Immature platelets as a biomarker for disease severity and mortality in COVID‐19 patients

AbstractSepsis is associated with high morbidity and mortality, and short-term mortality remains above 30% despite relevant supportive and antibiotic treatments. The aim of this systematic review was to summarize and discuss the current evidence of the association of an increased number of circulating immature platelets with disease severity and mortality in patients with sepsis or septic shock. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered at the PROSPERO database (registration number: CRD42018104326). A systematic literature search was performed in PubMed, Web of Science, Scopus, and Embase on June 20, 2018, without time restrictions. The included studies were quality-assessed by the National Institutes of Health's Quality Assessment Tools. In total, 14 studies were included. The parameters used for the determination of platelet maturity were mean platelet volume, immature platelets fraction, reticulated platelet percentage, and absolute immature platelets count. Nine studies reported significantly increased immature platelet markers in nonsurvivors of septic shock compared with survivors, as well as in patients with severe sepsis or septic shock compared with patients without severe sepsis and septic shock. Six of these nine studies demonstrated that increased immature platelet markers were predictors of mortality and/or disease severity (area under the receiver operating curve: 0.599–0.886). This review suggests that an increased number of circulating immature platelets is associated with increased disease severity and mortality in patients with sepsis and septic shock. Larger studies are needed to confirm whether immature platelets should be routinely monitored to support the prediction of disease severity and mortality in septic patients.

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Disease severity predicts bone loss: A longitudinal study in inflammatory bowel disease patients

Gastroenterology ◽

10.1016/s0016-5085(01)83124-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A628-A628

Author(s):

S HENDERSON ◽

S DHALIWAL ◽

N HOFFMAN ◽

R PRINCE

Keyword(s):

Inflammatory Bowel Disease ◽

Longitudinal Study ◽

Bone Loss ◽

Disease Severity ◽

Bowel Disease ◽

Inflammatory Bowel

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Psoriasis Lessens Quality of Life Regardless of Disease Severity

Skin & Allergy News ◽

10.1016/s0037-6337(06)71449-8 ◽

2006 ◽

Vol 37 (8) ◽

pp. 13

Author(s):

KERRI WACHTER

Keyword(s):

Quality Of Life ◽

Disease Severity

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361 The intrinsic mitochondrial oxidative capacity of human failing hearts is depressed and relates to disease severity but keeps normal regulatory properties

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90218-9 ◽

2003 ◽

Vol 2 (1) ◽

pp. 70

Author(s):

B METTAUER ◽

J ZOLL ◽

B NGUESSAN ◽

F RIBERA ◽

E LAMPERT ◽

...

Keyword(s):

Disease Severity ◽

Oxidative Capacity ◽

Mitochondrial Oxidative Capacity ◽

Regulatory Properties

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Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000667 ◽

2020 ◽

pp. 1-8

Author(s):

Jeniffer Danielle M. Dutra ◽

Quelson Coelho Lisboa ◽

Silvia Marinho Ferolla ◽

Carolina Martinelli M. L. Carvalho ◽

Camila Costa M. Mendes ◽

...

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Fatty Liver ◽

Disease Severity ◽

Fatty Liver Disease ◽

Hypovitaminosis D ◽

Alcoholic Fatty Liver ◽

Vitamin D Levels ◽

The Mean ◽

Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

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