scholarly journals Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study

2016 ◽  
Vol 107 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Naoko Sueoka‐Aragane ◽  
Nobuyuki Katakami ◽  
Miyako Satouchi ◽  
Soichiro Yokota ◽  
Keisuke Aoe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Cancer Patients ◽  
Prospective Observational Study ◽  
Plasma Dna ◽  
Lung Cancer Patients ◽  
Egfr T790m

scholarly journals A Prospective Observational Study for Monitoring Egfr T790M Using Plasma Dna in Lung Cancer Patients

2014 ◽  
Vol 25 ◽  
pp. v63
Author(s):  
Kentaro Iwanaga ◽  
Naoko Aragane ◽  
Nobuyuki Katakami ◽  
Miyako Satouchi ◽  
Soichiro Yokota ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Cancer Patients ◽  
Prospective Observational Study ◽  
Plasma Dna ◽  
Lung Cancer Patients ◽  
Egfr T790m

Latent TB infection in newly diagnosed lung cancer patients – A multicenter prospective observational study

Lung Cancer ◽  
2014 ◽  
Vol 85 (3) ◽  
pp. 472-478 ◽  
Author(s):  
Wen-Chien Fan ◽  
Wen-Ying Ting ◽  
Ming-Che Lee ◽  
Shiang-Fen Huang ◽  
Chao-Hua Chiu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Cancer Patients ◽  
Prospective Observational Study ◽  
Newly Diagnosed ◽  
Lung Cancer Patients ◽  
Latent Tb ◽  
Multicenter Prospective Observational Study ◽  
Latent Tb Infection

Distress in suspected lung cancer patients following rapid and standard diagnostic programs: a prospective observational study

2014 ◽  
Vol 24 (4) ◽  
pp. 433-441 ◽  
Author(s):  
Pepijn Brocken ◽  
Erik H. F. M. van der Heijden ◽  
Karen T. M. Oud ◽  
Gerben Bootsma ◽  
Harry J. M. Groen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Cancer Patients ◽  
Prospective Observational Study ◽  
Lung Cancer Patients

scholarly journals Dynamic changes of circulating tumour DNA in surgical lung cancer patients: protocol for a prospective observational study

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e019012 ◽  
Author(s):  
Kezhong Chen ◽  
Heng Zhao ◽  
Fan Yang ◽  
Bengang Hui ◽  
Tianyang Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Prospective Study ◽  
Cancer Patients ◽  
Prospective Observational Study ◽  
Elimination Rate ◽  
Dynamic Changes ◽  
Lung Cancer Patients ◽  
Link Type ◽  
Circulating Tumour Dna

IntroductionCirculating tumour DNA (ctDNA) has potential applications in cancer management. Most previous studies about ctDNA focused on advanced stage cancer patients. We have completed a clinical prospective study (NCT02645318) and showed the feasibility and clinical application of ctDNA detection in early stage non-small cell lung cancer (NSCLC) patients. The aim of this study is to investigate the elimination rate of ctDNA level after surgery. This is the first prospective study to evaluate the perioperative dynamic changes of ctDNA in surgical lung cancer patients.Methods and analysisThis is a prospective observational study to determine the elimination rate of circulating tumour DNA after surgery. Consecutive patients with suspected lung cancer who undergo curative-intent lung resection will be enrolled. 10 mL blood samples are taken by intravenous puncture. Plasma samples are obtained before surgery (time A) and at a series of scheduled time-points (2 min to 72 hours, time B to F) after tumour resection. DNA is prepared from 4 mL of purified plasma. A multiplex assay based on circulating single-molecule amplification and resequencing technology (cSMART) is used to simultaneously detect and quantitate hot spot EGFR, KRAS, BRAF, ERBB2, PIK3CA, TP53, ALK, RET and MET plasma DNA variants. Positive plasma mutations are validated in tumour tissue and normal lung tissue by targeted sequencing.Ethics and disseminationEthical approval has been obtained from the Peking University People’s Hospital Medical Ethics Committee (2016PHB156-01). Results will be disseminated through presentations at scientific meetings and publications in peer-reviewed journals.Trial registration numberNCT02965391; Pre-results.

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