Downregulation of the cytochrome P450 4B1 protein confers a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder

Apmis ◽  
2019 ◽  
Vol 127 (4) ◽  
pp. 170-180 ◽  
Author(s):  
Jen‐Tai Lin ◽  
Ti‐Chun Chan ◽  
Chien‐Feng Li ◽  
Steven K.H. Huan ◽  
Yu‐Feng Tian ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Prognostic Factor ◽  
Urinary Bladder ◽  
Poor Prognostic Factor ◽  
Urothelial Carcinomas ◽  
Cytochrome P450 4B1

Eosinophilic Leukemoid Reaction with Eosinophilic Tumor Tissue Infiltration as an Extermely Poor Prognostic Factor in Urinary Bladder Cancer- a Known Entity Revisited

2020 ◽  
Vol 26 (4) ◽  
pp. 2817-2819
Author(s):  
Bokka Sri Harsha ◽  
R. Manikandan ◽  
K. S. Sreerag ◽  
L. N. Dorairajan ◽  
N. G. Rajesh ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Urinary Bladder ◽  
Tumor Tissue ◽  
Urinary Bladder Cancer ◽  
Leukemoid Reaction ◽  
Poor Prognostic Factor

P0094 CSF2 overexpression as a poor prognostic factor in patients with urothelial carcinoma of the upper urinary tract and urinary bladder

2014 ◽  
Vol 50 ◽  
pp. e35-e36
Author(s):  
Y.-Y. Lee ◽  
W.-J. Wu ◽  
C.-N. Huang ◽  
C.-C. Li ◽  
H.-L. Ke ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Prognostic Factor ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Poor Prognostic Factor

P0108 Overexpression of DPP4 is a poor prognostic factor for patients with urothelial carcinoma of the upper urinary tract and urinary bladder

2014 ◽  
Vol 50 ◽  
pp. e39
Author(s):  
P-I. Liang ◽  
W-J. Wu ◽  
C-N. Huang ◽  
C-C. Li ◽  
H-L. Ke ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Prognostic Factor ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Poor Prognostic Factor

scholarly journals Combination of GP88 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Is an Independent Prognostic Factor for Bladder Cancer Patients

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1796
Author(s):  
Markus Eckstein ◽  
Verena Lieb ◽  
Rudolf Jung ◽  
Danijel Sikic ◽  
Katrin Weigelt ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Tumor Cells ◽  
Immune Cells ◽  
Potential Candidate ◽  
Poor Prognostic Factor ◽  
Risk Of Death ◽  
Increased Risk ◽  
Muscle Invasive ◽  
Disease Specific

Urothelial bladder cancer (BCa) is the ninth most commonly diagnosed cancer worldwide and accounts for approximately 3% of global cancer diagnoses. We are interested in prognostic markers that may characterize tumor cells (TCs) and immune cells (ICs) and their relationship in BCa. A potential candidate marker that meets these criteria is progranulin (GP88), which is expressed separately in TCs and ICs. We analyzed GP88 expression by immunohistochemistry (IHC) in 196 muscle-invasive BCa samples using a tissue microarray. The immunoreactive score for GP88 staining in TCs and the percentage of GP88-positive ICs was determined. An easy cutoff for the staining status of TCs (positive vs. negative) and ICs (0% vs. >0%) and, more generally, negative vs. positive GP88 staining could be applied. We detected 93 patients (47.4%) and 92 patients (46.9%) with GP88-positive TCs or ICs, respectively. The IHC results were correlated with clinicopathological and survival data. Positive GP88 staining in TCs appeared to be an independent poor prognostic factor for disease-specific survival (DSS) (RR (relative risk) = 1.74; p = 0.009) and recurrence-free survival (RFS) (RR = 1.92; p = 0.002). In contrast, negative GP88 staining in ICs was an independent negative predictor for overall survival (OS) (RR = 2.18; p < 0.001), DSS (RR = 2.84; p < 0.001) and RFS (RR = 2.91; p < 0.001) in multivariate Cox’s regression analysis. When combining GP88 staining in TCs and ICs, a specific combination of GP88-positive TCs and GP88-negative ICs was associated with a 2.54-fold increased risk of death, a 4.21-fold increased risk of disease-specific death and a 4.81-fold increased risk of recurrence compared to GP88-negative TCs and GP88-positive ICs. In summary, GP88 positivity in TCs is a negative prognostic factor for DSS and RFS. In addition, GP88 positivity can mark ICs that are associated with a good prognosis (OS, DSS and RFS). The combination of GP88 staining in TCs and ICs appears to be a significant independent prognostic biomarker in muscle-invasive BCa.

Cell-type deconvolution analysis identifies cancer-associated myofibroblast component as a poor prognostic factor in multiple cancer types

Oncogene ◽  
2021 ◽  
Author(s):  
Bingrui Li ◽  
Guangsheng Pei ◽  
Jun Yao ◽  
Qingqing Ding ◽  
Peilin Jia ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Cell Type ◽  
Multiple Cancer ◽  
Deconvolution Analysis ◽  
Poor Prognostic Factor ◽  
Cancer Types

P-607 Evaluation of two phosphorylation sites establishes Aktactivation as a poor prognostic factor for all stages of NSCLC tumors

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S278
Author(s):  
P. Dennis ◽  
J. Tsurutani ◽  
J. Fukuoka ◽  
H. Tsurutani ◽  
J. Shih ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Phosphorylation Sites ◽  
Poor Prognostic Factor

scholarly journals Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: Implications for pharmacogene therapy

2002 ◽  
Vol 9 (2) ◽  
pp. 178-188 ◽  
Author(s):  
Susanne Frank ◽  
Sabine Steffens ◽  
Ute Fischer ◽  
Aurelia Tlolko ◽  
Nikolai G Rainov ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Bystander Effect ◽  
Enzyme Gene ◽  
Cytochrome P450 4B1

scholarly journals Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance

2013 ◽  
Vol 108 (10) ◽  
pp. 2039-2044 ◽  
Author(s):  
C Palmieri ◽  
O Gojis ◽  
B Rudraraju ◽  
C Stamp-Vincent ◽  
D Wilson ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Steroid Receptor ◽  
Platinum Resistance ◽  
Epithelial Cancer ◽  
Poor Prognostic Factor ◽  
Steroid Receptor Coactivator ◽  
Ovarian Epithelial Cancer
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