Androgen and oestrogen receptors in the growing antlers velvet of adult and yearling pampas deer ( Ozotoceros bezoarticus ) males

2021 ◽  
Author(s):  
Alejandro Bielli ◽  
Aline Freitas‐de‐Melo ◽  
Patricia Genovese ◽  
Matías Villagrán ◽  
Celia Tasende ◽  
...  
Keyword(s):  
Oestrogen Receptors ◽  
Ozotoceros Bezoarticus

Nuclear receptors in disease: the oestrogen receptors

2004 ◽  
Vol 40 ◽  
pp. 157-167 ◽  
Author(s):  
Maria Nilsson ◽  
Karin Dahlman-Wright ◽  
Jan-Åke Gustafsson
Keyword(s):  
Nuclear Receptors ◽  
Target Genes ◽  
Receptor Subtype ◽  
Target Tissue ◽  
Oestrogen Receptors ◽  
Nucleotide Polymorphisms ◽  
Cell Type ◽  
Single Nucleotide ◽  
Beneficial Effects ◽  
The Family

For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knockout (ERKO) mice have been instrumental in defining the relevance of a given receptor subtype in a certain tissue. Phenotypes displayed by ERKO mice suggest diseases in which dysfunctional ERs might be involved in aetiology and pathology. Association between single-nucleotide polymorphisms (SNPs) in ER genes and disease have been demonstrated in several cases. Selective ER modulators (SERMs), which are selective with regard to their effects in a certain cell type, already exist. Since oestrogen has effects in many tissues, the goal with a SERM is to provide beneficial effects in one target tissue while avoiding side effects in others. Refined SERMs will, in the future, provide improved therapeutic strategies for existing and novel indications.

Oestrogen receptors, clinical features and prognosis in stage III breast cancer

1982 ◽  
Vol 18 (12) ◽  
pp. 1315-1320 ◽  
Author(s):  
John F. Stewart ◽  
Roger J.B. King ◽  
Peter J. Winter ◽  
David Tong ◽  
John L. Hayward ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Features ◽  
Stage Iii ◽  
Oestrogen Receptors ◽  
Stage Iii Breast Cancer

Oestrogen receptors in the rat adrenal gland

1978 ◽  
Vol 9 (10) ◽  
pp. 957-962 ◽  
Author(s):  
R.S. Calandra ◽  
O. Naess ◽  
K. Purvis ◽  
A. Attramadal ◽  
O. Djøseland ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Oestrogen Receptors

Cloning, characterisation, and expression of three oestrogen receptors (ERα, ERβ1 and ERβ2) in the European sea bass, Dicentrarchus labrax

2004 ◽  
Vol 223 (1-2) ◽  
pp. 63-75 ◽  
Author(s):  
S. Halm ◽  
G. Martı́nez-Rodrı́guez ◽  
L. Rodrı́guez ◽  
F. Prat ◽  
C.C. Mylonas ◽  
...  
Keyword(s):  
Dicentrarchus Labrax ◽  
Sea Bass ◽  
Oestrogen Receptors ◽  
European Sea Bass

scholarly journals The effect of long-term treatment with steroid hormones or tamoxifen on oestrogen receptors (alpha and beta) in the endometrium of ovariectomized cynomolgus macaques

2002 ◽  
Vol 175 (3) ◽  
pp. 673-681 ◽  
Author(s):  
H Wang ◽  
E Isaksson ◽  
B Von Schoultz ◽  
JM Cline ◽  
L Sahlin
Keyword(s):  
Hormone Treatment ◽  
Term Treatment ◽  
Response To Treatment ◽  
Oestrogen Receptors ◽  
Minor Variation ◽  
Protein Levels ◽  
Long Term Treatment ◽  
High Level ◽  
Er Alpha

The effects of oestrogen are mediated by two specific intracellular receptors, oestrogen receptors (ER) alpha and beta, which function as ligand-activated transcriptional regulators. Ovariectomized macaques (Macaca fascicularis) were used to study the regulation of ERalpha and ERbeta in the endometrium by immunohistochemistry and in situ hybridization after long-term hormone treatment. Animals were treated continuously for 35 Months with either conjugated equine oestrogen (CEE), medroxyprogesterone acetate (MPA), combined CEE/MPA, or tamoxifen (TAM). Treatment with CEE/MPA down-regulated ERalpha in the superficial glands. In the superficial stroma the ERalpha level was lower in the CEE/MPA group than in the CEE and MPA groups. ERbeta immunostaining was faint with minor variation in response to treatment, but increased in the superficial stroma after MPA treatment. The ratio of ERbeta/ERalpha increased in superficial stroma and gland after CEE/MPA treatment, and also in stroma after MPA and TAM. Cystic endometrial hyperplasia was observed in TAM-treated animals, in combination with a high level of ERalpha protein expression. The present data show that long-term hormone treatment affects the ERalpha and ERbeta protein levels in the endometrium. The balance between ERalpha and ERbeta seems to be important for the proliferative response to oestrogen.

Sign in / Sign up

Export Citation Format

Share Document