scholarly journals Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy

2017 ◽  
Vol 191 (3) ◽  
pp. 255-267 ◽  
Author(s):  
A. Schlüter ◽  
M. Horstmann ◽  
S. Diaz-Cano ◽  
S. Plöhn ◽  
K. Stähr ◽  
...  
Keyword(s):  
Murine Model ◽  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Genetic Immunization ◽  
Autoimmune Thyroid ◽  
Self Tolerance ◽  
Graves Orbitopathy

The Antibody Response in Human Autoimmune Thyroid Disease

1997 ◽  
Vol 92 (6) ◽  
pp. 529-541 ◽  
Author(s):  
Richard S. McIntosh ◽  
M. Suhail Asghar ◽  
Anthony P. Weetman
Keyword(s):  
Antibody Response ◽  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid ◽  
Thyroid Autoantigens ◽  
Reactive Antibody ◽  
Stimulating Hormone

1. The analysis of the antibody response in autoimmune thyroid disease has followed several historical trends. It was the investigation of thyroid-reactive antibody that allowed the initial characterization of the three principle thyroid autoantigens, thyroglobulin, thyroid peroxidase and the thyroid stimulating hormone receptor. 2. Analysis can be grouped under two broad areas: analysis of the physiological and pathological effects of the antibody, and analysis of the structure of the antibodies themselves. This review will focus on the latter. 3. Within recent years there has been a great increase in knowledge of thyroid-reactive antibody structure, principally through the adoption of phage display combinatorial library methodologies. While this latter technique has established some general principles for antibodies to thyroglobin and especially thyroid peroxidase, there is still a substantial gap in our knowledge of the antibody response to the thyroid stimulating hormone receptor. 4. Thyroid peroxidase antibodies have a relatively restricted V-region usage, and there is a correlation between the V-regions used and the epitope on thyroid peroxidase bound. In particular the Vκ light chain, Vκl(O12), is associated with reactivity to one epitope. 5. The purpose of this review is to bring together the latest results concerning the molecular analysis of the antibody response in autoimmune thyroid disease, to highlight areas of ignorance and conflict, and to discuss the methods adopted to circumvent the problems associated with analysis of the antibody response.

scholarly journals Incidental Identification of a Thyroid Hormone Receptor Beta (THRB) Gene Variant in a Family with Autoimmune Thyroid Disease

Thyroid ◽  
2013 ◽  
Vol 23 (12) ◽  
pp. 1638-1643 ◽  
Author(s):  
Cæcilie C. Larsen ◽  
Alexandra Dumitrescu ◽  
Laura M. Guerra-Argüero ◽  
Cecillia Gállego-Suárez ◽  
Alberto Vazquez-Mellado ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Hormone Receptor ◽  
Gene Variant ◽  
Autoimmune Thyroid ◽  
Receptor Beta

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Predictive scores in autoimmune thyroid disease: are they useful?

2019 ◽  
Vol 181 (3) ◽  
pp. R119-R131 ◽  
Author(s):  
Grigoris Effraimidis
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Prediction Models ◽  
Prediction Score ◽  
Predictive Score ◽  
Antithyroid Drugs ◽  
Newly Diagnosed ◽  
Endocrine Disease ◽  
Autoimmune Thyroid ◽  
Graves Orbitopathy

Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been introduced: The Thyroid Hormones Event Amsterdam (THEA) score: a predictive score of the development of overt AITD, the Graves’ Events After Therapy (GREAT) score: a prediction score for the risk of recurrence after antithyroid drugs withdrawal and the Prediction Graves’ Orbitopathy (PREDIGO) score: a prediction score for the development of Graves’ orbitopathy in newly diagnosed patients with Graves’ hyperthyroidism. Their construction, clinical applicability, the possible preventative measurements which can be taken to diminish the risks and the potential future developments which can improve the accuracy of the predictive scores are discussed in this review.

scholarly journals Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease

2017 ◽  
Vol 189 (3) ◽  
pp. 304-309 ◽  
Author(s):  
T. Diana ◽  
J. Krause ◽  
P. D. Olivo ◽  
J. König ◽  
M. Kanitz ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Hormone Receptor ◽  
Clinical Relevance ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Stimulating Hormone ◽  
Receptor Blocking ◽  
Autoimmune Thyroid ◽  
Blocking Antibodies ◽  
Stimulating Hormone

scholarly journals New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland

2016 ◽  
Vol 197 (6) ◽  
pp. 2119-2130 ◽  
Author(s):  
Timothy Daniel Kayes ◽  
Gary A. Weisman ◽  
Jean M. Camden ◽  
Lucas T. Woods ◽  
Cole Bredehoeft ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Murine Model ◽  
Thyroid Disease ◽  
Early Onset ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Autoimmune Exocrinopathy

Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease.

Endocrinology ◽  
1995 ◽  
Vol 136 (8) ◽  
pp. 3611-3618 ◽  
Author(s):  
L M Green ◽  
J P Lazarus ◽  
M LaBue ◽  
M M Shah
Keyword(s):  
Murine Model ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Cell Communication ◽  
Autoimmune Thyroid ◽  
Cell Cell

scholarly journals Asymmetric Graves’ Orbitopathy

2020 ◽  
Vol 11 ◽  
Author(s):  
Grigorios Panagiotou ◽  
Petros Perros
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Severe Disease ◽  
Significant Proportion ◽  
Older Age ◽  
Psychological Burden ◽  
Autoimmune Thyroid ◽  
Bilateral Disease ◽  
Graves Orbitopathy ◽  
Male Sex

Graves’ Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. Older age, male sex, active and severe disease correlate with asymmetric disease. However, the exact mechanisms causing asymmetry remain elusive. Herein, we review the literature on asymmetric GO and highlight its differences compared with bilateral GO.

scholarly journals Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population

2012 ◽  
Vol 59 (8) ◽  
pp. 717-723 ◽  
Author(s):  
Lin Liu ◽  
Hu-qun Wu ◽  
Qiong Wang ◽  
Yuan-feng Zhu ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Hormone Receptor ◽  
Autoimmune Thyroid Disease ◽  
Receptor Gene ◽  
Thyroid Stimulating Hormone ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Autoimmune Thyroid ◽  
Hormone Receptor Gene

Besondere Manifestationsformen der Autoimmunthyreopathie

Praxis ◽  
2002 ◽  
Vol 91 (27) ◽  
pp. 1151-1160
Author(s):  
Fajfr ◽  
Müller
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Chromosome 6 ◽  
Autoimmune Thyroid

Les maladies thyroïdiennes auto-immunes ou immunes (autoimmune thyroid disease, AITD) sont relativement fréquentes. Le terme de AITD comprend les thyréodites euthyroidiennes ou hypothyroïdiennes de Hashimoto avec ou sans goitre, les hyperthyroïdies classiques de Basedow et leurs variantes nettement plus rares euthyroïdiennes ou hypothyroïdiennes. Aucune des nombreuses classifications des AITD n'a pu s'imposer sur le plan international. La pathogénèse de toutes les formes d'AITD comprend une perturbation de la tolérance immune chez les individus prédisposés génétiquement (séquence HLA-DQAI*0501 sur le bras court du chromosome 6) qui provoque un processus auto-immun contre la glande thyroïdienne. Ces processus sont soit destructeurs ou inhibiteurs, soit stimulateurs, ce qui permet d'expliquer les formes très différentes de AITD. Dans de cas rares, ces processus peuvent se contrebalancer («balance hypotheseis»). Les anticorps anti-récepteurs TPO et TSH (TRAK) ont une place particulière dans le diagnostic des AITD. Les dosages de routine utilisent pour la mesure des TRAK des récepteurs qui ne peuvent pas différencier entre les anticorps stimulants ou bloquants contre les récepteurs TSH. C'est, entre autre pour ces raisons, que les résultats d'anticorps positifs ne sont utilisables qu'en connaissance de la clinique et / ou des paramètres de la fonction thyroïdienne. Ce travail présente quatre patients avec des formes plus complexes d'AITD et résume les connaissances actuelles.

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