes 8 seconds with average cystoscopy time was 20 minutes 12 seconds and average estimated blood clots volume was 483 grams. Conclusion: Evacuation using NGT suction is effective, safe and an efficient way to remove a large bothersome clots.

scholarly journals Dynamic Model and Characteristic Analysis of Viscosity-Ultraelasticity for Bionic Vascular Network

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Yanli Chen ◽  
Xueqing Zhang ◽  
Zhiyue Sang ◽  
Yongbai Sha ◽  
Guiqiang Bai
Keyword(s):  
Industrial Development ◽  
Mechanical Characteristics ◽  
Simulation Analysis ◽  
Vascular System ◽  
Low Cost ◽  
Coupling Model ◽  
Pipeline System ◽  
Piping System ◽  
Characteristic Analysis ◽  
Coupling Characteristics

Due to the large volume of pipeline transportation, low cost, safety and the reliability, and automatic control, it is widely used in many fields of industrial development and human daily life. Most of the traditional hydraulic pipelines are steel pipes, and their structure is simple. High resistance and high consumption during transportation are not conducive to the sustainable development of society. However, the human vascular system is intricate and has excellent mechanical properties. Built on the review, research on the fluid-solid coupling characteristics of a single bionic pipeline and piping system was carried out. In order to simulate the mechanical characteristics of a fluid conveying pipeline, a fluid-structure coupling model of equation 14 of a single pipeline and the transfer matrix of the pipeline system were established. The mechanical characteristics of the pipeline are studied, and the formula is calculated. The simulation analysis shows that the axial force and flow resistance decrease first and then stabilize with the increase of frequency. Finally, the experimental verification and the results show that the method is both reasonable and effective, because the simulation curve and the experimental curve are consistent in trend.

scholarly journals Thrombolytic Agents: Nanocarriers in Targeted Release

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6776
Author(s):  
Minghua Shen ◽  
Yujiao Wang ◽  
Fan Hu ◽  
Linwen Lv ◽  
Kui Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Vascular System ◽  
Blood Clot ◽  
Delivery Systems ◽  
The Body ◽  
High Morbidity ◽  
Nano Drug Delivery ◽  
Underlying Pathology ◽  
Targeted Release

A thrombus, known as a blood clot, may form within the vascular system of the body and impede blood flow. Thrombosis is the most common underlying pathology of cardiovascular diseases, contributing to high morbidity and mortality. However, the main thrombolytic drugs (urokinase, streptokinase, etc.) have shortcomings, including a short half-life, serious side effects and a lack of targeting, that limit their clinical application. The use of nano-drug delivery systems is expected to address these problems and a variety of approaches, including biological and physical responsive systems, have been explored. In this report, recent advances in the development of targeted nano-drug delivery systems are thoroughly reviewed.

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