scholarly journals Evaluating the impact of pyrethroid insecticide resistance on reproductive fitness in Sitobion avenae

2021 ◽  
Author(s):  
Lael E. Walsh ◽  
Olaf Schmidt ◽  
Stephen P. Foster ◽  
Coline Varis ◽  
Jim Grant ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Reproductive Fitness ◽  
Sitobion Avenae ◽  
Pyrethroid Insecticide ◽  
The Impact

scholarly journals A Semantic Framework to Improve Interoperability of Malaria Surveillance Systems

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Jon Hael Simon Brenas ◽  
Mohammad S. Al-Manir ◽  
Kate Zinszer ◽  
Christopher J. Baker ◽  
Arash Shaban-Nejad
Keyword(s):  
Semantic Web ◽  
Insecticide Resistance ◽  
Data Access ◽  
Data Sources ◽  
Surveillance Systems ◽  
Malaria Surveillance ◽  
Semantic Framework ◽  
Ontology Language ◽  
The Impact ◽  
Target Data

ObjectiveMalaria is one of the top causes of death in Africa and some other regions in the world. Data driven surveillance activities are essential for enabling the timely interventions to alleviate the impact of the disease and eventually eliminate malaria. Improving the interoperability of data sources through the use of shared semantics is a key consideration when designing surveillance systems, which must be robust in the face of dynamic changes to one or more components of a distributed infrastructure. Here we introduce a semantic framework to improve interoperability of malaria surveillance systems (SIEMA).IntroductionIn 2015, there were 212 million new cases of malaria, and about 429,000 malaria death, worldwide. African countries accounted for almost 90% of global cases of malaria and 92% of malaria deaths. Currently, malaria data are scattered across different countries, laboratories, and organizations in different heterogeneous data formats and repositories. The diversity of access methodologies makes it difficult to retrieve relevant data in a timely manner. Moreover, lack of rich metadata limits the reusability of data and its integration. The current process of discovering, accessing and reusing the data is inefficient and error-prone profoundly hindering surveillance efforts.As our knowledge about malaria and appropriate preventive measures becomes more comprehensive malaria data management systems, data collection standards, and data stewardship are certain to change regularly. Collectively these changes will make it more difficult to perform accurate data analytics or achieve reliable estimates of important metrics, such as infection rates. Consequently, there is a critical need to rapidly re-assess the integrity of data and knowledge infrastructures that experts depend on to support their surveillance tasks.MethodsIn order to address the challenge of heterogeneity of malaria data sources we recruit domain specific ontologies in the field (e.g. IDOMAL (1)) that define a shared lexicon of concepts and relations. These ontologies are expressed in the standard Web Ontology Language (OWL).To over come challenges in accessing distributed data resources we have adopted the Semantic Automatic Discovery & Integration framework (SADI) (2) to ensure interoperability. SADI provides a way to describe services that provide access to data, detailing inputs and outputs of services and a functional description. Existing ontology terms are used when building SADI Service descriptions. The services can be discovered by querying a registry and combined into complex workflows. Users can issue SPARQL syntax to a query engine which can plan complex workflows to fetch actual data, without having to know how target data is structured or where it is located.In order to tackle changes in target data sources, the ontologies or the service definitions, we create a Dashboard (3) that can report any changes. The Dashboard reuses some existing tools to perform a series of checks. These tools compare versions of ontologies and databases allowing the Dashboard to report these changes. Once a change has been identified, as series of recommendations can be made, e.g. services can be retired or updated so that data access can continue.ResultsWe used the Mosquito Insecticide Resistance Ontology (MIRO) (5) to define the common lexicon for our data sources and queries. The sources we created are CSV files that use the IRbase (4) schema. With the data defined using we specified several SPARQL queries and the SADI services needed to answer them. These services were designed to enabled access to the data separated in different files using different formats. In order to showcase the capabilities of our Dashboard, we also modified parts of the service definitions, of the ontology and of the data sources. This allowed us to test our change detection capabilities. Once changes where detected, we manually updated the services to comply with a revised ontology and data sources and checked that the changes we proposed where yielding services that gave the right answers. In the future, we plan to make the updating of the services automatic.ConclusionsBeing able to make the relevant information accessible to a surveillance expert in a seamless way is critical in tackling and ultimately curing malaria. In order to achieve this, we used existing ontologies and semantic web services to increase the interoperability of the various sources. The data as well as the ontologies being likely to change frequently, we also designed a tool allowing us to detect and identify the changes and to update the services so that the whole surveillance systems becomes more resilient.References1. P. Topalis, E. Mitraka, V Dritsou, E. Dialynas and C. Louis, “IDOMAL: the malaria ontology revisited” in Journal of Biomedical Semantics, vol. 4, no. 1, p. 16, Sep 2013.2. M. D. Wilkinson, B. Vandervalk and L. McCarthy, “The Semantic Automated Discovery and Integration (SADI) web service design-pattern, API and reference implementation” in Journal of Biomedical Semantics, vol. 2, no. 1, p. 8, 2011.3. J.H. Brenas, M.S. Al-Manir, C.J.O. Baker and A. Shaban-Nejad, “Change management dashboard for the SIEMA global surveillance infrastructure”, in International Semantic Web Conference, 20174. E. Dialynas, P. Topalis, J. Vontas and C. Louis, "MIRO and IRbase: IT Tools for the Epidemiological Monitoring of Insecticide Resistance in Mosquito Disease Vectors", in PLOS Neglected Tropical Diseases 2009

scholarly journals Impact of insecticide resistance in Anopheles arabiensis on malaria incidence and prevalence in Sudan and the costs of mitigation

2017 ◽  
Vol 114 (52) ◽  
pp. E11267-E11275 ◽  
Author(s):  
Hmooda Toto Kafy ◽  
Bashir Adam Ismail ◽  
Abraham Peter Mnzava ◽  
Jonathan Lines ◽  
Mogahid Shiekh Eldin Abdin ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Pyrethroid Resistance ◽  
Malaria Incidence ◽  
Disease Incidence ◽  
Indoor Residual Spraying ◽  
Sub Saharan Africa ◽  
Malaria Vectors ◽  
Incidence And Mortality ◽  
Additional Protection ◽  
The Impact

Insecticide-based interventions have contributed to ∼78% of the reduction in the malaria burden in sub-Saharan Africa since 2000. Insecticide resistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality. A major impediment to the implementation of insecticide resistance management strategies is that evidence of the impact of resistance on malaria disease burden is limited. A cluster randomized trial was conducted in Sudan with pyrethroid-resistant and carbamate-susceptible malaria vectors. Clusters were randomly allocated to receive either long-lasting insecticidal nets (LLINs) alone or LLINs in combination with indoor residual spraying (IRS) with a pyrethroid (deltamethrin) insecticide in the first year and a carbamate (bendiocarb) insecticide in the two subsequent years. Malaria incidence was monitored for 3 y through active case detection in cohorts of children aged 1 to <10 y. When deltamethrin was used for IRS, incidence rates in the LLIN + IRS arm and the LLIN-only arm were similar, with the IRS providing no additional protection [incidence rate ratio (IRR) = 1.0 (95% confidence interval [CI]: 0.36–3.0; P = 0.96)]. When bendiocarb was used for IRS, there was some evidence of additional protection [interaction IRR = 0.55 (95% CI: 0.40–0.76; P < 0.001)]. In conclusion, pyrethroid resistance may have had an impact on pyrethroid-based IRS. The study was not designed to assess whether resistance had an impact on LLINs. These data alone should not be used as the basis for any policy change in vector control interventions.

Application of the FAO-recommended method for detecting insecticide resistance in Aphis jabae Scopoli, Sitobion avenae (F.), Metopolophium dirhodum (Walker) and Rhopalosiphum padi (L.) (Hemiptera: Aphididae)

1983 ◽  
Vol 73 (1) ◽  
pp. 107-115 ◽  
Author(s):  
M. F. Stribley ◽  
G. D. MOORES ◽  
A. L. DEVONSHIRE ◽  
R. M. SAWICKI
Keyword(s):  
Insecticide Resistance ◽  
Rhopalosiphum Padi ◽  
Sitobion Avenae ◽  
Aphis Fabae ◽  
Cereal Aphids ◽  
Metopolophium Dirhodum ◽  
Large Numbers ◽  
The Uk ◽  
Dip Test

AbstractBaseline toxicity measurements established discriminating concentrations of pirimicarb and demeton-S-methyl guaranteed to kill susceptible examples of Aphis fabae Scop., Sitobion avenae (F.), Metopolophium dirhodum (Wlk.) and Rhopalosiphum padi (L.) in the dip-test, the FAO-recommended method for detecting resistance in aphids. There was no evidence for resistance to either insecticide in field-collected populations of aphids from various parts of the UK or amongst variants of S. avenae characterised by staining their esterases after electrophoresis. New, simple techniques for rearing large numbers of colonies of cereal aphids are described.

Evolution of Drosophila insecticide resistance

Genome ◽  
1993 ◽  
Vol 36 (1) ◽  
pp. 1-7 ◽  
Author(s):  
R. A. Morton
Keyword(s):  
Insecticide Resistance ◽  
Quantitative Traits ◽  
Molecular Genetic ◽  
Resistance Evolution ◽  
Target Molecules ◽  
Genetic Techniques ◽  
The Cost ◽  
The Impact ◽  
The Relationship ◽  
Selection Of

The impact of insecticide resistance is well documented. It includes the toxic effects of pesticides on the environment and the cost of the increased amounts of insecticides required to effectively control resistant insects. Resistance evolves by the selection of genes that confer tolerance to insecticides. Several resistance genes have been identified and cloned in Drosophila, including genes for mutant target molecules and genes that increase insecticide degradation. Drosophila is a useful system to understand the evolution of quantitative traits in general as well as the population genetics of insecticide resistance. Through it, we may hope to understand the relationship between discrete genetic change and continuously varying characters. In addition, molecular genetic techniques developed using Drosophila can eventually be transferred to other insects in order to help control pest populations.Key words: insecticide resistance, evolution of tolerance, selection of resistant genes, molecular genetics, Drosophila.

Insecticide resistance status and detoxification enzymes of wheat aphids Sitobion avenae and Rhopalosiphum padi

2017 ◽  
Vol 60 (8) ◽  
pp. 927-930 ◽  
Author(s):  
Liuping Zhang ◽  
Hong Lu ◽  
Kun Guo ◽  
Shumin Yao ◽  
Feng Cui
Keyword(s):  
Insecticide Resistance ◽  
Rhopalosiphum Padi ◽  
Sitobion Avenae ◽  
Detoxification Enzymes

scholarly journals Monitoring of Insecticide Resistance in Anopheles culicifacies in Twelve Districts of Madhya Pradesh, Central India (2017–2019)

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Ashok K. Mishra ◽  
Praveen K Bharti ◽  
Gyan Chand ◽  
Aparup Das ◽  
Himanshu Jayswar ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Vector Control ◽  
Indoor Residual Spraying ◽  
Central India ◽  
Control Programme ◽  
Madhya Pradesh ◽  
Control Measures ◽  
Malaria Vectors ◽  
Malaria Vector Control ◽  
The Impact

Background. Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are malaria vector control measures used in India, but the development of insecticide resistance poses major impediments for effective vector control strategies. As per the guidelines of the National Vector Borne Disease Control Programme (NVBDCP), the study was conducted in 12 districts of Madhya Pradesh to generate data on insecticide resistance in malaria vectors. Methods. The susceptibility tests were conducted on adult An. culicifacies as per the WHO standard technique with wild-caught mosquitoes. The blood-fed female mosquitoes were exposed in 3 to 4 replicates on each occasion to the impregnated papers with specified discriminating dosages of the insecticides (DDT: 4%, malathion: 5%, deltamethrin: 0.05%, and alphacypermethrin: 0.05%), for one hour, and mortality was recorded after 24-hour holding. Results. An. culicifacies was found resistant to DDT 4% in all the 12 districts and malathion in 11 districts. The resistance to alphacypermethrin was also observed in two districts, and possible resistance was found to alphacypermethrin in seven districts and to deltamethrin in eight districts, while the vector was found susceptible to both deltamethrin and alphacypermethrin in only 3 districts. Conclusion. An. culicifacies is resistant to DDT and malathion and has emerging resistance to pyrethroids, alphacypermethrin, and deltamethrin. Therefore, regular monitoring of insecticide susceptibility in malaria vectors is needed for implementing effective vector management strategies. However, studies to verify the impact of IRS with good coverage on the transmission of disease are required before deciding on the change of insecticide in conjunction with epidemiological data.

Nicotinoid and pyrethroid insecticide resistance in houseflies (Diptera: Muscidae) collected from Florida dairies

2009 ◽  
Vol 66 (3) ◽  
pp. 290-294 ◽  
Author(s):  
Phillip E Kaufman ◽  
Sonia C Nunez ◽  
Rajinder S Mann ◽  
Christopher J Geden ◽  
Michael E Scharf
Keyword(s):  
Insecticide Resistance ◽  
Pyrethroid Insecticide

scholarly journals Insecticide exposure impacts vector–parasite interactions in insecticide-resistant malaria vectors

2014 ◽  
Vol 281 (1786) ◽  
pp. 20140389 ◽  
Author(s):  
Haoues Alout ◽  
Innocent Djègbè ◽  
Fabrice Chandre ◽  
Luc Salako Djogbénou ◽  
Roch Kounbobr Dabiré ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Vector Competence ◽  
Resistance Mechanisms ◽  
Malaria Vectors ◽  
Anopheles Gambiae S.S ◽  
Strong Trend ◽  
Insecticide Exposure ◽  
The Impact ◽  
Selection Of ◽  
Selection Of Resistance

Currently, there is a strong trend towards increasing insecticide-based vector control coverage in malaria endemic countries. The ecological consequence of insecticide applications has been mainly studied regarding the selection of resistance mechanisms; however, little is known about their impact on vector competence in mosquitoes responsible for malaria transmission. As they have limited toxicity to mosquitoes owing to the selection of resistance mechanisms, insecticides may also interact with pathogens developing in mosquitoes. In this study, we explored the impact of insecticide exposure on Plasmodium falciparum development in insecticide-resistant colonies of Anopheles gambiae s.s. , homozygous for the ace-1 G119S mutation (Acerkis) or the kdr L1014F mutation (Kdrkis). Exposure to bendiocarb insecticide reduced the prevalence and intensity of P. falciparum oocysts developing in the infected midgut of the Acerkis strain, whereas exposure to dichlorodiphenyltrichloroethane reduced only the prevalence of P. falciparum infection in the Kdrkis strain. Thus, insecticide resistance leads to a selective pressure of insecticides on Plasmodium parasites, providing, to our knowledge, the first evidence of genotype by environment interactions on vector competence in a natural Anopheles–Plasmodium combination . Insecticide applications would affect the transmission of malaria in spite of resistance and would reduce to some degree the impact of insecticide resistance on malaria control interventions.

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