Berberine ameliorates erectile dysfunction in rats with streptozotocin‐induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways

Diabetes mellitus causes hypertonicity, increased plasma arginine vasopressin (AVP), polydipsia, and polyuria. Downregulation of AVP V2 receptors may contribute to the polyuria through diminished V2 receptor-mediated free water retention. After 2 wk of streptozotocin-induced diabetes mellitus, the diabetic rats had raised plasma glucose, AVP, and osmolality levels (P < 0.001) compared with nondiabetic controls (Sham). Insulin treatment (4 U long-acting insulin sc, daily) partially lowered these values (P < 0.01). There was a reduction in the number of renal and hepatic V1 receptors in the diabetic and diabetic+insulin animals compared with the sham animals (P < 0.05). The receptor affinity remained unchanged. In parallel, there was a reduction in maximum AVP-activated total inositol phosphate production in the liver and kidney of the diabetic and diabetic+insulin animals compared with the sham animals (P < 0.05). The density and affinity of renal V2 receptors and AVP-stimulated adenosine 3',5'-cyclic monophosphate production in the diabetic and diabetic+insulin animals were unchanged compared with the sham. These results demonstrate differential regulation of AVP receptors and suggest that downregulation of renal V2 receptors does not contribute to the polyuria of diabetes. In contrast, downregulation of V1 receptors might contribute to diminished V1 receptor-mediated biological responses to AVP seen in diabetes mellitus.

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The Experience of Indonesian Men Living with Type-2 Diabetes Mellitus and Erectile Dysfunction: A Semi-structured Interview Study

Sexuality and Disability ◽

10.1007/s11195-021-09687-y ◽

2021 ◽

Vol 39 (2) ◽

pp. 245-260

Author(s):

Setho Hadisuyatmana ◽

Ferry Efendi ◽

Eka Mishbahatul Marah Has ◽

Sylvia Dwi Wahyuni ◽

Michael Bauer ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Erectile Dysfunction ◽

Structured Interview ◽

Interview Study

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Effect of streptozotocin-induced diabetes mellitus on serotonin measures of peripheral tissues in rats

Life Sciences ◽

10.1016/0024-3205(94)00407-j ◽

1994 ◽

Vol 56 (1) ◽

pp. 51-59 ◽

Cited By ~ 26

Author(s):

F.J. Marti´n ◽

J.M. Mi´guez ◽

M. Aldegunde ◽

G. Atienza

Keyword(s):

Diabetes Mellitus ◽

Peripheral Tissues ◽

Streptozotocin Induced Diabetes

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The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2017-0055 ◽

2017 ◽

Vol 95 (11) ◽

pp. 1343-1350

Author(s):

Aleksandra Vranic ◽

Stefan Simovic ◽

Petar Ristic ◽

Tamara Nikolic ◽

Isidora Stojic ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systolic Function ◽

Diabetic Rats ◽

Diabetic Rat ◽

Albino Rats ◽

Acute Administration ◽

Rat Hearts ◽

Patients With Diabetes ◽

Streptozotocin Induced Diabetes ◽

Wistar Albino Rats

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.

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