scholarly journals A multimethod computational simulation approach for investigating mitochondrial dynamics and dysfunction in degenerative aging

Aging Cell ◽  
2017 ◽  
Vol 16 (6) ◽  
pp. 1244-1255 ◽  
Author(s):  
Timothy E. Hoffman ◽  
Katherine J. Barnett ◽  
Lyle Wallis ◽  
William H. Hanneman
Author(s):  
Tung Xuan Vuong ◽  
Willow Yangliu Li ◽  
Ahmed Al-Jumaily ◽  
Neel Pandey

Abstract The paper presents an investigation into the noise generated by structural vibration of an electric motor used in appliance products using Computational Simulation Approach. In particular, a 3-D numerical simulation model is specifically developed to predict the frequency response of the stator under three different simulation conditions: radial force only, tangential force only and the combination of both forces. The obtained data is used to analyze the acoustic generation in the far-field. Experimental is used to validate the predicted results. It shows the predicted results are very close to experimental results.


Chemosphere ◽  
2021 ◽  
Vol 262 ◽  
pp. 127680
Author(s):  
Mohammad Abbasi ◽  
Javad Aminian-Dehkordi ◽  
Seyyed Mohammad Mousavi

1993 ◽  
Vol 42 (5) ◽  
pp. 762
Author(s):  
ZHANG SHI-CHANG ◽  
WANG WEN-YAO ◽  
XU YONG

Lubricants ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 8 ◽  
Author(s):  
Michael Pusterhofer ◽  
Florian Summer ◽  
Michael Maier ◽  
Florian Grün

Optimizing the surface topography of cast iron crankshafts offers the opportunity to use this material as an alternative to steel in high-performance combustion engines. In the past, this was not possible due to the higher wear on bearing shells and the higher friction losses in relation to forged steel shafts. In order to find an optimized shaft micro topography, the friction and wear behavior of steel and cast iron shafts with different surface treatments were compared to each other, using a combined physical (experimental) and a virtual (computational) simulation approach. The experiments were carried out with a rotary tribometer using a journal bearing test configuration with the possibility to test real-life bearing shells and shaft specimens, manufactured from real-life crankshafts. In the experiments, a polished steel shaft with low bearing wear was effective. The optimization of cast iron crankshafts by a novel surface treatment showed a significant reduction of bearing wear in relation to the classical surface finishing procedures of cast iron shafts. A computational simulation approach, considering the real-life micro topography by using the Navier–Stokes equations for the calculation of micro hydrodynamics, supports the assessment of fluid friction. The virtual simulation shows, in accordance to the experimental results, only a minor influence of the investigated shaft topographies on the fluid friction. Further optimization of shaft surfaces for journal bearing systems seems possible only by the usage of patterned micro topographies.


2019 ◽  
Vol 21 (28) ◽  
pp. 15584-15594 ◽  
Author(s):  
Vinod Kumar ◽  
Dhruvi Patel ◽  
Haridas Pal ◽  
Ketan Kuperkar

Schematic illustration depicting the aggregation phenomenon and shifts in the cationic surfactants-Congo red (CR) dye system investigated through spectral, scattering, voltammetry techniques along with the computational simulation approach.


2020 ◽  
Vol 17 ◽  
Author(s):  
Santanu Chakraborty ◽  
Manami Dhibar ◽  
Souvik Basak

Purpose: The sole purpose of this study is to improve the solubility and dissolution of telmisartan by cocrystallization technique and apply computational simulation approach to assess the nature of chemical interactions between telmisartan and coformer as well as the solvent contribution to the molecules for furnishing cocrystallization. The effects of various concentration of coformer i.e. oxalic acid on physicochemical parameters and drug release were investigated. Results: Solubility studies suggested that cocrystallization technique with oxalic acid helps to increase the solubility of pure telmisartan of about 7 folds and drug release study revealed that telmisartan-oxalic acid cocrystals showed greater dissolution as compared to pure telmisartan. SEM study suggested that prepared telmisartan cocrystals showed rhomboid-shaped crystals with sharp edges and smooth surface. FTIR study revealed that shifting in the vibrational frequencies of C=O group of telmisartan in telmisartan-oxalic acid cocrystal indicates the formation of supra molecular hetero synthon of the cocrystal. DSC and XRD study confirmed the formation of telmisartan-oxalic acid cocrystals. Computational simulation approach revealed that, telmisartan and oxalic acid can interact each other in presence of methanol and water where oxalic acid can form interactions principally with the others. The interactions, thereof, may form several associations or bondings in between the drug and carrier modifying the planarity, bond energy, bond angles of the both which subsequently lead to cocrystallization. Conclusion: So, the present research concluded that prepared telmisartan-oxalic acid cocrystal is a successful application of crystal engineering approach to improve the physicochemical properties as well as to enhance the solubility and dissolution of telmisartan.


Sign in / Sign up

Export Citation Format

Share Document