scholarly journals Angiopoietin‐like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase–phosphoinositide 3‐kinase‐dependent anti‐apoptotic signaling

2014 ◽  
Vol 105 (12) ◽  
pp. 1550-1559 ◽  
Author(s):  
Haruki Horiguchi ◽  
Motoyoshi Endo ◽  
Yuji Miyamoto ◽  
Yasuo Sakamoto ◽  
Haruki Odagiri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Spleen Tyrosine Kinase ◽  
Apoptotic Signaling ◽  
Colorectal Cancer Cells ◽  
Phosphoinositide 3 Kinase

The anti-leukemic drug nilotinib inhibits metastatic properties of colorectal cancer cells by targeting the receptor tyrosine kinase DDR1

2016 ◽  
Vol 61 ◽  
pp. S148-S149
Author(s):  
P. Tosti ◽  
C. Leroy ◽  
M. Jeitany ◽  
V. Simon ◽  
D. Bonenfant ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Colorectal Cancer Cells

scholarly journals mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism

2017 ◽  
Vol 24 (6) ◽  
pp. 1045-1062 ◽  
Author(s):  
Aikaterini Lampada ◽  
James O'Prey ◽  
Gyorgy Szabadkai ◽  
Kevin M Ryan ◽  
Daniel Hochhauser ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Colorectal Cancer Cells ◽  
Kinase Phosphorylation

The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells

2012 ◽  
Vol 75 (5) ◽  
pp. 1590-1599 ◽  
Author(s):  
Duthika M. Mallawaaratchy ◽  
Swetlana Mactier ◽  
Kimberley L. Kaufman ◽  
Katherine Blomfield ◽  
Richard I. Christopherson
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Glycolytic Enzymes ◽  
Trna Synthetases ◽  
Aminoacyl Trna Synthetases ◽  
Colorectal Cancer Cells ◽  
Phosphoinositide 3 Kinase ◽  
Ht 29

scholarly journals Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain

2007 ◽  
Vol 6 (7) ◽  
pp. 1121-1129 ◽  
Author(s):  
Ming-Hai Wang ◽  
Wei-Feng Lao ◽  
Da Wang ◽  
Yu-Lan Luo ◽  
Hang-Ping Yao
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Kinase Domain ◽  
Tyrosine Kinase Domain ◽  
Colorectal Cancer Cells ◽  
Ron Receptor

scholarly journals Adenomatous polyposis coli determines sensitivity to the EGFR tyrosine kinase inhibitor gefitinib in colorectal cancer cells

2014 ◽  
Vol 31 (4) ◽  
pp. 1811-1817 ◽  
Author(s):  
YINING ZHANG ◽  
QINGHUAN XIAO ◽  
HUIJING ZHANG ◽  
XUREN SUN ◽  
HUIJUAN GE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Kinase Inhibitor ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Egfr Tyrosine Kinase Inhibitor ◽  
Colorectal Cancer Cells

scholarly journals ENKUR Is Involved in the Regulation of Cellular Biology in Colorectal Cancer Cells via PI3K/Akt Signaling Pathway

2019 ◽  
Vol 18 ◽  
pp. 153303381984143
Author(s):  
Qing Ma ◽  
Yin Lu ◽  
Ye Gu
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Colorectal Cancer Cells ◽  
Transient Receptor ◽  
Phosphoinositide 3 Kinase

Colorectal cancer is one of the most prevalent malignancies worldwide. ENKUR is a transient receptor potential canonical–binding protein that acts as a potential regulator or effector of transient receptor potential canonical channels. It also directly interacts with the p85 regulatory subunit of phosphoinositide 3-kinase. However, the role of ENKUR in colorectal cancer remains unclear. In the present study, the expression profiles of ENKUR in the The Cancer Genome Atlas and ONCOMINE databases were analyzed. Significant downregulation of ENKUR was observed in clinical tumor samples of various cancer types, including colorectal cancer. Decreased ENKUR messenger RNA expression and ENKUR protein level were detected in 6 human colorectal cancer cell lines. Silencing of ENKUR in colorectal cancer cells led to enhanced cell proliferation, migration, and invasion, while the opposite effects were achieved in ENKUR-overexpressing cells. Furthermore, ENKUR-underexpressing cells exhibited increased activity of phosphoinositide 3-kinase /Akt signaling pathway. Downregulation of the epithelial marker, E-cadherin, and upregulation of the mesenchymal markers, vimentin and N-cadherin, were detected in ENKUR-underexpressing cells, suggesting the induction of epithelial–mesenchymal transition. In conclusion, the present study demonstrates that ENKUR may be responsible for alterations in the proliferative, migratory, and invasive potential of colorectal cancer cells through possible involvement in the phosphoinositide 3-kinase /Akt signaling pathway.

scholarly journals Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170551 ◽  
Author(s):  
Hsien-Chuen Soo ◽  
Felicia Fei-Lei Chung ◽  
Kuan-Hon Lim ◽  
Veronica Alicia Yap ◽  
Tracey D. Bradshaw ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Akt Pathway ◽  
Colorectal Cancer Cells ◽  
Phosphoinositide 3 Kinase
Sign in / Sign up

Export Citation Format

Share Document