scholarly journals Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy

2018 ◽  
Vol 192 (2) ◽  
pp. 151-164 ◽  
Author(s):  
Y. S. Kim ◽  
M. N. Kim ◽  
K. E. Lee ◽  
J. Y. Hong ◽  
M. S. Oh ◽  
...  
Keyword(s):  
Food Allergy ◽  
Cell Adhesion ◽  
T Cell ◽  
Adhesion Molecule ◽  
Murine Model ◽  
Cell Adhesion Molecule ◽  
T Cell Responses ◽  
Cell Responses

1101 Human Tumor Cells Inhibit T Cell Responses Through Expression of Carcinoembryonic-antigen-related Cell Adhesion Molecule-6 (CEACAM-6)

2012 ◽  
Vol 48 ◽  
pp. S265
Author(s):  
N. Khandelwal ◽  
M. Witzens-Harig ◽  
D. Hose ◽  
C. Pfirschke ◽  
A. Seckinger ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Carcinoembryonic Antigen ◽  
Tumor Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Cell Responses ◽  
Related Cell

scholarly journals Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 ◽  
Vol 271 (16) ◽  
pp. 9403-9409 ◽  
Author(s):  
Françoise Pagès ◽  
Marguerite Ragueneau ◽  
Sandrine Klasen ◽  
Michela Battifora ◽  
Dominique Couez ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3 ◽  
T Cell Adhesion

Antigen-specific T-cell responses in patients with non–IgE-mediated gastrointestinal food allergy are predominantly skewed to TH2

2013 ◽  
Vol 131 (2) ◽  
pp. 590-592.e6 ◽  
Author(s):  
Hideaki Morita ◽  
Ichiro Nomura ◽  
Kanami Orihara ◽  
Koichi Yoshida ◽  
Akira Akasawa ◽  
...  
Keyword(s):  
Food Allergy ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Ige Mediated ◽  
Gastrointestinal Food Allergy

scholarly journals Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of α4β1 (VLA4) Integrin in T-Cell Development

Blood ◽  
1997 ◽  
Vol 89 (7) ◽  
pp. 2461-2471 ◽  
Author(s):  
Daniel R. Salomon ◽  
Laura Crisa ◽  
Christopher F. Mojcik ◽  
Jennifer K. Ishii ◽  
George Klier ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
T Cell Development ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Cell Adhesion Molecule 1

Abstract T-cell development requires a series of discrete selection and activation signals delivered to maturing progenitors in the thymic cortex and medulla. We have previously shown the constitutive activity of the integrin, α4β1 (VLA4), on a unique subpopulation of immature cortical thymocytes and proposed a role for integrin-mediated adhesion in positive selection by cortical epithelium. In the present report we show that thymic epithelial cell lines express vascular cell adhesion molecule-1 (VCAM-1) a high-affinity ligand for α4β1, and that VCAM-1 mediates thymocyte binding to these lines. Immunohistochemistry and confocal microscopy show that VCAM-1 is selectively expressed in situ by thymic epithelium in the cortex and corticomedullary junction, two locations at which VCAM-1 could determine the interaction between immature thymocytes and selecting elements on epithelial cells. In parallel, we confirmed that fibronectin (FN), the alternative ligand for α4β1, is expressed predominantly in the medulla. These results suggest that VCAM-1 is an adhesive ligand in the thymic cortex for the activated form of α4β1 constitutively expressed during development by immature double positive thymocytes. The structural segregation of the alternative ligand, FN, to the medulla suggests that medullary FN may regulate the migration, development, and export of more mature thymocytes.

Abstract 1578: MTBhsp70 fusion protein targeting mesothelin augments tumor specific T cell responses and prolongs survival in a murine model of ovarian cancer

2012 ◽  
Author(s):  
Jianping Yuan ◽  
Pierre Leblanc ◽  
Satoshi Kashiwagi ◽  
Jean Nezivar ◽  
Elda Righi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
Fusion Protein ◽  
Murine Model ◽  
Protein Targeting ◽  
T Cell Responses ◽  
Cell Responses

Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection

2002 ◽  
Vol 4 (8) ◽  
pp. 805-813 ◽  
Author(s):  
Anita R. Schnapp ◽  
Christopher S. Eickhoff ◽  
Julio Scharfstein ◽  
Daniel F. Hoft
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
Murine Model ◽  
T Cell Responses ◽  
Cell Responses ◽  
Cruzi Infection
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