Epidermal Differentiation Enhances CRABP II Expression in Human Skin

1994 ◽  
Vol 103 (6) ◽  
pp. 785-790 ◽  
Author(s):  
Mark S Eller ◽  
Daniel D Harkness ◽  
J.a.g. Bhawan ◽  
Barbara A Gilchrest
Keyword(s):  
Human Skin ◽  
Epidermal Differentiation ◽  
Crabp Ii

Improvement of epidermal differentiation and barrier function in reconstructed human skin after grafting onto athymic nude mice

1994 ◽  
Vol 286 (2) ◽  
pp. 107-114 ◽  
Author(s):  
I. Higounenc ◽  
M. D�marchez ◽  
M. R�gnier ◽  
R. Schmidt ◽  
M. Ponec ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Barrier Function ◽  
Epidermal Differentiation ◽  
Athymic Nude Mice ◽  
Reconstructed Human Skin ◽  
Grafting Onto

Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases

1996 ◽  
Vol 288 (8) ◽  
pp. 426-430 ◽  
Author(s):  
B. Algermissen ◽  
Jörg Sitzmann ◽  
P. LeMotte ◽  
Beate Czarnetzki
Keyword(s):  
Differential Expression ◽  
Human Skin ◽  
Skin Diseases ◽  
Crabp Ii

scholarly journals Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes

2018 ◽  
Vol 66 (11) ◽  
pp. 813-824 ◽  
Author(s):  
Carolyne Simard-Bisson ◽  
Lorraine Andrée Parent ◽  
Véronique J. Moulin ◽  
Bernard Fruteau de Laclos
Keyword(s):  
Human Skin ◽  
Expression Profiles ◽  
Skin Barrier ◽  
Epidermal Differentiation ◽  
Skin Barrier Function ◽  
Skin Substitutes ◽  
Differentiation Markers ◽  
Normal Human Skin ◽  
Normal Human ◽  
Engineered Skin Substitutes

Lipoxygenases (LOXs) are enzymes likely to be involved in corneocyte lipid envelope formation and skin barrier function. In humans, mutations in epidermis-type lipoxygenase 3 ( eLOX-3) and 12R–lipoxygenase ( 12R-LOX) genes are associated with autosomal recessive congenital ichthyosis (ARCI), whereas deletion of these genes in mice causes epidermal defects. LOXs also represent a matter of interest in psoriasis as well as in cancer research. However, their expression as well as the exact role of these enzymes in normal human skin have not been fully described. Our goal was to characterize the expression of epidermal LOXs in both normal human skin and Tissue-Engineered Skin Substitutes (TESS) and to consider TESS as a potential model for LOX functional studies. Staining for epidermal differentiation markers and LOXs was performed, in parallel, on normal human skin and TESS. Our results showed similar expression profiles in TESS when compared with native skin for e-LOX3, 12R-LOX, 12S-lipoxygenase (12S-LOX), and 15-lipoxygenase 2 (15-LOX-2) but not for 15-lipoxygenase 1 (15-LOX-1). Because of their appropriate epidermal differentiation and LOX expression, TESS represent an alternative model for future studies on LOX function.

Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice

2004 ◽  
Vol 150 (4) ◽  
pp. 658-667 ◽  
Author(s):  
S. Del Bino ◽  
C. Vioux ◽  
P. Rossio-Pasquier ◽  
A. Jomard ◽  
M. Demarchez ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Ultraviolet B ◽  
Epidermal Differentiation ◽  
Normal Human Skin ◽  
Normal Human

scholarly journals TNF-α and Th2 Cytokines Induce Atopic Dermatitis–Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents

2014 ◽  
Vol 134 (7) ◽  
pp. 1941-1950 ◽  
Author(s):  
Mogbekeloluwa O. Danso ◽  
Vincent van Drongelen ◽  
Aat Mulder ◽  
Jeltje van Esch ◽  
Hannah Scott ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Human Skin ◽  
Epidermal Differentiation ◽  
Th2 Cytokines ◽  
Skin Equivalents ◽  
Tnf Α ◽  
Stratum Corneum Lipids

scholarly journals Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis

2016 ◽  
Vol 136 (6) ◽  
pp. 1255-1266 ◽  
Author(s):  
Daniela Passeri ◽  
Elena Doldo ◽  
Chiara Tarquini ◽  
Gaetana Costanza ◽  
Donatella Mazzaglia ◽  
...  
Keyword(s):  
Human Skin ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Poorly Differentiated ◽  
Crabp Ii

Retinol elicits epidermal acanthosis and CRABP-II mRNA expression, but insignificant erythema when topically applied to human skin

1993 ◽  
Vol 6 (1) ◽  
pp. 42
Author(s):  
S Kang ◽  
CEM Griffiths ◽  
JT Elder ◽  
EA Duell ◽  
MA Cromie ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Human Skin ◽  
Crabp Ii

Stimulus-Selective Induction of CRABP-II mRNA: A Marker for Retinoic Acid Action in Human Skin

1993 ◽  
Vol 100 (4) ◽  
pp. 356-359 ◽  
Author(s):  
James T. Elder ◽  
Matthew A. Cromie ◽  
Christopher E.M. Griffiths ◽  
Pierre Chambon ◽  
John J. Voorhees
Keyword(s):  
Retinoic Acid ◽  
Human Skin ◽  
Crabp Ii
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