The Promise of viral phage therapy in hernia mesh infection, is this the biological ‘silver bullet’ of the future?

2020 ◽  
Vol 90 (11) ◽  
pp. 2161-2164
Author(s):  
Peter Speck ◽  
Morgyn Warner ◽  
Jason Clark ◽  
Anita Jacombs ◽  
Alex Karatassas ◽  
...  
Author(s):  
Anna Birney

AbstractMore and more people and organisations who are addressing complex sustainability challenges are turning to systems change practices. They are looking to get to grips with complexity and to better understand how to use their resources, position and influence to address the challenges. These people are working across civil society, philanthropy, business, international development, government and beyond. Many hope that adopting this emerging practice will give them the answers to the long held questions of – How do I know where to intervene? How do I know that what I am doing is the ‘right’ thing? Am I using my resources for their greatest effect? Once we have set ambitious goals around issues like inequality and climate change, how do I know I am creating impact?. In 1999 Donella Meadows wrote a paper entitled Leverage points: places to intervene in a system to help translate the work of systems dynamics into understanding where a small amount of energy might have a greater effect. Ever since, practitioners have been chasing these elusive leverage points trying to understand how this might be made useful and practical. There is, however, no silver bullet to changing a system. At Forum for the Future and through the School of System Change, we work on a number of different projects such as the Protein Challenge and Boundless Roots Community as well as collaborate on, coach and co-inquire with others such as the Marine CoLAB, Oneless, Lankelly Chase Foundation. In this paper we seek to build on systems change ideas and theories, using Forum for the Future experience of working with these ideas in practice, and offer actionable knowledge (Coghlan 2007) to other change makers who are grappling with these questions. This paper provides four qualities that help us understand the dynamics of a changing system, and how potential in these dynamics might be identified and be translated into strategy and interventions. I explore and illustrate these through cases and examples and raise the question about how change makers might value what we measure when understanding impact in the context of a changing system.


Author(s):  
Daniel Brandon Jr.

“Reuse [software] engineering is a process where a technology asset is designed and developed following architectural principles, and with the intent of being reused in the future” (Bean, 1999). “If programming has a Holy Grail, widespread code reuse is it with a silver bullet. While IT has made and continues to make laudable progress in our reuse, we never seem to make great strides in this area” (Grinzo, 1998). “The quest for that Holy Grail has taken many developers over many years down unproductive paths” (Bowen, 1997). This article is an overview of software reuse methods, particularly object oriented, that have been found effective in business systems over the years.


Author(s):  
Larissa Hjorth ◽  
Kana Ohashi ◽  
Jolynna Sinanan ◽  
Sarah Pink ◽  
Heather Horst ◽  
...  

In Chapter 8 we turn to Co-futuring Kinship—the ways in which past and present practices inform how the future of the kinship for care at a distance. This is particularly important for “super-aging” contexts like Japan in which one in three is of 80 years old. Chapter 8 sets the picture for discussion around digital health in which mobile media is fully imbricated in. Discussions around a “silver bullet” in the form of a mobile app still dominate despite the fact that there is much work into the need for social, rather than technological, solutions.


2011 ◽  
Vol 148 (5) ◽  
pp. e392-e394 ◽  
Author(s):  
H. Johanet ◽  
N. Contival

2013 ◽  
Vol 8 (6) ◽  
pp. 769-783 ◽  
Author(s):  
Benjamin K Chan ◽  
Stephen T Abedon ◽  
Catherine Loc-Carrillo
Keyword(s):  

Author(s):  
Daniel Brandon

“Reuse [software] engineering is a process where a technology asset is designed and developed following architectural principles, and with the intent of being reused in the future” (Bean, 1999). “If programming has a Holy Grail, wide-spread code reuse is it with a silver bullet. While IT has made and continues to make laudable progress in our reuse, we never seem to make great strides in this area” (Grinzo, 1998). “The quest for that Holy Grail has taken many developers over many years down unproductive paths” (Bowen, 1997). This article is an overview of software reuse methods, particularly object oriented, that have been found effective in business systems over the years.


2012 ◽  
Vol 61 (2) ◽  
Author(s):  
Bert Rürup

AbstractPoverty in old age is, up to now, not a relevant social problem in Germany.Nevertheless, there are clear indications that poverty among the elderly will increase in the future due to a bundle of reasons. Because of this there is no silver bullet to solve this problem. In the conception of an adequate strategy to reduce and to prevent a rise of poverty in old age, however, the equivalence principle as the basic principal the German statutory pension scheme has to be questioned critically.


2020 ◽  
Vol 10 (21) ◽  
pp. 7654
Author(s):  
Junwei Wei ◽  
Nan Peng ◽  
Yunxiang Liang ◽  
Keke Li ◽  
Yingjun Li

Antibiotic-resistant bacteria infections pose a threat to public health. Considering the difficulty in developing new antibiotics, it is an urgent need to develop alternative therapies against bacterial pathogens. Bacteriophages (phages) are evaluated as potential substitutes or adjuncts of antibiotics because they are abundant in nature and could specifically lyse bacteria. In this review, we briefly introduce phage therapy and its advantages compared with traditional antibiotic therapy. We also summarize new emerging phage technologies, such as CRISPR-Cas, synthetic phages, etc., and discuss some possible obstacles and potential risks in the application process. We believe that, with the advancement in synthetic biology and delivery technology, phage therapy has broad prospects in the future.


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