Efficacy and tolerability of antidepressants in the treatment of adolescents and young adults with depression and substance use disorders: a systematic review and meta-analysis

Addiction ◽  
2014 ◽  
Vol 110 (1) ◽  
pp. 38-48 ◽  
Author(s):  
Xinyu Zhou ◽  
Bin Qin ◽  
Cinzia Del Giovane ◽  
Junxi Pan ◽  
Salvatore Gentile ◽  
...  
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
Young Adults ◽  
Substance Use Disorders ◽  
Meta Analysis ◽  
Adolescents And Young Adults

scholarly journals Examining the Association and Directionality between Mental Health Disorders and Substance Use among Adolescents and Young Adults in the U.S. and Canada—A Systematic Review and Meta-Analysis

2018 ◽  
Vol 7 (12) ◽  
pp. 543 ◽  
Author(s):  
Sarvenaz Esmaeelzadeh ◽  
John Moraros ◽  
Lilian Thorpe ◽  
Yelena Bird
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Substance Use ◽  
Young Adults ◽  
Meta Analysis ◽  
Mental Health Disorders ◽  
Adolescents And Young Adults ◽  
Health Disorders ◽  
The U.S

Background: The purpose of this systematic review was to examine the association and directionality between mental health disorders and substance use among adolescents and young adults in the U.S. and Canada. Methods: The following databases were used: Medline, PubMed, Embase, PsycINFO, and Cochrane Library. Meta-analysis used odds ratios as the pooled measure of effect. Results: A total of 3656 studies were screened and 36 were selected. Pooled results showed a positive association between depression and use of alcohol (odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.24–1.83), cannabis (OR = 1.29, 95% CI: 1.10–1.51), and tobacco (OR = 1.65, 95% CI: 1.43–1.92). Significant associations were also found between anxiety and use of alcohol (OR = 1.54, 95% CI: 1.19–2.00), cannabis (OR = 1.36, 95% CI: 1.02–1.81), and tobacco (OR = 2.21, 95% CI: 1.54–3.17). A bidirectional relationship was observed with tobacco use at baseline leading to depression at follow-up (OR = 1.87, CI = 1.23–2.85) and depression at baseline leading to tobacco use at follow-up (OR = 1.22, CI = 1.09–1.37). A unidirectional relationship was also observed with cannabis use leading to depression (OR = 1.33, CI = 1.19–1.49). Conclusion: This study offers insights into the association and directionality between mental health disorders and substance use among adolescents and young adults. Our findings can help guide key stakeholders in making recommendations for interventions, policy and programming.

Quality of life in adolescents and young adults with CHD is not reduced: a systematic review and meta-analysis

2015 ◽  
Vol 26 (3) ◽  
pp. 415-425 ◽  
Author(s):  
Morten Schrøder ◽  
Kirsten A. Boisen ◽  
Jesper Reimers ◽  
Grete Teilmann ◽  
Jesper Brok
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Young Adults ◽  
Meta Analysis ◽  
Adolescents And Young Adults ◽  
Analysis Model ◽  
Significant Difference ◽  
Newcastle Ottawa Scale ◽  
First Time

AbstractPurposeWe performed a systematic review and meta-analysis of observational studies assessing quality of life in adolescents and young adults born with CHD compared with age-matched controls.MethodsWe carried out a systematic search of the literature published in Medline, Embase, PsychINFO, and the Cochrane Library’s Database (1990–2013); two authors independently extracted data from the included studies. We used the Newcastle–Ottawa scale for quality assessment of studies. A random effects meta-analysis model was used. Heterogeneity was assessed using the I2-test.ResultsWe included 18 studies with 1786 patients. The studies were of acceptable-to-good quality. The meta-analysis of six studies on quality of life showed no significant difference – mean difference: −1.31; 95% confidence intervals: −6.51 to +3.89, I2=90.9% – between adolescents and young adults with CHD and controls. Similar results were found in 10 studies not eligible for the meta-analysis. In subdomains, it seems that patients had reduced physical quality of life; however, social functioning was comparable or better compared with controls.ConclusionFor the first time in a meta-analysis, we have shown that quality of life in adolescents and young adults with CHD is not reduced when compared with age-matched controls.

Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis

2018 ◽  
Vol 193 ◽  
pp. 91-103 ◽  
Author(s):  
Felipe Ornell ◽  
Fernanda Hansen ◽  
Felipe Barreto Schuch ◽  
Fernando Pezzini Rebelatto ◽  
Ana Laura Tavares ◽  
...  
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
Substance Use Disorders ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor

Comorbidity of Physical Disorders Among Patients With Severe Mental Illness With and Without Substance Use Disorders: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 15 (3) ◽  
pp. 192-206 ◽  
Author(s):  
Ifeoma N. Onyeka ◽  
Margrethe Collier Høegh ◽  
Eldbjørg Marie Nåheim Eien ◽  
Bright I. Nwaru ◽  
Ingrid Melle
Keyword(s):  
Systematic Review ◽  
Mental Illness ◽  
Substance Use ◽  
Severe Mental Illness ◽  
Substance Use Disorders ◽  
Meta Analysis ◽  
Physical Disorders

Comorbidity of bipolar and substance use disorders in national surveys of general populations, 1990–2015: Systematic review and meta-analysis

2016 ◽  
Vol 206 ◽  
pp. 321-330 ◽  
Author(s):  
Glenn E. Hunt ◽  
Gin S. Malhi ◽  
Michelle Cleary ◽  
Harry Man Xiong Lai ◽  
Thiagarajan Sitharthan
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
Substance Use Disorders ◽  
Meta Analysis ◽  
National Surveys ◽  
General Populations

scholarly journals Gray and white matter morphology in substance use disorders: A neuroimaging systematic review and meta-analysis

2020 ◽  
Author(s):  
Victor Pando-Naude ◽  
Sebastian Toxto ◽  
Sofia Fernandez-Lozano ◽  
E. Christine Parsons ◽  
Sarael Alcauter ◽  
...  
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
White Matter ◽  
Substance Use Disorders ◽  
Morphological Changes ◽  
Meta Analysis ◽  
Internal Capsule ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Consumption Pattern

AbstractSubstance use disorders (SUDs) are characterized by a compulsion to seek and consume one or more substances of abuse, with a perceived loss of control and negative emotional state. Repeated use of a substance results in synaptic and morphological changes, secondary to toxicity and SUD pathology in the dopamine striato-thalamo-cortical and limbic pathways. These neuroadaptations seem to vary between studies, which could be related to divergent effects of substances, consumption severity or other unknown factors. We therefore identified studies investigating the effects of SUDs using volumetric whole-brain voxel-based morphometry (VBM) in gray (GM) and white matter (WM). We performed a systematic review and meta-analysis of VBM studies using the anatomic likelihood estimation (ALE) method implemented in GingerALE (PROSPERO pre-registration CRD42017071222). Fifty studies met inclusion criteria and were included in the final quantitative meta-analysis, with a total of 538 foci, 88 experiments and 4370 participants. We found convergence and divergence in brain regions and volume effects (higher vs lower volume) in GM and WM depending on the severity of consumption pattern and type of substance. Convergent pathology was evident across substances in GM of the insula, anterior cingulate cortex, putamen, and thalamus, and in WM of the thalamic radiation and internal capsule bundle. Divergent pathology between occasional use (cortical pathology) and addiction (cortical-subcortical pathology) provides evidence of a possible top-down neuroadaptation. Our findings indicate distinctive brain morphometry alterations in SUDs, which may inform our understanding of disease progression and ultimately therapeutic approaches.

scholarly journals Gender differences in suicidal behavior in adolescents and young adults: systematic review and meta-analysis of longitudinal studies

2019 ◽  
Vol 64 (2) ◽  
pp. 265-283 ◽  
Author(s):  
Andrea Miranda-Mendizabal ◽  
Pere Castellví ◽  
Oleguer Parés-Badell ◽  
Itxaso Alayo ◽  
José Almenara ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gender Differences ◽  
Young Adults ◽  
Longitudinal Studies ◽  
Suicidal Behavior ◽  
Meta Analysis ◽  
Adolescents And Young Adults
Sign in / Sign up

Export Citation Format

Share Document