Varicella zoster virus reactivation after coronavirus disease 2019 vaccination in Japanese patients: A series of 14 cases

2021 ◽  
Author(s):  
Yoshiaki Ibuchi ◽  
Fumiko Tamayose ◽  
Hiroki Katayama ◽  
Hidehisa Saeki ◽  
Shin‐Ichi Osada
Keyword(s):  
Varicella Zoster Virus ◽  
Japanese Patients ◽  
Virus Reactivation ◽  
Varicella Zoster

scholarly journals Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia

2013 ◽  
Vol 88 (5) ◽  
pp. 2704-2716 ◽  
Author(s):  
M. Steain ◽  
J. P. Sutherland ◽  
M. Rodriguez ◽  
A. L. Cunningham ◽  
B. Slobedman ◽  
...  
Keyword(s):  
T Cell ◽  
Varicella Zoster Virus ◽  
T Cell Responses ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Cell Responses

scholarly journals A Case Report of Acute Severe Myelitis and Meningitis Secondary to Varicella Zoster Virus Reactivation in a Patient with Acquired Immunodeficiency Syndrome

2021 ◽  
Author(s):  
Victor A Novelo-Hernández ◽  
Marco Cárdenas ◽  
Claudia Torres-González ◽  
Patricio Garcia-Espinosa ◽  
Rómulo Ramirez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Varicella Zoster Virus ◽  
Acquired Immunodeficiency Syndrome ◽  
Clinical Manifestations ◽  
Virus Reactivation ◽  
Neck Stiffness ◽  
Varicella Zoster ◽  
Wide Range ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Background: Myelitis post Herpes-Zoster is a rare condition that is typically associated with immunocompromised states. It usually starts as an acute loss of sensory and motor functions below the affected spinal cord level. The condition can range in severity from a mild to a fatal presentation. Other neurological complications include meningitis, atypical presentations should encourage the search for undiagnosed immunosuppression states. The Case: We describe the case of a 42-year-old man, previously undiagnosed with HIV, who developed acute myelitis and meningitis after the appearance of the classic zoster lesions. On lumbar puncture and subsequent CSF analysis, the patient was found to have Froin’s Syndrome. The patient was initiated with ceftriaxone, vancomycin, and acyclovir regimen and prophylactic antiphymic treatment was also added. After 14 days in the hospital, the fever, headache, and neck stiffness subsided while the sphincter function and lower limb paraplegia did not improve.   Conclusion: Varicella zoster virus reactivation suggests underlying immunosuppression. This case demonstrates the importance of being cognizant to the wide range of clinical manifestations that may suggest spinal cord involvement after clinical reactivation. Furthermore, physicians also need to be mindful that Acquired Immunodeficiency Syndrome (AIDS) and other immunodeficiency states could present with atypical clinical manifestations.

scholarly journals Pharyngeal dysphagia due to Varicella zoster virus meningoradiculitis and full recovery: Case report and endoscopic findings

2018 ◽  
Vol 6 ◽  
pp. 2050313X1875656
Author(s):  
Paul Muhle ◽  
Sonja Suntrup-Krueger ◽  
Rainer Dziewas ◽  
Tobias Warnecke
Keyword(s):  
Varicella Zoster Virus ◽  
Brain Magnetic Resonance Imaging ◽  
Virus Reactivation ◽  
Swallowing Function ◽  
Percutaneous Gastrostomy ◽  
Negative Finding ◽  
Varicella Zoster ◽  
Fluid Analysis ◽  
Pharyngeal Dysphagia ◽  
Acyclovir Treatment

Varicella zoster virus reactivation is a rare cause of pharyngeal dysphagia with long-term sequelae persisting in most cases. A 76-year-old immunocompetent woman presented with a 4-week history of dysphagia and dysphonia. Brain magnetic resonance imaging displayed a negative finding. Fiberoptic endoscopic evaluation of swallowing showed a severe dysphagia leading to a percutaneous gastrostomy eventually. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis and polymerase chain reaction amplified Varicella zoster virus DNA. Eight months after Acyclovir treatment and despite a persisting impairment of the recurrent laryngeal nerve, regular swallowing function was regained and percutaneous gastrostomy could be removed.

scholarly journals Infection of the central nervous system caused by varicella zoster virus reactivation: a retrospective case series study

2013 ◽  
Vol 17 (7) ◽  
pp. e529-e534 ◽  
Author(s):  
Juan Carlos Lozano Becerra ◽  
Robert Sieber ◽  
Gladys Martinetti ◽  
Silvia Tschuor Costa ◽  
Pascal Meylan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Varicella Zoster Virus ◽  
Case Series ◽  
Virus Reactivation ◽  
Retrospective Case ◽  
Varicella Zoster ◽  
Case Series Study ◽  
The Central Nervous System ◽  
Series Study

scholarly journals Herpes Zoster Infection Presenting as Aseptic Meningitis and Dermatomal Rash in Immunocompetent Adult

2020 ◽  
Vol 2020 ◽  
pp. 1-3 ◽  
Author(s):  
Suyash Dawadi ◽  
Sudesh Lamsal ◽  
Bhupendra Shah
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Aseptic Meningitis ◽  
Elderly Population ◽  
Virus Reactivation ◽  
Herpes Zoster Infection ◽  
Immunocompetent Adult ◽  
Varicella Zoster ◽  
Vesicular Rash ◽  
Immunocompromised Status

Herpes zoster is a localized, painful, and vesicular rash involving one or adjacent dermatomes caused by varicella-zoster virus reactivation. Herpes zoster presenting as aseptic meningitis is prevalent among elderly population and people with immunocompromised status. However, it is a rare phenomenon in the young immunocompetent adult; hence, we are reporting a case of a herpes zoster infection presenting as aseptic meningitis and dermatological manifestation in a 19-year-old immunocompetent male.

scholarly journals Varicella Vaccine Meningitis as a Complication of Herpes Zoster in Twice-Immunized Immunocompetent Adolescents

2020 ◽  
Vol 35 (13) ◽  
pp. 889-895 ◽  
Author(s):  
Veena Ramachandran ◽  
Stephen C. Elliott ◽  
Kathie L. Rogers ◽  
Randall J. Cohrs ◽  
Miles Weinberger ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Varicella Vaccine ◽  
The United States ◽  
Vaccine Virus ◽  
Virus Reactivation ◽  
Wild Type ◽  
Varicella Zoster ◽  
Intravenous Acyclovir

Varicella-zoster virus vaccination is recommended for virtually all young children in the United States, Canada, and several other countries. Varicella vaccine is a live attenuated virus that retains some of its neurotropic properties. Herpes zoster caused by vaccine virus still occurs in immunized children, although the rate is much lower than in children who had wild-type varicella. It was commonly thought that 2 varicella vaccinations would protect children against the most serious complication of meningitis following herpes zoster; however, 2 meningitis cases have already been published. We now report a third case of varicella vaccine meningitis and define risk factors shared by all 3 immunized adolescents. The diagnosis in cerebrospinal fluid in this third case was verified by amplifying and sequencing portions of the viral genome, to document fixed alleles found only in the vaccine strain. Viral antibody was also detected in the cerebrospinal fluid by confocal microscopy. When compared with the other 2 cases, remarkably all 3 were 14 years old when meningitis occurred. All 3 were treated with intravenous acyclovir, with complete recovery. The adolescent in our case report also had recurrent asthma, which was treated with both prednisone tablets and beclomethasone inhaler before onset of meningitis. When the 3 cases were considered together, they suggested that immunity to varicella-zoster virus may be waning sufficiently in some twice-immunized adolescents to make them vulnerable to varicella vaccine virus reactivation and subsequent meningitis. This complication rarely happens in children after wild-type varicella.

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