Disseminated leptomeningeal spread of sinonasal adenocarcinoma of the intestinal type

2021 ◽  
Author(s):  
Jamie Miller ◽  
Rowan Valentine ◽  
Ema Knight ◽  
Jorn Van Der Veken
Keyword(s):  
Intestinal Type ◽  
Leptomeningeal Spread ◽  
Sinonasal Adenocarcinoma

A Case of Papillary Intestinal Type Sinonasal Adenocarcinoma of the Nasal Cavity

2013 ◽  
Vol 56 (5) ◽  
pp. 310 ◽  
Author(s):  
Chan Goo Lee ◽  
Young Joo Park ◽  
Susie Chin ◽  
Jae Yong Lee
Keyword(s):  
Nasal Cavity ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

scholarly journals Recurrent DNA copy number alterations in intestinal-type sinonasal adenocarcinoma

2016 ◽  
Vol 54 (3) ◽  
pp. 278-286
Author(s):  
J. Perez-Escuredo ◽  
A. Lopez-Hernandez ◽  
M. Costales ◽  
F. Lopez ◽  
S.P. Ares ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Copy Number ◽  
Genetic Alterations ◽  
Intestinal Type ◽  
Dust Exposure ◽  
Copy Number Alterations ◽  
A Genome ◽  
Sinonasal Adenocarcinoma ◽  
Gains And Losses ◽  
Microarray Cgh

Background: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour related to occupational wood dust exposure. Few studies have described recurrent genetic changes on a genome-wide scale. The aim of this study was to obtain a high resolution map of recurrent genetic alterations in ITAC. Material and methods: Copy number alterations were evaluated by microarray CGH and MLPA in 37 primary tumours. The results were correlated with pathological characteristics and clinical outcome. Results: Microarray CGH identified the following recurrent aberrations, in descending order: gains at 5p15 (22 cases, 60%), 8q24 (21 cases, 57%), 20q13 (20 cases, 54%), 20q11, and 8q21 (19 cases, 51%), 20p13, and 7p11 (16 cases, 43%), and losses at 5q11-qter, 8p12-pter, and 18q12-23 (15 cases, 40%), and 17p13, and 19p13 (13 cases, 35%). MLPA analysis confirmed this global pattern of gains and losses. Chromosomal loss at 4q32-ter and gains at 1q22, 6p22 and 3q29, as well as deletion of TIMP2 and CRK correlated with unfavourable clinical outcome. Conclusion: ITACs have a unique pattern of chromosomal abnormalities. The four different histological subtypes of ITAC appeared genetically similar. Four chromosomal gains and losses and two specific genes showed prognostic value and may be involved in tumour progression.

P18 Clinical management of intestinal-type sinonasal adenocarcinoma: A monoinstitutional experience of 165 cases

Oral Oncology ◽  
2015 ◽  
Vol 51 (5) ◽  
pp. e48
Author(s):  
M. Costales ◽  
F. López ◽  
B. Vivanco ◽  
C. García-Inclán ◽  
A. López-Hernández ◽  
...  
Keyword(s):  
Clinical Management ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

scholarly journals Establishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma

2011 ◽  
Vol 34 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Jhudit Pérez-Escuredo ◽  
Jorge García Martínez ◽  
Cristina García-Inclán ◽  
Blanca Vivanco ◽  
María Costales ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Genetic Characterization ◽  
Tumor Cell Line ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

scholarly journals A case of chemotherapy-resistant intestinal-type sinonasal adenocarcinoma treated by gamma knife radiosurgery

2017 ◽  
Vol 10 ◽  
pp. 135-137
Author(s):  
Andres M. Alvarez-Pinzon ◽  
Jose E. Valerio ◽  
Beatriz E. Amendola ◽  
Devi Lakhlani ◽  
Alan A. Stein ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Intestinal Type ◽  
Sinonasal Adenocarcinoma

Intestinal-type sinonasal adenocarcinoma: a sporadic case

1996 ◽  
Vol 110 (8) ◽  
pp. 805-810 ◽  
Author(s):  
Andrej Böör ◽  
Ivan Jurkovič ◽  
Katarína Dudríková ◽  
Vojtech Kavečanský ◽  
Imrich Friedmann
Keyword(s):  
Nasal Septum ◽  
Chromogranin A ◽  
Sporadic Case ◽  
Intestinal Type ◽  
Wood Dust ◽  
Tubular Adenocarcinoma ◽  
Dust Inhalation ◽  
Sinonasal Adenocarcinoma ◽  
History Of ◽  
Columnar Cells

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

scholarly journals EGFR Expression and KRAS and BRAF Mutational Status in Intestinal-Type Sinonasal Adenocarcinoma

2013 ◽  
Vol 14 (3) ◽  
pp. 5170-5181 ◽  
Author(s):  
Vanessa Szablewski ◽  
Jérôme Solassol ◽  
Flora Poizat ◽  
Marion Larrieux ◽  
Louis Crampette ◽  
...  
Keyword(s):  
Intestinal Type ◽  
Egfr Expression ◽  
Mutational Status ◽  
Sinonasal Adenocarcinoma

scholarly journals Sinonasal Adenocarcinoma, Intestinal-Type

2020 ◽  
Author(s):  
Keyword(s):  
Intestinal Type ◽  
Sinonasal Adenocarcinoma
Sign in / Sign up

Export Citation Format

Share Document