Glucose homeostasis, beta cell function, and insulin resistance in relation to vitamin D status after gestational diabetes mellitus

Abstract Background Arsenic exposure has been associated with gestational diabetes mellitus. However, the extent to which arsenic exposure during pregnancy is associated with postpartum glucose intolerance is unknown. Methods We studied 323 women in Bangladesh. We assessed arsenic exposure in early pregnancy via toenail and water samples. We measured fasting glucose and insulin in serum at a mean (SD) of 4.0 (3.5) weeks post-delivery. We ran covariate-adjusted, linear regression models to examine associations of arsenic concentrations with HOMA-IR, a marker of insulin resistance, and HOMA-β, a marker of beta cell function. Results Median (IQR) arsenic concentration was 0.45 (0.67) μg/g in toenails and 2.0 (6.5) μg/L in drinking water. Arsenic concentrations during pregnancy were not associated with insulin resistance or beta cell function postpartum. HOMA-IR was 0.07% (− 3.13, 3.37) higher and HOMA-β was 0.96% (− 3.83, 1.99) lower per IQR increment in toenail arsenic, but effect estimates were small and confidence intervals crossed the null. Conclusions Although arsenic exposure during pregnancy has been consistently associated with gestational diabetes mellitus, we found no clear evidence for an adverse effect on postpartum insulin resistance or beta cell function.

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Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

Diabetologia ◽

10.1007/s00125-013-3048-0 ◽

2013 ◽

Vol 56 (12) ◽

pp. 2753-2760 ◽

Cited By ~ 35

Author(s):

Anny H. Xiang ◽

Miwa Takayanagi ◽

Mary Helen Black ◽

Enrique Trigo ◽

Jean M. Lawrence ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Sensitivity ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Beta Cell ◽

Beta Cell Function ◽

Cell Function ◽

Longitudinal Changes ◽

History Of

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Hypovitaminosis D in Gestational Diabetes Mellitus: The Impact of Vitamin D Status on Insulin Resistance, Parathyroid Hormone, and Perinatal Outcome

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i1.112 ◽

2018 ◽

Vol 6 (1) ◽

Author(s):

Mohamed A Youssry MD ◽

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Vitamin D ◽

Parathyroid Hormone ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Perinatal Outcome ◽

Hypovitaminosis D ◽

Vitamin D Status ◽

The Impact

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Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0036-1584566 ◽

2016 ◽

Vol 38 (06) ◽

pp. 287-292 ◽

Cited By ~ 4

Author(s):

Yun Huang ◽

Chen Fang ◽

Zhimin Ma ◽

Heming Guo ◽

Ruihua Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Beta Cell ◽

Pregnant Women ◽

Beta Cell Function ◽

Cell Function

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The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression

Immunopharmacology and Immunotoxicology ◽

10.1080/08923973.2020.1782426 ◽

2020 ◽

Vol 42 (4) ◽

pp. 366-372

Author(s):

Yuan Li ◽

Bide Duan ◽

Ying Li ◽

Shujun Yu ◽

Yanyun Wang

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Beta Cell ◽

Beta Cell Function ◽

Cell Function

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Maternal Vitamin D Status in Gestational Diabetes Mellitus Women

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1931079 ◽

2021 ◽

pp. 55-63

Author(s):

Zainedeen Nassar ◽

Mazen Alzaharna

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Blood Pressure ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Gaza Strip ◽

Density Lipoprotein ◽

Vitamin D Status

Aims: To assess vitamin D status among Gestational Diabetes Mellitus pregnant women in Gaza Strip. Study Design: Case control study. Place and Duration of Study: Samples were collected from pregnant women attending primary health care centers, Gaza, Gaza Strip. Methodology: The study comprised 90 participants, 45 GDM pregnant women and 45 apparently healthy pregnant women. Serum vitamin D and insulin levels were measured by ELISA, fasting blood glucose (FBG), 2 h oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), triglycerides (TG), cholesterol, high-density lipoprotein (HDL), phosphorus and calcium were determined chemically. Blood pressure was measured. Body mass index (BMI) and low-density lipoprotein (LDL) were calculated. Ethical approval was acquired from Helsinki committee. All data was analyzed using the SPSS program. Results: The average vitamin D in GDM cases was lower than that in controls (P=0.031). There was an increase in the average of FBG, OGTT, HbA1c and insulin levels in GDM cases versus controls (P<0.001). The average levels of serum cholesterol, TG and LDL were significantly higher in cases as compared to controls. The average systolic and diastolic blood pressure levels were higher in GDM cases in relation to controls. Pearson correlation test showed a significant negative correlation between vitamin D and the parameters: BMI, glucose, OGTT, HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Conclusion: Vitamin D was lower in GDM women compared to controls. Low vitamin D status may be associated with insulin resistance and act as a risk factor for GDM.

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Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2021-002287 ◽

2021 ◽

Vol 9 (1) ◽

pp. e002287

Author(s):

Qiulun Zhou ◽

Ying Wang ◽

Yuqin Gu ◽

Jing Li ◽

Hui Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Beta Cell ◽

Genetic Variants ◽

Cell Function ◽

Chinese Women ◽

Risk Scores ◽

Nucleotide Polymorphisms ◽

Mediation Analyses

IntroductionTo investigate associations between genetic variants related to beta-cell (BC) dysfunction or insulin resistance (IR) in type 2 diabetes (T2D) and bile acids (BAs), as well as the risk of gestational diabetes mellitus (GDM).Research design and methodsWe organized a case-control study of 230 women with GDM and 217 without GDM nested in a large prospective cohort of 22 302 Chinese women in Tianjin, China. Two weighted genetic risk scores (GRSs), namely BC-GRS and IR-GRS, were established by combining 39 and 23 single nucleotide polymorphisms known to be associated with BC dysfunction and IR, respectively. Regression and mediation analyses were performed to evaluate the relationship of GRSs with BAs and GDM.ResultsWe found that the BC-GRS was inversely associated with taurodeoxycholic acid (TDCA) after adjustment for confounders (Beta (SE)=−0.177 (0.048); p=2.66×10−4). The BC-GRS was also associated with the risk of GDM (OR (95% CI): 1.40 (1.10 to 1.77); p=0.005), but not mediated by TDCA. Compared with individuals in the low tertile of BC-GRS, the OR for GDM was 2.25 (95% CI 1.26 to 4.01) in the high tertile. An interaction effect of IR-GRS with taurochenodeoxycholic acid (TCDCA) on the risk of GDM was evidenced (p=0.005). Women with high IR-GRS and low concentration of TCDCA had a markedly higher OR of 14.39 (95% CI 1.59 to 130.16; p=0.018), compared with those with low IR-GRS and high TCDCA.ConclusionsGenetic variants related to BC dysfunction and IR in T2D potentially influence BAs at early pregnancy and the development of GDM. The identification of both modifiable and non-modifiable risk factors may facilitate the identification of high-risk individuals to prevent GDM.

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