scholarly journals Longitudinal assessment of adhesion to vascular cell adhesion molecule‐1 at steady state and during vaso‐occlusive crises in sickle cell disease

2021 ◽  
Author(s):  
Jennell White ◽  
Michael U. Callaghan ◽  
Xiufeng Gao ◽  
Ke Liu ◽  
Ahmar Zaidi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Steady State ◽  
Sickle Cell Disease ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Longitudinal Assessment ◽  
Cell Disease ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Cell Adhesion Molecule 1

C-Reactive Protein and Vascular Cell Adhesion Molecule-1 as Markers of Severity in Sickle Cell Disease

2006 ◽  
Vol 166 (3) ◽  
pp. 366 ◽  
Author(s):  
Alexandros C. Makis ◽  
Eleftheria C. Hatzimichael ◽  
Justin Stebbing ◽  
Konstantinos L. Bourantas
Keyword(s):  
Cell Adhesion ◽  
Sickle Cell Disease ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cell Disease ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Cell Adhesion Molecule 1

Expression von Vascular Cell Adhesion Molecule–1 (VCAM–1) im normalen und neoplastischen Plattenepithel des humanen Ösophagus

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
J Heidemann ◽  
C Maaser ◽  
A Lügering ◽  
TW Spahn ◽  
KP Zimmer ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1

scholarly journals Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

1994 ◽  
Vol 269 (6) ◽  
pp. 4005-4011
Author(s):  
R. Makarem ◽  
P. Newham ◽  
J.A. Askari ◽  
L.J. Green ◽  
J. Clements ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Competitive Binding ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1

scholarly journals Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1025
Author(s):  
Sara Pastorino ◽  
Sara Baldassari ◽  
Giorgia Ailuno ◽  
Guendalina Zuccari ◽  
Giuliana Drava ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Umbilical Vein ◽  
In Vitro Tests ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1 ◽  
Pet Radiopharmaceuticals

Atherosclerosis is a chronic progressive disease involving inflammatory events, such as the overexpression of adhesion molecules including the endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1). VCAM-1 is rapidly overexpressed in the first stages of atherosclerosis, thus representing a promising target for early atheroma detection. Two novel Positron Emission Tomography (PET) radiopharmaceuticals (MacroP and NAMP), based on the VCAM-1-binding peptide having sequence VHPKQHRGGSKGC, were synthesized and characterized. MacroP is derived from the direct conjugation of a DOTA derivative with the peptide, while NAMP is a biotin derivative conceived to be employed in a three-step pretargeting system, involving the use of a double-chelating derivative of DOTA. The identity of the newly synthesized radiopharmaceuticals was confirmed by mass spectrometry and, after radiolabeling with 68Ga, both showed high radiochemical purity; in vitro tests on human umbilical vein endothelial cells evidenced their VCAM-1 binding ability, with higher radioactive uptake in the case of NAMP. Moreover, NAMP might also be employed in a theranostic approach in association with functionalized biotinylated nanoparticles.

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