scholarly journals Long‐term follow up of nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma

2019 ◽  
Vol 110 (6) ◽  
pp. 1995-2003 ◽  
Author(s):  
Naoya Yamazaki ◽  
Yoshio Kiyohara ◽  
Hisashi Uhara ◽  
Jiro Uehara ◽  
Yasuhiro Fujisawa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Japanese Patients ◽  
Long Term Follow Up

A randomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma.

1991 ◽  
Vol 9 (5) ◽  
pp. 736-740 ◽  
Author(s):  
L E Spitler
Keyword(s):  
Malignant Melanoma ◽  
Adjuvant Therapy ◽  
Randomized Trial ◽  
Control Groups ◽  
Disease Free Interval ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
And Control

We conducted a long-term follow-up (median, 10.5 years) of patients included in a randomized trial of levamisole versus placebo as surgical adjuvant therapy in 203 patients with malignant melanoma. Of the patients randomized, 104 received levamisole, and 99 received placebo. The results show that there is no difference between the treatment and control groups with regard to any of the three end points analyzed. These included disease-free interval, time to appearance of visceral metastasis, and survival. Moreover, there was no significant difference between the treatment and control groups after adjusting for age, sex, or stage of disease.

scholarly journals A Case of Late Delayed Metastasis of Malignant Melanoma After 27 Years After First Excision

2020 ◽  
Vol 2 (2) ◽  
pp. 1-2
Author(s):  
Claudio Bravin ◽  
◽  
Carlo Braga ◽  
Gaetana Rizzi ◽  
◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Histological Examination ◽  
Mitotic Rate ◽  
Skin Tumor ◽  
Melanocytic Lesions ◽  
Long Term Follow Up ◽  
Neoplastic Process ◽  
Abdominal Lesion

We report a case of an ultra-late delayed metastasis of malignant melanoma 27 years after the excision of the first tumor. The patient is a 67 years old Italian woman. She underwent a primary excision of a skin lesion of 1cm in diameter on the lower third of the left leg in 1984 when she was 39. According to the histological examination the lesion was a lentigo malign melanoma with an epithelial histological pattern with intra- and subepidermal diffusion. The lesion was 2.2 mm in thickness (Breslow) and was a Clark level IV melanoma; mitotic rate was 6 mitosis/mm2. No melanocytic lesions were found on excision edges and no lymph nodes were removed and examined. In March 2011, when the woman was 67 years old, an inguinal lymph node and an intraabdominal lesion were considered suspect for neoplastic process during a clinical exam of the GP. A histological examination and an eco-imaging procedure described the lesions as metastasis of malignant melanoma probably related to the first skin tumor. Within a few days she was treated with the excision of the abdominal lesion, the total greater omentectomy and the lymphadenectomy of the left inguinal region. Histological examination confirmed the suspect of metastasis of the first melanoma with a predominant epithelioid growing pattern. This case underlines the need of a long-term follow-up period for patients with melanoma.

Long-Term Follow-Up of HBeAg-Positive Young Adult Japanese Patients Treated with Corticosteroid Withdrawal Therapy for Chronic Hepatitis B

Intervirology ◽  
2006 ◽  
Vol 49 (6) ◽  
pp. 339-345
Author(s):  
Hitomi Sezaki ◽  
Fumitaka Suzuki ◽  
Tetsuya Hosaka ◽  
Norio Akuta ◽  
Takashi Someya ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Young Adult ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Japanese Patients ◽  
Corticosteroid Withdrawal ◽  
Long Term Follow Up ◽  
Withdrawal Therapy

scholarly journals Long-term follow-up of rivaroxaban use in Japanese patients with non-valvular atrial fibrillation

2017 ◽  
Vol 16 ◽  
pp. 12-14
Author(s):  
Makoto Suzuki ◽  
Akira Mizukami ◽  
Shunsuke Kuroda ◽  
Maki Ohno ◽  
Ryota Iwatsuka ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Japanese Patients ◽  
Long Term Follow Up
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