C-Reactive Protein and Vascular Cell Adhesion Molecule-1 as Markers of Severity in Sickle Cell Disease

2006 ◽  
Vol 166 (3) ◽  
pp. 366 ◽  
Author(s):  
Alexandros C. Makis ◽  
Eleftheria C. Hatzimichael ◽  
Justin Stebbing ◽  
Konstantinos L. Bourantas
Keyword(s):  
Cell Adhesion ◽  
Sickle Cell Disease ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cell Disease ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Cell Adhesion Molecule 1

scholarly journals Perubahan Konsentrasi Interleukin-6, C-Reactive Protein dan Soluble Vascular Cell Adhesion Molecule-1 Pada Pasien Hemodialisis dengan Dialiser Proses Ulang

2017 ◽  
Vol 3 (3) ◽  
pp. 131
Author(s):  
Pringgodigdo Nugroho ◽  
Aida Lydia ◽  
Endang Susalit
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Interleukin 6 ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Reactive Protein ◽  
Cell Adhesion Molecule 1

Pendahuluan. Penyakit kardiovaskular merupakan penyebab utama morbiditas dan mortalitas pada pasien hemodialisis (HD). Faktor risiko kardiovaskular non-tradisional yang berperan salah satunya adalah inflamasi. Penggunaan dialiser proses ulang (DPU) dilaporkan menimbulkan reaksi inflamasi yang lebih ringan dibandingkan dengan dialiser baru, tetapi belum ada data pada membran selulosa diasetat.Metode. Dua puluh pasien HD diikutsertakan pada penelitian dengan desain pre and post untuk mengetahui perubahan konsentrasi interleukin 6 (IL-6), C-reactive protein (CRP) dan soluble vascular cell adhesion molecule-1 (sVCAM-1) pasca-HD pada penggunaan DPU ke-0, ke-5, dan ke-10. Subjek penelitian adalah pasien HD kronik >3 bulan dengan membran dialiser selulosa diasetat yang diproses ulang menggunakan mesin, cairan campuran asam perasetat dan hidrogen peroksida. Urea Reduction Ratio (URR) dan delivered Kt/V dinilai pada DPU ke 0, 5 dan 10.Hasil. Konsentrasi CRP selama penelitian menurun. Median konsentrasi CRP saat DPU ke-0 adalah 3,55 mg/L, saat DPU ke-5 adalah 2,97 mg/L dan saat DPU ke-10 adalah 2,92 mg/L, dengan p=0,074. Median konsentrasi IL-6 pada DPU ke-0 adalah 9,05 pg/ml, pada DPU ke-5 adalah 10,64 pg/ml dan pada DPU ke-10 adalah 8,51 pg/ml, dengan p=0,316. Rerata konsentrasi sVCAM-1 saat DPU ke-0 adalah 3078±786 ng/ml, saat DPU ke-5 adalah 3260±836 ng/ml, saat DPU ke-10 adalah 3154±631, dengan p=0,746. Selama penggunaan DPU hingga 10 kali tidak didapatkan perubahan adekuasi HD yang dinilai dengan URR dan Kt/V.Simpulan. Pada penggunaan DPU hingga proses ulang ke-10 tidak didapatkan peningkatan respons inflamasi yang bermakna, bahkan didapatkan penurunan konsentrasi CRP walaupun secara statistik tidak bermakna.Kata Kunci: CRP, DPU, hemodialisis, IL-6, inflamasi, sVCAM-1Change of Interleukin-6, C-Reactive Protein and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Hemodialysis Patients with Reprocessed DialyzerIntroduction. Cardiovascular disease is a major cause of morbidity and mortality in hemodialysis patients. In addition to traditional cardiovascular risk factors, non-traditional cardiovascular risk factors such as inflammation were also involved. Reprocessed dialyzer has been showed to induce less inflammation than new dialyzer, but data in diacetate cellulose membrane have not been presented. Methods. Twenty hemodialysis (HD) patients were enrolled. Pre and post study design was conducted to know post dialysis concentration changes of interleukin 6 (IL-6), C-reactive protein (CRP) and soluble vascular cell adhesion molecule-1 (sVCAM-1) at reuse 0, 5 and 10. Patients were recruited if medically stable, on maintenance HD >3 months, using reprocessed diacetate cellulose membrane by automated machine with mixture of periacetic acid and hydrogen peroxide solution. Urea reduction ratio (URR) and delivered dialysis dose were used to evaluate dialysis adequacy at reuse 0, 5, and 10.Results. CRP concentration was decreased. Median concentration of CRP at reuse 0, 5 and 10 were 3.55 mg/L, 2.97 mg/L and 2.92 mg/L, p=0.074. There were no significant changes of IL-6 concentration. Median concentration of IL-6 at reuse 0, 5, and 10 were 9.05 pg/ml, 10.64 pg/ml and 8.51 pg/ml, p=0.316. Concentration of sVCAM-1 was not changed significantly, with mean sVCAM-1 concentration 3078±786 ng/ml, 3260±836 ng/ml and 3154±631 ng/ml at reuse 0, 5 and 10,p=0.746. During use of reprocessed dialyzer through 10 times, there were no significant changes of hemodialysis adequacy using URR and Kt/V.Conclusions. The use of reprocessed dialyzer through 10 times showed no significant increase in inflammatory responses. CRP concentration was decreased, although statistically not significant. Keywords: CRP, hemodialysis, IL-6, inflammation, reprocessed dialyzer, sVCAM-1  

scholarly journals Conjugated linoleic acid increased C-reactive protein in human subjects

2005 ◽  
Vol 94 (5) ◽  
pp. 791-795 ◽  
Author(s):  
Annika Smedman ◽  
Samar Basu ◽  
Stefan Jovinge ◽  
Gunilla Nordin Fredrikson ◽  
Bengt Vessby
Keyword(s):  
Cell Adhesion ◽  
Linoleic Acid ◽  
Cell Adhesion Molecule ◽  
Human Subjects ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Tnf Α ◽  
Cell Adhesion Molecule 1

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2α, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4·2g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0·003) compared with the control group. However, no changes in TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

Expression von Vascular Cell Adhesion Molecule–1 (VCAM–1) im normalen und neoplastischen Plattenepithel des humanen Ösophagus

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
J Heidemann ◽  
C Maaser ◽  
A Lügering ◽  
TW Spahn ◽  
KP Zimmer ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1
Sign in / Sign up

Export Citation Format

Share Document