A functional assessment of the impact of changing grazing management of upland grassland mosaics

2020 ◽  
Vol 23 (4) ◽  
pp. 539-550
Author(s):  
Robin J. Pakeman ◽  
Debbie A. Fielding
Angiology ◽  
2021 ◽  
pp. 000331972199617
Author(s):  
Monica Verdoia ◽  
Rocco Gioscia ◽  
Matteo Nardin ◽  
Orazio Viola ◽  
Marta Francesca Brancati ◽  
...  

Aim: Instantaneous wave-free ratio (iFR) has emerged as the strategy of choice for the assessment of intermediate coronary lesions. The impact of preprocedural β-blockers therapy on the iFR was the aim of this study. Methods: We included patients undergoing functional assessment of intermediate (40%-70%) coronary lesions in 2 centers. The iFR measurement was performed by pressure-recording guidewire and calculated at the core laboratory using the manufacturers’ dedicated software. Minimal luminal diameter, reference diameter, percent diameter stenosis, and length of the lesion were measured. Positive iFR was considered for values <0.90. Results: We included 197 patients undergoing functional evaluation of 223 coronary lesions. Patients on β-blockers (69%) had more frequently hypertension ( P = .05); previous myocardial infarction ( P = .01); therapy with clopidogrel ( P = .02), statins, and aspirin; and acute coronary syndrome at presentation ( P < .001, respectively). Mean iFR values were slightly higher in patients on β-blockers (0.94 ± 0.06 vs 0.92 ± 0.06, P = .11). The rate of positive iFR was significantly lower with β-blockers (14.9% vs 27.5%, P = .04). On multivariate analysis, β-blockers use was a predictor of the significance of coronary stenoses (odds ratio [OR] = 0.48; 95% CI = 0.23-0.98; P = .05) together with lesion length (OR = 1.04; 95% CI = 1.01-1.07; P = .007). Conclusion: Among patients undergoing iFR, preprocedural β-blockers are associated with higher absolute values and a lower rate of positive iFR.


2019 ◽  
Vol 41 (6) ◽  
pp. 535 ◽  
Author(s):  
C. M. Waters ◽  
S. E. McDonald ◽  
J. Reseigh ◽  
R. Grant ◽  
D. G. Burnside

Demonstrating sustainable land management (SLM) requires an understanding of the linkages between grazing management and environmental stewardship. Grazing management practices that incorporate strategic periods of rest are promoted internationally as best practice. However, spatial and temporal trends in unmanaged feral (goat) and native (kangaroo) populations in the southern Australian rangelands can result land managers having, at times, control over less than half the grazing pressure, precluding the ability to rest pastures. Few empirical studies have examined the impacts of total grazing pressure (TGP) on biodiversity and resource condition, while the inability to manage grazing intensity at critical times may result in negative impacts on ground cover, changes in pasture species composition, increased rates of soil loss and reduce the ability for soils to store carbon. The widespread adoption of TGP control through exclusion fencing in the southern Australian rangelands has created unprecedented opportunities to manage total grazing pressure, although there is little direct evidence that this infrastructure leads to more sustainable land management. Here we identify several key indicators that are either outcome- or activity-based that could serve as a basis for verification of the impacts of TGP management. Since TGP is the basic determinant of the impact of herbivory on vegetation it follows that the ability for rangeland pastoral management to demonstrate SLM and environmental stewardship will rely on using evidence-based indicators to support environmental social licence to operate.


2006 ◽  
Vol 24 (6) ◽  
pp. 976-982 ◽  
Author(s):  
Dominique Dubois ◽  
Ravinder Dhawan ◽  
Helgi van de Velde ◽  
Dixie Esseltine ◽  
Sanjay Gupta ◽  
...  

Purpose Bortezomib, a boronic acid dipeptide, has been recently introduced as a new approach to treating multiple myeloma (MM). The goal of this work was to evaluate the added value of patient-reported outcomes (PRO) in the interpretation of bortezomib clinical trial outcomes. Patients and Methods Two hundred two patients with relapsed, refractory MM were treated with bortezomib as part of the SUMMIT (Study of Uncontrolled Multiple Myeloma Managed with Proteasome Inhibition Therapy) study. Patients were administered the following four PRO measures at several time points: the European Organisation for Research and Treatment of Cancer (EORTC) core Quality of Life Questionnaire (QLQ-C30) and the myeloma-specific module (QLQ-MY24), the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue scale, and the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG) Neurotoxicity (Ntx) scale. Minimal important difference (MID) thresholds were used to define patients as improved, stable, or worsened. A survival analysis was conducted to assess the predictive power of PRO data. Results For the total population, there was a positive change between baseline and best end point. Consistent with the clinical responses, change in PRO scores showed statistically significant differences between response groups with PRO improvement in patients with complete response (CR) or partial response (PR), mostly stable scores in patients with minor response or no change, and deterioration in most scores for patients with progressive disease. Change in scores for neuropathy-related symptoms was reasonably stable. In contrast, fatigue scores significantly improved for patients with CR or PR. When various MID thresholds were applied, the proportion of improved patients exceeded 35% for several domains within all change group definitions. Moreover, survival analysis results demonstrated the additional prognostic information PRO data can provide to supplement clinical data. Conclusion This study demonstrated the complementary value for PRO assessments in further interpreting clinical response, the impact of adverse effects, and patient prognosis in clinical trials.


2013 ◽  
Vol 53 (8) ◽  
pp. 856 ◽  
Author(s):  
T. Coventry ◽  
H. Sutherland ◽  
M. Waters ◽  
P. Dutton ◽  
B. Gream ◽  
...  

The Cicerone Project began as a producer-led partnership that sought, over a period of 8 years, to enhance the profitability and sustainability of livestock enterprises by improving the connection between those producers, research and extension. Following a detailed survey, the research and extension needs of livestock producers were identified and several applied investigations were conducted to meet those needs and delivered through a range of extension activities. This final paper of the Cicerone Special Issue reflects on the entire Project from a wide array of perspectives, including livestock producers, researchers, extension specialists and staff employed by the Project, all of whom are authors of this paper. A notable early successful outcome of the Project was the improved precision of footrot diagnosis, which has been of value to the entire sheep industry, and that flowed from a field investigation of benign and virulent footrot combined with detailed genetic investigations, which led to an improved testing regime. This paper also reflects on the findings of an unreplicated agricultural ecosystem research trial, which measured the impact of pasture renovation, increased soil fertility and grazing management on the profitability and sustainability of three different 53-ha farmlets. Valuable findings from this whole-farmlet trial included the need for a high quality feed supply for increasing stocking rate and animal liveweights; the ability and utility of satellite imagery to detect changes in pasture growth, composition and recent grazing pressure; the value of short grazing and long rest periods for controlling Barber’s pole worms of sheep; the impact of increased stocking rates on whole-farm profitability and risk; methods of optimising decisions relating to pasture renovation, fertiliser applications and grazing management; and an integrated analysis of all key measured components of the farmlet management systems. Collectively, these findings were powerful as they were demonstrated at a scale credible to livestock producers using the ‘compare – measure – learn – adopt’ approach, which was the key philosophy adopted by the Cicerone Project. By comparing and measuring different whole-farm systems, and by ensuring that producers had ownership of the trial process, the Project successfully delivered objective findings that producers trusted and which increased our understanding of important drivers of complex grazing enterprises under variable climatic conditions. Some of these drivers included: the influence of soil phosphorus on botanical composition and subsequent livestock production, the role of pasture renovation and soil fertility on herbage supply, herbage quality and stocking rate, and the improved gastrointestinal nematode control delivered by intensive rotational grazing. The beneficiaries of the Project included the 180 farmer members who participated in some 61 field days and workshops; the research and extension collaborators including four postgraduates who completed their research investigations in conjunction with the Project; and some 500 undergraduate and 300 technical students who benefited from coming to understand the applied field comparisons of the three whole-farmlet systems. Having livestock producers play a significant leadership role led to valuable outcomes achieved with research collaborators; this should encourage the development of other learning partnerships which aim to explore complex farming system issues.


2003 ◽  
Vol 9 (4) ◽  
pp. 302 ◽  
Author(s):  
Josh Dorrough ◽  
Julian Ash

The presence of perennial plant species in grazed habitats may be an imperfect predictor of their long-term ability to persist under grazing by livestock. This is particularly the case in landscapes where grazing by livestock is a relatively recent occurrence or where management practices are leading to intensification of grazing. This paper investigates the impacts of grazing on the native perennial inter-tussock forb Leptorhynchos elongatus (Asteraceae) in grasslands on the Monaro Tablelands of New South Wales. Although the species persists in grazed habitats, exclosures indicate that current grazing management can lead to severe depletion of seed, largely due to selective removal of flowers and seed heads by livestock. A population model suggests that under current grazing management, population growth rates may be negative. Removal of livestock during flowering and seed set may assist long-term persistence of this species in grazed habitats. Despite almost 200 years of livestock grazing on the Monaro Tablelands, recent intensification of grazing management could result in the future loss of some plant species in grazed habitats.


2016 ◽  
Vol 30 (2) ◽  
pp. 110-128 ◽  
Author(s):  
Christine L. Nittrouer ◽  
Karrie A. Shogren ◽  
Julie L. Pickens

Purpose:This study examined the impact of using a collaborative process with person-centered teams and a functional assessment of problems in the workplace to design individualized goals and self-management interventions to support young adults with disabilities. These young adults had achieved employment through a customized employment process but were beginning to face challenges maintaining and advancing in their job roles.Method:A single subject, multiple baseline study was conducted with three individuals ages 22–29 years with autism and/or intellectual disability to determine the impact of the intervention on on-task behavior and job task completion.Results:The results suggest that the process can lead to meaningful change in the on-task and job completion behavior of young adults with disabilities in inclusive employment settings, although there were limitations.Conclusion:The findings, outcomes, and implications confirm and extend our understanding of the impact of person-centered teams, goal setting, functional assessment, and self-management after young adults with disabilities are employed in community-based settings.


1996 ◽  
Vol 18 (2) ◽  
pp. 194 ◽  
Author(s):  
RK Heitschmidt ◽  
JW Walker

This paper examines the ecological, economic, and social aspects of grazing management technology as it relates to sustaining rangeland ecosystems. We adopt FAO's definition of sustainable agriculture, that is, 'The management and conservation of the resource base and the orientation of technological and institutional changes in such a manner as to insure the attainment and continued satisfaction of human needs for present and future generations. Such sustainable development is environmentally non-degrading, technically appropriate, economically viable and socially acceptable." We explore the ecological aspects of grazing management as they relate to the need to balance solar energy capture and harvest efficiency so as to maximize productivity on a sustained basis. The long- term success or failure of all grazing strategies hinges around management's ability to control the frequency and severity of defoliation of individual plants over time and space. This is a particularly formidable challenge in rangeland environments because of high levels of environmental uncertainty. We then focus attention on the social aspects of grazing management. Grazing management is a social process by virtue of its human component and the major social dilemma encountered in grazed agroecosystems centers around the impacts that ever-increasing human desires have on rangeland resources. We examine the role of ecological economics and the impact of varying human value systems on management of rangeland resources. The fundamental problem encountered in the management of natural resources such as rangeland ecosystems is absence of perfect ecological knowledge. We conclude that the major social dilemma of grazing management stems largely from two phenomena: 1) supply side management tactics designed to meet ever increasing human demands; and 2) potential failure to accurately factor long-term ecological costs into present day value systems. As such, we conclude that current grazing management technology necessarily requires moderate rates of stocking be employed to insure rangeland agriculture (i.e. grazing) is ecologically sound, economically viable, and socially acceptable.


2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi201-vi201 ◽  
Author(s):  
Margaret Johnson ◽  
Luis Ramirez ◽  
James Herndon ◽  
Woody Massey ◽  
Eric Lipp ◽  
...  

Abstract OBJECTIVE There is no validated model for delivering palliative care (PC) in the glioblastoma (GBM) population. The primary objectives were to assess the feasibility and determine the acceptability of a time-based model of integrated specialty PC to patients and providers. Secondary objectives were to estimate the impact on healthcare utilization and quality of life (QoL) compared to historical controls. METHODS We consented and referred patients to PC at their initial Neuro-Oncology consultation between 4/2018 and 5/2019. We conducted QoL assessments (NCCN Distress Tool; Functional Assessment of Cancer Therapy-Brain (FACT-BR); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); Epworth Sleepiness Scale (ESS)) at (1) baseline (2) immediately after chemoradiation, and (3) 6 months following chemoradiation. Ongoing PC follow-up was at the discretion of the PC provider. We administered the Edmonton Symptom Assessment System (ESAS) before and after PC visits. We measured patient and referring provider satisfaction using FAMCARE-16 and a PC departmental survey, respectively. RESULTS We did not meet our goal enrollment of 50 patients. 32 were offered participation, 12 consented and 8 attended at least one PC visit. The mean number of PC visits was 1.6. Mean age was 62 (42–79). 75% had a KPS ≥80. Of those that did not complete the study, 2 died and 5 either withdrew consent or declined further visits. At baseline, 91.7 % had a NCCN distress score ≥4. Patients were overall satisfied with the intervention. CONCLUSION Introduction of specialty PC at the time of GBM diagnosis is challenging. Participants reported their experience as overall positive. Results from referring providers are pending. Due to low-enrollment we did not pursue further statistical comparisons regarding healthcare utilization compared to historical controls.


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