Efficacy of Brief Intervention for harmful and hazardous alcohol use: a systematic review and meta‐analysis of studies from Low Middle‐Income countries

Addiction ◽  
2021 ◽  
Author(s):  
Abhishek Ghosh ◽  
Pranshu Singh ◽  
Nileswar Das ◽  
Pranbhat Mani Pandit ◽  
Sauvik Das ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Brief Intervention ◽  
Meta Analysis ◽  
Hazardous Alcohol Use ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Hazardous Alcohol

scholarly journals Seroprevalence of SARS CoV-2 infection in Low and Middle-Income Countries and risk classification in the context of rolling out vaccine candidate across these countries : Protocol for a systematic review and meta-analysis

2021 ◽  
Author(s):  
Martin Ackah ◽  
Louise Ameyaw ◽  
Kwadwo Owusu Akuffo ◽  
Cynthia Osei Yeboah ◽  
Nana Esi Wood ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Vaccine Candidate ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Research Database ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Low And Middle Income

Abstract Background Seroprevalence of SARS Cov-2 provides a good indication of the extent of exposure and spread in the population, as well as those likely to benefit from a vaccine candidate. To date, there is no published or ongoing systematic review on the seroprevalence of COVID-19 in Low- and Middle-Income Countries (LMICs). This systematic review and meta-analysis will estimate SARS Cov-2 seroprevalence and the risk factors for SARS Cov-2 infection in LMICs.Methods We will search PubMed, EMBASE, WHO COVID-19 Global research database, Google Scholar, the African Journals Online, LILAC, HINARI, medRxiv, bioRxiv and Cochrane Library for potentially useful studies on seroprevalence of COVID-19 in LMICs from December 2019 to December 2020 without language restriction. Two authors will independently screen all the articles, select studies based on pre-specified eligibility criteria and extract data using a pre-tested data extraction form. Any disagreements will be resolved through discussion between the authors. The pooled seroprevalence of SARS CoV-2 for people from LMICs will be calculated. Random effects model will be used in case of substantial heterogeneity in the included studies, otherwise fixed-effect model will be used. A planned subgroup, sensitivity and meta-regression analyses will be performed. For comparative studies, the analyses will be performed using Review Manager v 5.4; otherwise, STATA 16 will be used. All effect estimates will be presented with their confidence intervals.Discussion The study will explore and systematically review empirical evidence on SARS Cov-2 seroprevalence in LMICs, and to assess the risk factors for SARS Cov-2 infection in Low Middle Income Countries in the context of rolling out vaccines in these countries. Finally, explore risk classifications to help with the rolling out of vaccines in LMICs.Systematic review registration: The protocol for this review has been registered in PROSPERO (CRD422020221548).

scholarly journals Alcohol use and its determinants among adults living with HIV/AIDS in Ethiopia: a systematic review and meta-analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Birhanie Mekuriaw ◽  
Zelalem Belayneh ◽  
Alemayehu Molla ◽  
Tsegaye Mehare
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Hiv Infection ◽  
Meta Analysis ◽  
Hiv Patients ◽  
Hazardous Alcohol Use ◽  
Pooled Prevalence ◽  
Hazardous Alcohol ◽  
Hiv Aids

Abstract Background Alcohol use is a common practice of almost all communities worldwide and it is more common among persons with HIV infection. Alcohol consumption among people with HIV/AIDS may result in poor treatment adherence, further immunity suppression and increase the risk of comorbid illness (diseases) which collectively diminish the anti-retroviral therapy responses. Although there are separate studies conducted regarding alcohol use among people with HIV/AIDS in Ethiopia, the finding results are highly variable and inconsistent. Therefore, conducting a systematic review and meta-analysis has a paramount importance to show the pooled prevalence of alcohol use and to identify its determinants among people with HIV/AIDS. Methods A systematic search of electronic databases of PubMed/Medline, Science Direct, Hinnari and Cochrane library was employed. Additionally, the grey literature was searched from Google and Google Scholar. Data were extracted using a standardized data extraction format prepared in Microsoft Excel . STATA-version 14 statistical software was used for analysis. Heterogeneity of primary studies was found as evaluated using the I2 test result. As a result, a random-effect meta-analysis model was used to estimate the pooled prevalence of alcohol use. Results A total of 22 primary studies which comprises 8,368 study participants were included in this systematic review and meta-analysis. The pooled prevalence of lifetime, current and hazardous alcohol use among HIV patients in Ethiopia were 36.42% [95% CI (19.96, 52.89)], 19.00% [95% CI (12.98, 25.01)] and 21.64% [95% CI (12.72, 30.55)], respectively. Khat chewing [OR = 3.53, (95% CI 1.31, 9.51)] and cigarette smoking [OR = 7.04, (95% CI 3.53, 14.04)] were found as statistically significant determinants of hazardous alcohol use among people with HIV infection. Conclusions The result of this review showed that alcohol drinking is highly practiced among people with HIV/AIDS in Ethiopia. The magnitude of alcohol use was highly variable based on the screening methods used to measure alcohol use. Comorbid substance use (khat and cigarette) increases the risk of alcohol consumption among HIV patients. This suggests a need for designing appropriate and culturally applicable intervention programs and policy responses. Trial registration PROSPERO 2019, “CRD42019132524.”

scholarly journals Role of Iron in the Reduction of Anemia Among Women of Reproductive Age in Low-Middle Income Countries: Insights From Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Sumera Aziz Ali ◽  
Shama Razzaq ◽  
Savera Aziz ◽  
Ahreen Allana ◽  
Arzina Aziz Ali ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Reproductive Age ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Women Of Reproductive Age ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries

Abstract BackgroundIron deficiency anemia is a common public health problem problem among women of reproductive age (WRA) as it is can lead to unfavorable maternal and birth outcomes. Although studies are undertaken to assess the efficacy of iron, there are some gaps and limitations in the existing studies that need to be addressed. To address the gaps, we undertook a systematic review and meta-analysis to assess the existing evidence regarding the role of iron in decreasing anemia among WRA in low-middle-income countries.MethodsPubMed, Embase, and Science Direct were systematically searched using a comprehensive search strategy for randomized controlled trials published between 2000 to 2020. Mean change in hemoglobin level was assessed as a primary outcome. We performed a meta-analysis to estimate the pooled effect of all studies using standardized mean differences and their respective 95% CI. We assessed heterogeneity and publication bias using I2 statistics and Egger’s test respectively. This review was conducted with the help of updated guidelines based on the Preferred Reporting Items for Systematic Review and Meta-analysisResultsGenerally, the results demonstrated a favorable effect of iron therapy in improving hemoglobin levels with variation across studies. An overall pooled effect estimate for the role of iron therapy in decreasing the burden of anemia among WRA was -0.51 (95% CI: -1.03 to 0.01) (p = 0.04). Likewise, iron therapy improved ferritin levels and decreased the prevalence of anemia. The heterogeneity across included studies was found to be statistically significant as indicated by the parameters of heterogeneity (Q = 1191.60, I2 = 98.24%, p = 0.000). ConclusionIron therapy in any form may reduce the burden of anemia and improve the hemoglobin and ferritin levels, indicating improvement in iron-deficiency anemia. However, more evidence is needed to assess the morbidity associated with iron consumption such as side effects, work performance, economic outcomes, mental health, and compliance to the intervention with a special focus on married but non-pregnant women planning a pregnancy in near future. A systematic review and Meta-analysis registration: Registered with PROSPERO and ID is CRD42020185033

Shock in Children in Low (Middle) Income Countries: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Roxanne Assies ◽  
Ilse Snik ◽  
Yamikani Chimalizeni ◽  
Mercy Kumwenda ◽  
Josephine Langton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries

Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis

2018 ◽  
Vol 47 ◽  
pp. 310-319 ◽  
Author(s):  
Keren Mandelzweig ◽  
Aleksandra Leligdowicz ◽  
Srinivas Murthy ◽  
Rejani Lalitha ◽  
Robert A. Fowler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Invasive Ventilation ◽  
Middle Income ◽  
Middle Income Countries ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Low Middle Income Countries

Interventions to Reduce Alcohol Harms in Low and Middle Income Countries: a Systematic Review and Meta Analysis

2018 ◽  
Author(s):  
Joao Ricardo Nickenig Vissoci
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Randomized Controlled Trials ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Middle Income ◽  
Brief Motivational Intervention ◽  
Randomized Controlled

BackgroundHarmful alcohol use leads to a large burden of disease and disability which disportionately impacts LMICs. The World Health Organization and the Lancet have issued calls for this burden to be addressed, but issues remain, primarily due to gaps in information. While a variety of interventions have been shown to be effective at reducing alcohol use in HICs, their efficacy in LMICs have yet to be assessed. This systematic review describes the current published literature on alcohol interventions in LMICs and conducts a meta analysis of clinical trials evaluating interventions to reduce alcohol use and harms in LMICs.MethodsIn accordance with PRISMA guidelines we searched the electronic databases Pubmed, EMBASE, Scopus,Web of Science, Cochrane, and Psych Info. Articles were eligible if they evaluated an intervention targeting alcohol-related harm in LMICs. After a reference and citation analysis, we conducted a quality assessment per PRISMA protocol. A meta-analysis was performed on the 39 randomized controlled trials that evaluated an alcohol-related outcome.ResultsOf the 3,801 articles from the literature search, 87 articles from 25 LMICs fit the eligibility and inclusion criteria. Of these studies, 39 randomized controlled trials were included in the meta-analysis. Nine of these studies focused specifically on medication, while the others focused on brief motivational intervention, brain stimulation, AUDIT-based brief interventions, WHO ASSIST-based interventions, group based education, basic screening and interventions, brief psychological or counseling, dyadic relapse prevention, group counseling, CBT, motivational + PTSD based interview, and health promotion/awareness. Conclusion Issues in determining feasible options specific to LMICs arise from unstandardized interventions, unequal geographic distribution of intervention implementation, and uncertain effectiveness over time. Current research shows that brain stimulation, psychotherapy, and brief motivational interviews have the potential to be effective in LMIC settings, but further feasibility testing and efforts to standardize results are necessary to accurately assess their effectiveness.

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