Whole-genome amplification for the detection of molecular targets and minimal residual disease monitoring in acute lymphoblastic leukaemia

A centrifugal microfluidic system for automated, highly sensitive and multiplexed qPCR analyses, demonstrated for minimal residual disease monitoring in acute lymphoblastic leukaemia.

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Applicability of droplet digital polymerase chain reaction for minimal residual disease monitoring in Philadelphia‐positive acute lymphoblastic leukaemia

Hematological Oncology ◽

10.1002/hon.2913 ◽

2021 ◽

Author(s):

Michela Ansuinelli ◽

Irene Della Starza ◽

Alessia Lauretti ◽

Loredana Elia ◽

Veronica Siravo ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Acute Lymphoblastic Leukaemia ◽

Lymphoblastic Leukaemia ◽

Residual Disease ◽

Disease Monitoring ◽

Chain Reaction ◽

Minimal Residual Disease Monitoring ◽

Polymerase Chain ◽

Digital Polymerase Chain Reaction ◽

Minimal Residual

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Faculty Opinions recommendation of Cloned IGH VDJ targets as tools for personalized minimal residual disease monitoring in mature lymphoid malignancies; a feasibility study in mantle cell lymphoma by the Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717297959.792752812 ◽

2012 ◽

Author(s):

Nicolas Mounier

Keyword(s):

Mantle Cell Lymphoma ◽

Minimal Residual Disease ◽

Feasibility Study ◽

Residual Disease ◽

Cell Lymphoma ◽

Disease Monitoring ◽

Lymphoid Malignancies ◽

Minimal Residual Disease Monitoring ◽

Mantle Cell ◽

Minimal Residual

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Faculty Opinions recommendation of Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725402243.793506131 ◽

2015 ◽

Author(s):

Jan Starý ◽

Michaela Kotrová

Keyword(s):

Acute Lymphoblastic Leukaemia ◽

Prospective Study ◽

Minimal Residual Disease ◽

Lymphoblastic Leukaemia ◽

Clinical Utility ◽

Residual Disease ◽

Childhood Acute Lymphoblastic Leukaemia ◽

A Prospective Study ◽

Minimal Residual

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Minimal residual disease monitoring via AML1-ETO breakpoint tracing in childhood acute myeloid leukemia

Translational Oncology ◽

10.1016/j.tranon.2021.101119 ◽

2021 ◽

Vol 14 (8) ◽

pp. 101119

Author(s):

Xiaoyan Chen ◽

Suyu Zong ◽

Meihui Yi ◽

Chao Liu ◽

Bingrui Wang ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Minimal Residual Disease ◽

Myeloid Leukemia ◽

Residual Disease ◽

Disease Monitoring ◽

Minimal Residual Disease Monitoring ◽

Childhood Acute Myeloid Leukemia ◽

Minimal Residual ◽

Acute Myeloid

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Implementation of a simplified flow cytometric assays for minimal residual disease monitoring in childhood acute lymphoblastic leukemia

Cytometry Part B Clinical Cytometry ◽

10.1002/cyto.b.21394 ◽

2016 ◽

Vol 94 (1) ◽

pp. 94-99 ◽

Cited By ~ 4

Author(s):

Ester Vinhas ◽

Norma Lucena-Silva ◽

Francisco Pedrosa

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Minimal Residual Disease ◽

Residual Disease ◽

Lymphoblastic Leukemia ◽

Childhood Acute Lymphoblastic Leukemia ◽

Disease Monitoring ◽

Flow Cytometric ◽

Minimal Residual Disease Monitoring ◽

Minimal Residual

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Detailed immunophenotyping of B-cell precursors in regenerating bone marrow of acute lymphoblastic leukaemia patients: implications for minimal residual disease detection

British Journal of Haematology ◽

10.1111/bjh.14682 ◽

2017 ◽

Vol 178 (2) ◽

pp. 257-266 ◽

Cited By ~ 10

Author(s):

Prisca M. J. Theunissen ◽

Lukasz Sedek ◽

Valerie De Haas ◽

Tomasz Szczepanski ◽

Alita Van Der Sluijs ◽

...

Keyword(s):

Bone Marrow ◽

Acute Lymphoblastic Leukaemia ◽

B Cell ◽

Minimal Residual Disease ◽

Lymphoblastic Leukaemia ◽

Residual Disease ◽

Disease Detection ◽

Minimal Residual Disease Detection ◽

B Cell Precursors ◽

Minimal Residual

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Is Minimal Residual Disease Monitoring Clinically Relevant in Adults with Acute Myelogenous Leukemia?

Current Hematologic Malignancy Reports ◽

10.1007/s11899-013-0157-2 ◽

2013 ◽

Vol 8 (2) ◽

pp. 109-115 ◽

Cited By ~ 7

Author(s):

Karen-Sue B. Carlson ◽

Monica L. Guzman

Keyword(s):

Minimal Residual Disease ◽

Acute Myelogenous Leukemia ◽

Residual Disease ◽

Myelogenous Leukemia ◽

Disease Monitoring ◽

Minimal Residual Disease Monitoring ◽

Acute Myelogenous ◽

Minimal Residual

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Flow cytometric minimal residual disease assessment of peripheral blood in acute lymphoblastic leukaemia patients has potential for early detection of relapsed extramedullary disease

Journal of Clinical Pathology ◽

10.1136/jclinpath-2017-204828 ◽

2018 ◽

Vol 71 (7) ◽

pp. 653-658 ◽

Cited By ~ 3

Author(s):

Alissa Keegan ◽

Karry Charest ◽

Ryan Schmidt ◽

Debra Briggs ◽

Daniel J Deangelo ◽

...

Keyword(s):

Acute Lymphoblastic Leukaemia ◽

Minimal Residual Disease ◽

Lymphoblastic Leukaemia ◽

Peripheral Blood ◽

Residual Disease ◽

Diagnostic Value ◽

Disease Assessment ◽

Extramedullary Disease ◽

Systemic Relapse ◽

Minimal Residual

ObjectivesTo evaluate peripheral blood (PB) for minimal residual disease (MRD) assessment in adults with acute lymphoblastic leukaemia (ALL).MethodsWe analysed 76 matched bone marrow (BM) aspirate and PB specimens independently for the presence of ALL MRD by six-colour flow cytometry (FC).ResultsThe overall rate of BM MRD-positivity was 24% (18/76) and PB was also MRD-positive in 22% (4/18) of BM-positive cases. We identified two cases with evidence of leukaemic cells in PB at the time of the extramedullary relapse that were interpreted as MRD-negative in BM.ConclusionsThe use of PB MRD as a non-invasive method for monitoring of systemic relapse may have added clinical and diagnostic value in patients with high risk of extramedullary disease.

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