Developmental origins and transgenerational inheritance of polycystic ovary syndrome

2021 ◽  
Author(s):  
Jim Parker ◽  
Claire O’Brien ◽  
Felice L. Gersh
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Developmental Origins ◽  
Transgenerational Inheritance ◽  
Ovary Syndrome

scholarly journals Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

2020 ◽  
Vol 41 (4) ◽  
pp. 538-576 ◽  
Author(s):  
Elisabet Stener-Victorin ◽  
Vasantha Padmanabhan ◽  
Kirsty A Walters ◽  
Rebecca E Campbell ◽  
Anna Benrick ◽  
...  
Keyword(s):  
Animal Models ◽  
Polycystic Ovary Syndrome ◽  
Genetic Manipulation ◽  
Polycystic Ovary ◽  
Developmental Origins ◽  
Metabolic Dysfunction ◽  
Ovary Syndrome ◽  
Naturally Occurring ◽  
High Prevalence

Abstract More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.

scholarly journals Polycystic ovary syndrome and its developmental origins

2007 ◽  
Vol 8 (2) ◽  
pp. 127-141 ◽  
Author(s):  
Daniel A. Dumesic ◽  
David H. Abbott ◽  
Vasantha Padmanabhan
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Developmental Origins ◽  
Ovary Syndrome
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