With decrease in amount of carbon fuels and aims of creating a cleaner environment, researches on hybrid electric vehicle technology have increased in years. The purpose of this study is to observe the change in fuel consumption of a simulated hybrid electric vehicle in different driving cycles. For this research, a series hybrid electric vehicle is modelled on MATLAB/Simulink. Subsequently, for simulating the tour of the vehicle, multiple driving cycles are modelled on the software and fed to vehicle model. For instance FTP-75, NEDC and UDDS are benefited and also a route from Turkey, the road from Istanbul to Ankara is modelled and simulated. Behavior of the vehicle on this route is also observed. After analyzing vehicle behavior in all these cycles, fuel consumption in each case is calculated and compared. As the result of this research, the most affordable cycle for this vehicle model is selected and possible ways of decreasing fuel consumption in other driving cycles is discussed.