Notice of Removal: Validation of high frame rate echo-PIV with optical PIV in a realistic left ventricular phantom

2017 ◽  
Author(s):  
Jason Voorneveld ◽  
Aswin Muralidharan ◽  
Timothy Hope ◽  
Hendrik Vos ◽  
Pieter Kruizinga ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Frame Rate ◽  
High Frame Rate

scholarly journals Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High Frame Rate EchoPIV in Patients

2021 ◽  
pp. 1-1
Author(s):  
Jason Voorneveld ◽  
Lana B.H. Keijzer ◽  
Mihai Strachinaru ◽  
Daniel J. Bowen ◽  
Ferit O. Mutluer ◽  
...  
Keyword(s):  
Acoustic Pressure ◽  
Left Ventricular ◽  
Frame Rate ◽  
High Frame Rate

scholarly journals Speckle-Tracking Echocardiography With Novel High Frame-Rate Imaging

2021 ◽  
Author(s):  
Kana Fujikura ◽  
Mohammed Makkiya ◽  
Muhammad Farooq ◽  
Yun Xing ◽  
Wayne Humphrey ◽  
...  
Keyword(s):  
Temporal Resolution ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Myocardial Strain ◽  
Left Ventricular ◽  
Frame Rate ◽  
High Frame Rate ◽  
Echocardiographic Images ◽  
The Impact ◽  
Normal Lvef

Background: global longitudinal strain (GLS) measures myocardial deformation and is a sensitive modality for detecting subclinical myocardial dysfunction and predicting cardiac outcomes. The accuracy of speckle-tracking echocardiography (STE) is dependent on temporal resolution. A novel software enables relatively high frame rate (Hi-FR) (~200 fps) echocardiographic images acquisition which empowers us to investigate the impact of Hi-FR imaging on GLS analysis. The goal of this pilot study was to demonstrate the feasibility of Hi-FR for STE. Methods: In this prospective study, we acquired echocardiographic images using clinical scanners on patients with normal left ventricular systolic function using Hi-FR and conventional frame rate (Reg-FR) (~50 FPS). GLS values were evaluated on apical 4-, 2- and 3-chamber images acquired in both Hi-FR and Reg-FR. Inter-observer and intra-observer variabilities were assessed in Hi-FR and Reg-FR. Results: There were 143 resting echocardiograms with normal LVEF included in this study. The frame rate of Hi-FR was 190 ± 25 and Reg-FR was 50 ± 3, and the heart rate was 71 ± 13. Strain values measured in Hi-FR were significantly higher than those measured in Reg-FR (all p < 0.001). Inter-observer and intra-observer correlations were strong in both Hi-FR and Reg-FR. Conclusions: We demonstrated that strain values were significantly higher using Hi-FR when compared with Reg-FR in patients with normal LVEF. It is plausible that higher temporal resolution enabled the measurement of myocardial strain at desired time point. The result of this study may inform clinical adoption of the novel technology. Further investigations are necessary to evaluate the value of Hi-FR to assess myocardial strain in stress echocardiography in the setting of tachycardia.

P1501Can we measure the stiffening of hypertensive hearts non-invasively? A shear wave imaging study using ultra-high frame rate echocardiography

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Cvijic ◽  
P Santos ◽  
A M Petrescu ◽  
S Bezy ◽  
M Orlowska ◽  
...  
Keyword(s):  
Left Atrium ◽  
Shear Wave ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Frame Rate ◽  
Volume Index ◽  
Healthy Controls ◽  
Myocardial Stiffness ◽  
High Frame Rate ◽  
Concentric Hypertrophy

Abstract Background Cardiac shear wave (SW) elastography is a novel technique based on high-frame-rate (HFR) echocardiography which has been shown to be related to myocardial stiffness. In this study we explore the relation between myocardial SW velocity and myocardial remodelling in remodelled hearts of patients with arterial hypertension (AH). Methods We prospectively included 33 treated AH patients with hypertrophic left ventricular (LV) remodelling (59±14 years, 55% male) and 26 aged matched healthy controls (55±15 years, 77% male). AH patients were further divided according to their LV geometric pattern into a concentric remodelling (CR) group (13 patients) and a concentric hypertrophy (CH) group (20 patients). LV parasternal long axis views were acquired with an experimental HFR ultrasound scanner (HD-PULSE) at 1266±317 frames per seconds. Myocardial acceleration maps were created from the HFR-datasets and an anatomical M-mode line was drawn along the midline of the interventricular septum (IVS). The propagation velocity of natural SWs occurring at mitral valve closure (MVC) was measured on these M-modes (Figure A) in order to assess passive myocardial stiffness. Standard echocardiography using a commercial scanner was performed to evaluate LV remodelling. Results SW velocities at MVC differed significantly between AH patients and controls (5.83±1.20 m/s vs. 4.04±0.96 m/s; p<0.001). Within the patient group, patients with CH had highest SW velocities at MVC (p<0.001), whereas values between controls and patients with CR were comparable (p=0.075) (Figure B). In AH patients, significant positive correlations were found between SW velocity at MVC and parameters of LV remodelling (IVS thickness: r=0.728, p<0.001; LV mass index: r=0.780, p<0.001, LV end-diastolic volume: r=0.604, p=0.008) (Figure C) and also parameters of diastolic function (E/e': r=0.495, p=0.005, left atrium diameter: r=0.866, p<0.001, left atrium volume index: r=0.661, p<0.001). Figure A, B, C Conclusions SW velocity – and therefore myocardial stiffness – is higher in AH patients compared to healthy controls and increases with increasing severity of hypertensive heart disease. Patients with concentric remodelling have still close-to-normal passive myocardial properties while patients with concentric hypertrophy show significant stiffening. Echocardiographic shear wave elastography is a promising new technique for the non-invasive assessment of myocardial stiffness and might provide valuable new insights into myocardial function and the pathophysiology of myocardial disease.

Shear wave elastography: can we estimate filing pressures?

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A.E Werner ◽  
S Bezy ◽  
M Orlowska ◽  
G Kubiak ◽  
W Desmet ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Shear Wave ◽  
Propagation Velocity ◽  
Shear Wave Elastography ◽  
Left Ventricular ◽  
Filling Pressure ◽  
Frame Rate ◽  
Funding Source ◽  
High Frame Rate ◽  
Non Invasive

Abstract Background The assessment of the left ventricular diastolic function is complex, as there is no single non-invasive parameter that provides a direct measurement of myocardial relaxation, myocardial compliance, or – as a surrogate - LV filling pressure. Estimation of diastolic function is therefore based on the combination of many parameters. Shear wave (SW) elastography (SWE) is a novel method based on high frame rate echocardiography. SWs occur after mechanical excitation of the myocardium, e.g. after mitral valve closure (MVC), and their propagation velocity is directly related to myocardial stiffness (MS). Purpose The aim of this study was to investigate if velocities of natural shear waves are related to MS at end diastole (ED) and, thus, could be used to estimate left ventricular end-diastolic pressures (LVEDP) as marker of diastolic function. Methods So far, we have prospectively enrolled 30 patients with a wide range of diastolic function, scheduled for heart catheterization so that LV filling pressures could be invasively measured. Patients with severe aortic stenosis, mitral stenosis of any degree and a more than moderate mitral regurgitation, as well as regional myocardial abnormalities or dysfunction in the anteroseptal wall were excluded. Echocardiography was performed immediately after catheterization. SW elastography in parasternal long axis views of the left ventricle (LV) was performed using an experimental scanner (HD-PULSE) at 1100±250 frames per second. Tissue acceleration maps were extracted from an anatomical M-mode line along the midline of the LV septum. The SW propagation velocity at MVC was measured as the slope on the M-mode acceleration map (Figure A). Results SW velocities at ED correlated very well with the invasively measured LVEDP (r=0.815, p&lt;0.001, Figure B). In comparison, classical echocardiographic parameters correlated only weakly or not with LVEDP (E/A: r=0.528, p=0.036, Figure C; E/e': r=−0.169, p=0,531, Figure D) with LVEDP. For the detection of an elevated LVEDP above 15 mmHg, a cut off value for the SW velocity at MVC of 3.75 m/s was associated with a Sensitivity of 92.9% and a Specificity of 83.3%. Conclusions End-diastolic shear wave velocities, measured by high frame rate shear wave elastography, showed a significant correlation with the end-diastolic filling pressure of the LV indicating a potential clinical value of the new method for a non-invasive and direct assessment of LV diastolic function. More patients will be included to confirm these findings. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Fonds Wetenschappelijk Onderzoek Flanderen (Research Foundation Flanders)

Abstract 13873: Quantitative Characteristics of Left Ventricular Vortex Flow in the Short and Long Axis Views by High Frame Rate Echocardiographic Particle Image Velocimetry

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Haruhiko Abe ◽  
Kasumi Masuda ◽  
Toshihiko Asanuma ◽  
Hikaru Koriyama ◽  
Yukihiro Koretsune ◽  
...  
Keyword(s):  
Particle Image Velocimetry ◽  
Vortex Flow ◽  
Cardiac Cycle ◽  
Particle Image ◽  
Left Ventricular ◽  
Frame Rate ◽  
Vortex Strength ◽  
High Frame Rate ◽  
Image Velocimetry ◽  
Quantitative Characteristics

Background: Vortex flow in the left ventricle (LV) has three-dimensional structure and plays an important role in avoiding excessive dissipation of energy. However, quantitative characteristics of long and short axis (LAX and SAX) vortex flow have not been elucidated. Echocardiographic particle image velocimetry (Echo-PIV) is an emerging technique to evaluate instantaneous vortical flow inside the LV. However, it has a limitation of underestimation of high velocities due to limited frame rate. Moreover, previous investigations have mainly focused on vortex from LAX view. Therefore, we used high frame rate Echo-PIV to quantitate vortex flow in SAX as well as in LAX views to understand characteristics of vortex three-dimensionally. Methods: Echocardiographic contrast images of the LV SAX and LAX were acquired from 8 open-chest healthy dogs. The acquisition frame rate was 135 frames per second and the contrast bubbles density was optimized for blood flow analysis. Echo-PIV analysis was performed off-line by using commercially available software and vorticity data were calculated in the region of interest (ROI) throughout the cardiac cycle. ROI was manually placed on the vortex. Vortex strength was defined as the averaged vorticity within the ROI. Results: In SAX, counterclockwise vortex was seen near the anterior wall, and in LAX clockwise vortex was seen in the anterior mid-ventricle. Both in SAX and LAX views, vortex strength showed significant phasic variations being largest in isovolumic contraction (vortex strength, SAX 9.2±2.3/s, p<0.001; LAX -12.0±2.4/s, p<0.001), and smallest in isovolumic relaxation (SAX -0.8±0.8/s, p<0.001; LAX -1.9±1.9/s, p<0.001). Conclusion: High frame rate Echo-PIV successfully demonstrated a complicated pattern of intracardiac vortex with phasic variation of its strength throughout a cardiac cycle in both SAX and LAX. This method may be a useful tool to assess physiological role of vortex in the flow dynamics.

Echocardiographic criteria for detection of postinfarction congestive heart failure in rats

2000 ◽  
Vol 89 (4) ◽  
pp. 1445-1454 ◽  
Author(s):  
Ivar Sjaastad ◽  
Ole M. Sejersted ◽  
Arnfinn Ilebekk ◽  
Reidar Bjørnerheim
Keyword(s):  
Heart Failure ◽  
Cluster Analysis ◽  
Congestive Heart Failure ◽  
Myocardial Function ◽  
Diastolic Pressure ◽  
Myocardial Dysfunction ◽  
Left Ventricular ◽  
Frame Rate ◽  
Shortening Velocity ◽  
High Frame Rate

We evaluated postinfarction myocardial function in rats and determined echocardiographic criteria for congestive heart failure (CHF) using high performance echocardiography. Extensive myocardial infarction (MI) was induced in rats by left coronary occlusion. Sham-operated animals served as controls. Five weeks later, high-frame rate (∼200 Hz), fully digitized, shallow-focus (10–25 mm), two-dimensional, M-mode and Doppler echocardiography was performed. A J-tree cluster analysis was performed using parameters indicative of CHF. Reproducibility was examined. The cluster analysis joined the animals into one Sham and two MI clusters. One of the MI clusters had clinical characteristics of CHF and elevated left ventricular end diastolic pressure. Among the echocardiographic variables, only posterior wall shortening velocity separated the failing and nonfailing MI clusters. We conclude that, by high frame rate echocardiography, it is possible to obtain high- quality recordings in rats. It is feasible to distinguish MI rats with CHF due to myocardial dysfunction from those without failure and to perform longitudinal studies on myocardial function.

scholarly journals The influence of hemodialysis-induced preload changes on the propagation speed of natural shear waves

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
S Bezy ◽  
M Orlowska ◽  
A Van Craenenbroeck ◽  
M Cvijic ◽  
J Duchenne ◽  
...  
Keyword(s):  
Wave Propagation ◽  
Shear Wave ◽  
Wave Speed ◽  
Shear Waves ◽  
Propagation Speed ◽  
Left Ventricular ◽  
Frame Rate ◽  
High Frame Rate ◽  
Shear Wave Speed ◽  
Wave Propagation Speed

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Research Foundation - Flanders (FWO) Background Shear wave elastography (SWE) is a novel ultrasound technique based on the detection of transverse waves travelling through the myocardium using high frame rate echocardiography. The propagation speed of these shear waves is dependent on the stiffness of the myocardium. Previous studies have shown the potential of SWE for the non-invasive assessment of myocardial stiffness. It is unclear, however, if preload changes lead to measurable changes in the shear wave propagation speed in the left ventricle. In patients undergoing hemodialysis, the volume status is acutely changed. In this way, the effect of preload changes on shear wave speed can be assessed. Purpose The aim of this study was to explore the influence of preload changes on end-diastolic shear wave propagation speed. Methods Until now, 6 patients (age: 80[53-85] years; female: n = 2) receiving hemodialysis treatment were included. Echocardiographic images were taken before and every hour during a 4 hour hemodialysis session. Left ventricular parasternal long-axis views were acquired with an experimental high frame rate ultrasound scanner (average frame rate: 1016[941-1310] Hz). Standard echocardiography was performed with a conventional ultrasound machine. Shear waves were visualized on tissue acceleration maps by drawing an M-mode line along the interventricular septum. Shear wave propagation speed after mitral valve closure (MVC) was calculated by measuring the slope of the wave pattern on the acceleration maps (Figure A). Results Over the course of hemodialysis, the systolic (141[135-156] mmHg vs. 165[105-176] mmHg; p = 0.35 among groups) and diastolic blood pressure (70[66-75] mmHg vs. 82[63-84] mmHg; p = 0.21 among groups), heart rate (56[54-73] bmp vs. 57[50-67] bpm; p = 0.76 among groups), E/A ratio (1.6[0.7-1.8] vs. 1.2[0.6-1.4]; p = 0.43 among groups) and E/e’ (14[9-15] vs. 9[8-13]; p = 0.24 among groups ) remained the same. The ultra-filtrated volumes are shown in Figure B. The shear wave propagation speed after MVC gradually decreased during hemodialysis (6.7[5.4-9.7] m/s vs. 4.4[3.6-9.0] m/s; p = 0.04 among groups) (Figure C). There was a moderate negative correlation between shear wave speed and the ultra-filtrated volume (r=-0.63; p &lt; 0.01) (Figure D). Conclusion The shear wave propagation speed at MVC significantly decreased over the course of hemodialysis and correlated to the ultra-filtrated volume. These results indicate that alterations in left ventricular preload affect the speed of shear waves at end-diastole. End-diastolic shear wave speed might therefore be a potential novel parameter for the evaluation of the left ventricular filling state. More patients will be included in the future to further explore these findings. Abstract Figure.

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