scholarly journals Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

2014 ◽  
Vol 171 (9) ◽  
pp. 2300-2307 ◽  
Author(s):  
Alessandra Bitto ◽  
Domenica Altavilla ◽  
Gabriele Pizzino ◽  
Natasha Irrera ◽  
Giovanni Pallio ◽  
...  
Keyword(s):  
Inflammasome Activation ◽  
Diabetic Mice ◽  
Genetically Diabetic Mice

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Pyruvate dehydrogenase activity in cardiac mitochondria from genetically diabetic mice

Diabetes ◽  
1985 ◽  
Vol 34 (11) ◽  
pp. 1075-1081 ◽  
Author(s):  
T. H. Kuo ◽  
F. Giacomelli ◽  
J. Wiener ◽  
K. Lapanowski-Netzel
Keyword(s):  
Dehydrogenase Activity ◽  
Pyruvate Dehydrogenase ◽  
Diabetic Mice ◽  
Cardiac Mitochondria ◽  
Genetically Diabetic Mice

Defective oxidative metabolism of heart mitochondria from genetically diabetic mice

Diabetes ◽  
1983 ◽  
Vol 32 (9) ◽  
pp. 781-787 ◽  
Author(s):  
T. H. Kuo ◽  
K. H. Moore ◽  
F. Giacomelli ◽  
J. Wiener
Keyword(s):  
Oxidative Metabolism ◽  
Heart Mitochondria ◽  
Diabetic Mice ◽  
Genetically Diabetic Mice

Neuropeptide Y increases food intake in mice

1987 ◽  
Vol 253 (3) ◽  
pp. R516-R522 ◽  
Author(s):  
J. E. Morley ◽  
E. N. Hernandez ◽  
J. F. Flood
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Water Intake ◽  
Free Acid ◽  
Behavioral Analysis ◽  
Intracerebroventricular Administration ◽  
Diabetic Mice ◽  
Number Of Species ◽  
Genetically Diabetic Mice ◽  
Old Mice

Neuropeptide Y (NPY) stimulates eating in a number of species. In the studies reported here, intracerebroventricular administration of porcine NPY increased eating in mice. In the presence of food, NPY caused enhancement of water intake, whereas in the absence of food, NPY suppressed water intake. Behavioral analysis showed that NPY decreased the latency to eat, increased the time spent eating, and decreased grooming. Human NPY also increased food intake, whereas the free acid of NPY was inactive. Although some minor discrepancies in response were noted overall, NPY was as effective at stimulating food intake in genetically obese (ob/ob) mice compared with their lean littermates (ob/-), in genetically diabetic mice (db/db) and their nondiabetic heterozygote control (db/m), in streptozocin-induced diabetic mice and their controls, and in adult (8 mo old) compared with old (25 mo old) mice.

Improvement in wound healing by a novel synthetic collagen-gel dressing in genetically diabetic mice

2010 ◽  
Vol 22 (2) ◽  
pp. 61-67 ◽  
Author(s):  
Daichi Chikazu ◽  
Tetsushi Taguchi ◽  
Hiroyuki Koyama ◽  
Hisako Hikiji ◽  
Hisako Fujihara ◽  
...  
Keyword(s):  
Wound Healing ◽  
Collagen Gel ◽  
Diabetic Mice ◽  
Genetically Diabetic Mice

Transport of glucose and leucine by intestinal membrane vesicles in genetic diabetes

1980 ◽  
Vol 238 (5) ◽  
pp. G419-G423 ◽  
Author(s):  
R. Bennetts ◽  
K. Ramaswamy
Keyword(s):  
Brush Border ◽  
Brush Border Membrane ◽  
Membrane Vesicles ◽  
Diabetic Mice ◽  
Drug Induced ◽  
Intestinal Brush Border Membrane ◽  
Intestinal Brush Border ◽  
Intestinal Membrane ◽  
Small Intestinal ◽  
Genetically Diabetic Mice

Na+-dependent D-glucose and L-leucine uptakes by isolated small intestinal brush-border membrane vesicles were studied in normal and genetically diabetic mice (C57BL/KsJ-dbm). Vesicles from normal mice demonstrated transport characteristics and morphological appearances identical to those from other mammalian small intestinal brush-border membrane isolates. There was no difference found between genetically diabetic mice and their littermate controls. These data suggest that the small intestinal brush-border membrane transport is not altered in genetic diabetes in contrast to that found in drug-induced diabetes.

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