Maternal mood disorders and lithium exposure in utero were not associated with poor cognitive development during childhood

2017 ◽  
Vol 107 (8) ◽  
pp. 1379-1388 ◽  
Author(s):  
L Forsberg ◽  
M Adler ◽  
I Römer Ek ◽  
M Ljungdahl ◽  
L Navér ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Mood Disorders ◽  
In Utero ◽  
Maternal Mood

In utero exposure to fluoride through drinking water and cognitive development delay in children

2016 ◽  
Vol 259 ◽  
pp. S206
Author(s):  
L. Valdez-Jiménez ◽  
O.D. López-Guzmán ◽  
M. Cervantes-Flores ◽  
R. Costilla-Salazar ◽  
J. Calderón-Hernández ◽  
...  
Keyword(s):  
Drinking Water ◽  
Cognitive Development ◽  
In Utero ◽  
In Utero Exposure ◽  
Development Delay

In utero exposure to fluoride and cognitive development delay in infants

2017 ◽  
Vol 59 ◽  
pp. 65-70 ◽  
Author(s):  
L. Valdez Jiménez ◽  
O.D. López Guzmán ◽  
M. Cervantes Flores ◽  
R. Costilla-Salazar ◽  
J. Calderón Hernández ◽  
...  
Keyword(s):  
Cognitive Development ◽  
In Utero ◽  
In Utero Exposure ◽  
Development Delay

scholarly journals MAGDALENA: study protocol of a randomised, placebo-controlled trial on cognitive development at 2 years of age in children exposed to SSRI in utero

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e023281 ◽  
Author(s):  
Essi Heinonen ◽  
Barbara Szymanska-von Schultz ◽  
Viktor Kaldo ◽  
Josefine Nasiell ◽  
Ewa Andersson ◽  
...  
Keyword(s):  
Cognitive Development ◽  
Pregnant Women ◽  
Maternal Depression ◽  
Statistical Power ◽  
Controlled Trial ◽  
Randomised Trial ◽  
In Utero ◽  
Primary Objective ◽  
Ethical Review ◽  
Moderate Depression

IntroductionTen per cent of all pregnant women are depressed. Standard therapy of pregnant women with moderate depression is selective serotonin reuptakeinhibitors (SSRI). Observational studies on neurodevelopment after fetal SSRI exposure show conflicting results. Our primary objective is to compare the cognitive development in children exposed to sertraline and maternal depression with those exposed to maternal depression and placebo in utero. We hypothesise that there is a significant neurodevelopmental difference between the groups. As a secondary objective, we study the add-on effect of sertraline to internet-based cognitive behavioural therapy (ICBT) to treat moderate depression during pregnancy.Methods and analysisMAGDALENA is a randomised, placebo-controlled, double-blinded trial in Stockholm Healthcare Region with 2.3 million inhabitants. The women are recruited in weeks 9–21 of pregnancy either through Antenatal Health Clinics or through social media. They are to be diagnosed with moderate depression without ongoing antidepressive therapy or any serious comorbidity. The women in the intervention arm receive sertraline combined with a 12-week period of ICBT; the control arm is treated with placebo and ICBT. We assess the cognitive development in the offspring at the age of 2 years using Bayley Scales of Infant and Toddler Development, third edition (BSID-III). We aim at recruiting 200 women, 100 women in each treatment arm, to ensure statistical power to detect a clinically relevant difference between the groups.Ethics and disseminationThis randomised trial will provide long-sought evidence about the effects of SSRI and maternal depression during pregnancy on the neurodevelopment in the offspring. The study is approved by the Regional Ethical Review Board at Karolinska Institutet in Stockholm and the Swedish Medical Products Agency. It is registered with the European Clinical Trials Database (EudraCT), Number: 2013-004444-31. Results will be disseminated at scientific conferences, published in peer-reviewed journals and made available to the public.Trial registration numberEudraCT2013-004444-31; Pre-results.

In utero pyrethroid pesticide exposure and child cognitive development from 6 to 36 months in the MARBLES longitudinal cohort

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Jacqueline Barkoski* ◽  
Deborah Bennett ◽  
Daniel Tancredi ◽  
Dana Barr ◽  
Irva Hertz-Picciotto
Keyword(s):  
Cognitive Development ◽  
Pesticide Exposure ◽  
In Utero ◽  
Longitudinal Cohort ◽  
Pyrethroid Pesticide ◽  
Child Cognitive Development

scholarly journals The roles of DNA methylation ofNR3C1 and11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior

Epigenetics ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. 1321-1329 ◽  
Author(s):  
Elisabeth Conradt ◽  
Barry M Lester ◽  
Allison A Appleton ◽  
David A Armstrong ◽  
Carmen J Marsit
Keyword(s):  
Dna Methylation ◽  
Mood Disorder ◽  
In Utero ◽  
Maternal Mood

scholarly journals Relationship between Maternal Mood Disorders and Dietary Intake of 3-Year-Olds

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Minatsu Kobayashi ◽  
Kohei Ogawa ◽  
Naho Morisaki ◽  
Hisako Tanaka ◽  
Reiko Horikawa ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Mood Disorders ◽  
Vegetable Intake ◽  
Fruit Intake ◽  
Cross Sectional ◽  
Dietary History ◽  
Maternal Mood ◽  
Physical Measurements ◽  
Psychological Distress Scale ◽  
Distress Scale

Maternal depression affects parenting and children’s early development, but its effect on dietary intake is unknown. While husbands’ involvement in parenting and having friends to talk to may reduce childcare stress, this has not been thoroughly studied. In this study, mothers were stratified by the presence or absence of mood disorders, and the effects of support from their husbands and friends on the dietary intake of their 3-year-old children were examined. This cross-sectional analysis included 920 mother-child pairs examined at the National Center for Child Health and Development in Japan. Dietary intake was assessed using a brief dietary history questionnaire, and physical measurements were taken when the children were 3 years old. The Kessler Psychological Distress Scale was used to screen for maternal mood disorders, 3 years after delivery. The presence or absence of the husband’s assistance with housework and childcare, mental support, and friends was obtained from a self-administered questionnaire when the child was 3 years old. Differences in the children’s physical measurements, energy, and food intake with the presence or absence of support for subjects with or without mood disorders were compared. Mothers with support from husbands or friends had significantly fewer mood disorders. Support from friends and family did not affect the children’s physical development and whether or not mothers had mood disorder symptoms. However, children’s vegetable intake was higher if mothers were supported. Children of mothers with mood disorders had a significantly higher vegetable intake and fruit intake, depending on the support from friends ( P = 0.046 ,   P = 0.037 ); thus, such support may increase children’s vegetable and fruit intake. The results of this study revealed the importance of supportive friends and family regarding childcare.

In utero exposure to fluoride and cognitive development delay in children

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Diana Rocha Amador * ◽  
Liliana Valdez Jimenez ◽  
Rogelio Costilla Salazar ◽  
Jaqueline Calderón Hernandez ◽  
Dania López Guzmán
Keyword(s):  
Cognitive Development ◽  
In Utero ◽  
In Utero Exposure ◽  
Development Delay

Current prognosis in fetal ventriculomegaly

1992 ◽  
Vol 77 (4) ◽  
pp. 551-555 ◽  
Author(s):  
Gail L. Rosseau ◽  
David C. McCullough ◽  
Amy L. Joseph
Keyword(s):  
Cognitive Development ◽  
Cognitive Ability ◽  
Neonatal Death ◽  
In Utero ◽  
Shunt Insertion ◽  
Content Type ◽  
Fetal Ventriculomegaly ◽  
General Experience ◽  
Fine Print

✓ A review of 51 cases referred for evaluation of fetal ventriculomegaly revealed adequate follow-up data in 40 patients. Three of the fetuses were electively aborted and 37 were delivered. There were no cases of death in utero. Of the 37 infants who were delivered, 26 (70%) were treated with shunt placement for neonatal hydrocephalus. The reasons for nontreatment included: inaccurate diagnosis, resolution of hydrocephalus by the time of delivery, neonatal death, and parental wishes. Survival time in the 26 shunt-treated patients ranged from 5 days to 14 years (average 4.25 years); five of these patients died within the first 2 weeks of life. Among the 26 treated patients, satisfactory cognitive ability was found in 10 (38%). Of the seven surviving nontreated infants, satisfactory cognitive ability was demonstrated in six (86%). Children with myelomeningocele displayed cognitive development similar to that in patients without myelomeningocele. The findings suggest that, of patients with in utero diagnosis of ventriculomegaly, approximately one-half survive (4-year average follow-up interval) and 38% of the survivors treated with shunt insertion have normal cognitive development. No subgroup likely to benefit from in utero treatment of ventriculomegaly was identified. Associated central nervous system or systemic malformations were identified in 26 (70%) of the 37 who came to delivery. This community-acquired series, not collected from a high-risk obstetrical-perinatal service, may reflect the general experience of the neurosurgeon consulting in such cases.

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