scholarly journals Maternal Vitamin D Status in Gestational Diabetes Mellitus Women

2021 ◽  
pp. 55-63
Author(s):  
Zainedeen Nassar ◽  
Mazen Alzaharna
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Gaza Strip ◽  
Density Lipoprotein ◽  
Vitamin D Status

Aims: To assess vitamin D status among Gestational Diabetes Mellitus pregnant women in Gaza Strip. Study Design: Case control study. Place and Duration of Study: Samples were collected from pregnant women attending primary health care centers, Gaza, Gaza Strip. Methodology: The study comprised 90 participants, 45 GDM pregnant women and 45 apparently healthy pregnant women. Serum vitamin D and insulin levels were measured by ELISA, fasting blood glucose (FBG), 2 h oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), triglycerides (TG), cholesterol, high-density lipoprotein (HDL), phosphorus and calcium were determined chemically. Blood pressure was measured. Body mass index (BMI) and low-density lipoprotein (LDL) were calculated. Ethical approval was acquired from Helsinki committee. All data was analyzed using the SPSS program. Results: The average vitamin D in GDM cases was lower than that in controls (P=0.031). There was an increase in the average of FBG, OGTT, HbA1c and insulin levels in GDM cases versus controls (P<0.001). The average levels of serum cholesterol, TG and LDL were significantly higher in cases as compared to controls. The average systolic and diastolic blood pressure levels were higher in GDM cases in relation to controls. Pearson correlation test showed a significant negative correlation between vitamin D and the parameters: BMI, glucose, OGTT, HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Conclusion: Vitamin D was lower in GDM women compared to controls. Low vitamin D status may be associated with insulin resistance and act as a risk factor for GDM.

scholarly journals Vitamin D status and risk factors among pregnancy of shanghai in China

2021 ◽  
Author(s):  
chun yang ◽  
Jing Wu ◽  
Sheng Ge ◽  
Wenguang Sun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Vitamin D Status

Abstract Background This study was to assess vitamin D nutritional status and risk factors among pregnancy of shanghai in China. Methods A cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. All pregnancy was measured for plasma vitamin D, total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL) or very-low-density lipoprotein (VLDL) cholesterol and triglycerides, and completed OGTTs test. Age, height, and weight variables came from their electronic medical records. Criteria for vitamin D status were: <12 ng/ml: severe deficiency; 12–19 ng/ml: deficiency; 20–29 ng/ml: insufficiency; 30–50 ng/ml: normal; and > 50 ng/ml (particularly > 60 ng/ml): possibly leading to adverse effects. Vitamin D was measured from December 2016 to April 2017. Results Our study included 953 pregnant women. The mean vitamin D level of pregnancy was 16.06 (range 10.90 to 20.60) ng/ml,and severe vitamin D deficiency was 31.79%(303); vitamin D deficiency was 40.71 %(388); vitamin D insufficiency was 25.08%(239); normal vitamin D was 2.42%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, gestational diabetes mellitus, and hyperglycemia. Conclusions It is a high prevalence of vitamin D deficiency of Chinese pregnancy in shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, gestational diabetes mellitus and hyperglycemia are risk factors for vitamin D deficiency. Public health strategies should focus on the population of pregnancy in shanghai in China.

scholarly journals Vitamin D Status in Women with Gestational Diabetes Mellitus during Pregnancy and Postpartum

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Pleskačová ◽  
Vendula Bartáková ◽  
Lukáš Pácal ◽  
Katarína Kuricová ◽  
Jana Bělobrádková ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Vitamin D Status ◽  
Early Postpartum ◽  
Pregnancy And Postpartum

Of many vitamin D extraskeletal functions, its modulatory role in insulin secretion and action is especially relevant for gestational diabetes mellitus (GDM). The aims of the present study were to determine midgestational and early postpartum vitamin D status in pregnant women with and without GDM and to describe the relationship between midgestational and postpartum vitamin D status and parallel changes of glucose tolerance. A total of 76 pregnant women (47 GDM and 29 healthy controls) were included in the study. Plasma levels of 25(OH)D were measured using an enzyme immunoassay. Vitamin D was not significantly decreased in GDM compared to controls during pregnancy; however, both groups of pregnant women exhibited high prevalence of vitamin D deficiency. Prevalence of postpartum 25(OH)D deficiency in post-GDM women remained significantly higher and their postpartum 25(OH)D levels were significantly lower compared to non-GDM counterparts. Finally, based on the oGTT repeated early postpartum persistent glucose abnormality was ascertained in 15% of post-GDM women; however, neither midgestational nor postpartum 25(OH)D levels significantly differed between subjects with GDM history and persistent postpartum glucose intolerance and those with normal glucose tolerance after delivery.

scholarly journals Vitamin D status and vitamin D deficiency risk factors among pregnancy of Shanghai in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chun Yang ◽  
Wu Jing ◽  
Sheng Ge ◽  
Wenguang Sun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

Abstract Background There is increasing awareness that vitamin D deficiency in pregnant women may be associated with several adverse effects for the mother and newborn. The risks for vitamin D deficiency are unclear. This study was to assess vitamin D nutritional status and vitamin D deficiency risk factors among pregnant women in Shanghai in China. Methods This study is a cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. A total of 953 healthy pregnant women participated, serological examinations and other variables included serum 25-hydroxyvitamin D [25(OH)D], total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol, triglycerides at the first antenatal visit (12–14 weeks) pregnancy parity and age, body mass index (BMI) before pregnancy, and completed OGTTs test. Associations between vitamin D deficiency and possible predictors (age group, pre-pregnancy BMI, parity, and gestational hyperlipemia) were assessed with a multinomial logistic regression analysis. And also used to investigate the effects of 25(OH)D and the other variables on the occurrence of gestational diabetes mellitus. Results The mean vitamin D level of pregnancy was 16 (a range from 11 to 21) ng/ml, and severe vitamin D deficiency was 31.8% (303); vitamin D deficiency was 40.7% (388); vitamin D insufficiency was 25.1% (239); normal vitamin D was 2.4%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, and hyperlipemia. The increasing level of vitamin D nutritional status in pregnancy is significantly related to reducing gestational diabetes mellitus. Vitamin D deficiency is a risk factor for gestational diabetes mellitus. Conclusions It is a high prevalence of vitamin D deficiency in Chinese pregnancy in Shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, and hyperlipemia are risk factors for vitamin D deficiency. Vitamin D deficiency is a risk factor for gestational diabetes mellitus. Public health strategies to prevent vitamin D deficiency should focus on those risks to promote health pregnancy of Shanghai in China.

scholarly journals Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

2021 ◽  
Author(s):  
Kristin S. Magnusdottir ◽  
Ellen A. Tryggvadottir ◽  
Ola K. Magnusdottir ◽  
Laufey Hrolfsdottir ◽  
Thorhallur I. Halldorsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25Ohd Concentration

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.

scholarly journals Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Qiang Wei ◽  
Xiaomin Pu ◽  
Li Zhang ◽  
Yi Xu ◽  
Meifan Duan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Body Mass Index ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Mrna Levels ◽  
Gestational Week

Introduction. The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). Methods. Placental tissues from pregnant women with GDM (n=17) and normal healthy pregnant women (n=16) were collected at delivery. The expression of DUSP9 mRNA in placental tissue was analyzed by real-time PCR, while the expression of DUPS9 protein was evaluated by immunohistochemistry and western blot. Differences in the expression levels of DUSP9 mRNA and protein between the two groups were assessed, as well as potential correlations between DUSP9 mRNA expression levels and relevant clinical indicators. Results. Blood glucose levels were significantly higher in the GDM group than in the control group, based on an oral glucose tolerance test. DUSP9 protein was expressed in the placental cytotrophoblasts in both groups, and placental levels of DUSP9 protein and mRNA were significantly higher in women with GDM. Placental DUSP9 mRNA levels in all 33 women correlated moderately with delivery gestational week (R=0.465, P=0.006), fasting plasma glucose (R=0.350, P=0.046), 1-hour postload plasma glucose (R=0.363, P = 0.038), and 2-hour postload plasma glucose (R=0.366, P=0.036), but not with maternal age, preconception body mass index, prenatal body mass index, or neonatal birth weight. Multiple linear regression analysis indicated that delivery gestational week was an influence factor of DUSP9 mRNA levels (β1=0.026, P<0.05). Conclusions. DUSP9 upregulation in the placenta of GDM pregnant women may promote insulin resistance, which may correlate with the occurrence of GDM. But there is still possibility that DUSP9 upregulation was the results of insulin resistance and/or hyperglycemia. Further research is needed to explore the role of DUSP9 in GDM.

Study of vitamin D receptor gene methylation and the risk of gestational diabetes mellitus in Iranian pregnant women

Gene Reports ◽  
2021 ◽  
Vol 22 ◽  
pp. 100978
Author(s):  
Pooneh Mokarram ◽  
Golzar Rahmannezhad ◽  
Mehran Erfani ◽  
Mohammad Reza Rezvanfar ◽  
Farideh Jalali Mashayekhi
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation

scholarly journals Vitamin D and Insulin resistance in gestational diabetes mellitus

2017 ◽  
Vol 8 (3) ◽  
pp. 17-25
Author(s):  
M. Gashlan Hana ◽  
F. H. Noureldeen Amani ◽  
A. Elsherif Hanaa ◽  
Tareq Ohood
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus
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