scholarly journals Tumor‐associated macrophages: An important player in breast cancer progression

2021 ◽  
Author(s):  
Xinqun Huang ◽  
Jingsong Cao ◽  
Xuyu Zu
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Tumor Associated Macrophages ◽  
Important Player

scholarly journals Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3526
Author(s):  
Yen-Yun Wang ◽  
Huan-Da Chen ◽  
Steven Lo ◽  
Yuk-Kwan Chen ◽  
Yu-Ci Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Conditioned Medium ◽  
Cancer Progression ◽  
Mononuclear Cells ◽  
Breast Cancer Progression ◽  
Migration And Invasion ◽  
Clinical Samples ◽  
Tumor Associated Macrophages ◽  
Peripheral Blood Mononuclear ◽  
Orthotopic Mouse Model

Visfatin, an adipocytokine highly expressed in breast tumor tissues, is associated with breast cancer progression. Recent studies showed that adipocytokines mediate tumor development through adipocytokine tumor-stromal interactions in the tumor microenvironment. This study focused on the interaction between one key stromal constituent—tumor-associated macrophages—and visfatin. Pretreatment of THP-1 and peripheral blood mononuclear cells (PBMCs) with recombinant visfatin resulted in M2-polarization determined by CD163 and CD206 expression. Indirect co-culture with visfatin-treated THP-1 (V-THP-1) promoted the viability, migration, tumorsphere formation, EMT, and stemness of breast cancer cells. Cytokine array identified an increased CXCL1 secretion in V-THP-1 conditioned medium and recombinant CXCL1 enhanced cell migration and invasion, which were abrogated by the CXCL1-neutralizing antibody. Additionally, visfatin induced pERK in THP-1 cells and clinical samples confirmed a positive CXCL1/pERK correlation. In an orthotopic mouse model, the tumor bioluminescent signal of luciferase-expressing MDA-MB-231 (Luc-MDA-MB-231) cells co-cultured with V-THP-1 and the expression of proliferation marker Ki67 were significantly higher than that co-cultured with THP-1. Furthermore, tail vein-injected Luc-MDA-MB-231 pretreated with V-PBMCs conditioned medium metastasized to lungs more frequently compared to control, and this was reversed by CXCL1 blocking antibody. In summary, this study demonstrated that visfatin enhanced breast cancer progression via pERK/CXCL1 induction in macrophages.

scholarly journals The role of tumor-associated macrophages in breast cancer progression

2013 ◽  
Vol 43 (1) ◽  
pp. 5-12 ◽  
Author(s):  
ELIAS OBEID ◽  
RITA NANDA ◽  
YANG-XIN FU ◽  
OLUFUNMILAYO I. OLOPADE
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Tumor Associated Macrophages

Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression

2020 ◽  
Vol 178 ◽  
pp. 114113
Author(s):  
Lei Wang ◽  
Ying-Shuang Li ◽  
Lu-Gang Yu ◽  
Xin-Ke Zhang ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Tumor Associated Macrophages ◽  
Galectin 3

Beta haemoglobin (hbb) is a novel marker of breast cancer progression

2014 ◽  
Author(s):  
Mattia Capulli ◽  
Adriano Angelucci ◽  
Anna Teti ◽  
Patrizia Sanita ◽  
Luca Ventura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression
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