Genetic liability for Prescription Opioid Use and Risk of Cardiovascular Diseases: A Multivariable Mendelian Randomization Study

Addiction ◽  
2021 ◽  
Author(s):  
Jiahao Cai ◽  
Lei He ◽  
Hongxuan Wang ◽  
Xiaoming Rong ◽  
Ming Chen ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Mendelian Randomization ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Genetic Liability ◽  
Prescription Opioid Use

scholarly journals 0049 Within-person predictors of same day alcohol and prescription opioid use among youth presenting to an urban emergency department

2021 ◽  
Author(s):  
J Goldstick ◽  
E Bonar ◽  
M Myers ◽  
A Bohnert ◽  
M Walton ◽  
...  
Keyword(s):  
Emergency Department ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Prescription Opioid Use ◽  
Urban Emergency Department

“Doctor and pharmacy shopping”: A fading signal for prescription opioid use monitoring?

2021 ◽  
Vol 221 ◽  
pp. 108618
Author(s):  
Chris Delcher ◽  
Daniel R. Harris ◽  
Changwe Park ◽  
Gail K. Strickler ◽  
Jeffery Talbert ◽  
...  
Keyword(s):  
Prescription Opioid ◽  
Opioid Use ◽  
Prescription Opioid Use

scholarly journals Opioid dosing among patients with 3 or more years of continuous prescription opioid use before and after the CDC opioid prescribing guideline

2021 ◽  
Vol 97 ◽  
pp. 103308
Author(s):  
Joanne Salas ◽  
Xue Li ◽  
Hong Xian ◽  
Mark D. Sullivan ◽  
Jane C. Ballantyne ◽  
...  
Keyword(s):  
Prescription Opioid ◽  
Opioid Use ◽  
Opioid Prescribing ◽  
Before And After ◽  
Prescription Opioid Use

The association of prescription opioid use with incident cancer: A surveillance, epidemiology, and end results‐medicare population‐based case‐control study

Cancer ◽  
2020 ◽  
Author(s):  
Jeana E. Havidich ◽  
Julie E. Weiss ◽  
Tracy L. Onega ◽  
Ying H. Low ◽  
Martha E. Goodrich ◽  
...  
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Medicare Population ◽  
Incident Cancer ◽  
Prescription Opioid Use ◽  
Control Study ◽  
End Results

354 Trends in the Drug-Sparing Effects for Benzodiazepines and Prescription Opioids among Insomnia Patients on Suvorexant in the US

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A141-A141
Author(s):  
Hrishikesh Kale ◽  
Rezaul Khandker ◽  
Ruchit Shah ◽  
Marc Botteman ◽  
Weilin Meng ◽  
...  
Keyword(s):  
Interrupted Time Series ◽  
Charlson Comorbidity Index Score ◽  
Prescription Opioid ◽  
Prescription Opioids ◽  
Opioid Use ◽  
Before And After ◽  
Prescription Opioid Use ◽  
Incident Cohort ◽  
Over Time ◽  
Post Period

Abstract Introduction Use of benzodiazepines to treat insomnia has been associated with serious side effects and abuse potential. Insomnia patients are at high risk of opioid abuse and better sleep patterns may help to reduce opioid use. This study examined the trend in the use of benzodiazepines and prescription opioids before and after initiation of suvorexant in insomnia patients. Methods The study analyzed 2015–2019, Optum Clinformatics Data Mart. Insomnia patients, identified using ICD-9/10 codes and prescribed suvorexant were included. The study included incident (newly diagnosed) and prevalent cohorts of insomnia patients. The proportion of patients on benzodiazepines or prescription opioids were calculated for 12 monthly intervals before (pre-period) and after initiation of suvorexant (post-period). Interrupted time series (ITS) analysis was conducted to assess trends for use of benzodiazepine or prescription opioids over time. Results A total of 5,939 patients from the incident insomnia cohort and 18,920 from the prevalent cohort were included. For the incident cohort, mean age was 64.47 (SD: 15.48), 63% were females, 71% had Medicare Advantage coverage, 59% had Charlson comorbidity index score (CCI) ≥ 1, 27% had an anxiety disorder and 16% had substance abuse disorder. Prevalent insomnia cohort was similar but had higher CCI. Results from ITS suggested that at the beginning of the pre-period, 28% of incident insomnia patients used either opioids or benzodiazepines with the rate of use in the pre-period increasing by 0.11% per month. In the post-period, the rate of use decreased by 0.33% per month. About 26% patients used benzodiazepines or opioids at 12-month after suvorexant initiation. In the absence of suvorexant, this proportion would have been 31%. Similar findings were observed for the prevalent insomnia cohort. A larger decrease was observed for opioid use than benzodiazepines. Conclusion The rate of benzodiazepines or prescription opioid use decreased over time after the initiation of suvorexant. Suvorexant has the potential to reduce the use of opioids and benzodiazepines among insomnia patients. Further research is needed to confirm these findings. Support (if any) This study was sponsored by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.

Chronic prescription opioid use in pregnancy in the United States

2021 ◽  
Author(s):  
Loreen Straub ◽  
Krista F. Huybrechts ◽  
Sonia Hernandez‐Diaz ◽  
Yanmin Zhu ◽  
Seanna Vine ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Prescription Opioid Use ◽  
In Pregnancy

Prescription opioid use in Australian women of reproductive age: implications for unplanned pregnancies

2021 ◽  
Author(s):  
Bianca Varney ◽  
Helga Zoega ◽  
Malcolm Bjørn Gillies ◽  
Jonathan Brett ◽  
Sallie‐Anne Pearson ◽  
...  
Keyword(s):  
Reproductive Age ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Women Of Reproductive Age ◽  
Unplanned Pregnancies ◽  
Prescription Opioid Use

Association between Lifetime History of Traumatic Brain Injury, Prescription Opioid Use, and Persistent Pain: A Nationally Representative Study

2021 ◽  
Author(s):  
Raj G. Kumar ◽  
Katherine A. Ornstein ◽  
John D. Corrigan ◽  
Rachel Sayko Adams ◽  
Kristen Dams-O'Connor
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Persistent Pain ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Lifetime History ◽  
Representative Study ◽  
History Of ◽  
Nationally Representative ◽  
Prescription Opioid Use
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