Quantitative relationship between liver fat content and metabolic syndrome in obese children and adolescents

2015 ◽  
Vol 83 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Hongxi Zhang ◽  
Huiping Yang ◽  
Can Lai ◽  
Xiaoqin Xu ◽  
Ke Huang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Quantitative Relationship ◽  
Fat Content ◽  
Liver Fat ◽  
Obese Children ◽  
Liver Fat Content

scholarly journals No Independent Association of Circulating Fetuin-A with Insulin Sensitivity in Young Women

2020 ◽  
Vol 52 (11) ◽  
pp. 809-814
Author(s):  
Sabrina Reif ◽  
Sarah Moschko ◽  
Christina Gar ◽  
Uta Ferrari ◽  
Nina Hesse ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Young Women ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Fetuin A ◽  
The Metabolic Syndrome ◽  
Independent Association

AbstractAnimal data link high circulating fetuin-A to low insulin sensitivity and observational studies identify the hepatokine as a marker of future incident type 2 diabetes mellitus in humans. However, a recent, well-powered Mendelian randomization study finds no causal role. We therefore tested in a deeply-phenotyped human cohort if circulating fetuin-A correlates independently with insulin sensitivity and how it relates to the metabolic syndrome and ectopic fat deposition. We analyzed data from 290 young women with and without recent gestational diabetes mellitus. We found that circulating fetuin-A correlates inversely with insulin sensitivity in univariate analyses, but that this correlation is lost after adjustment for markers of the metabolic syndrome and of fatty liver. Additionally, we investigated which fat compartment associates most strongly with circulating fetuin-A. In whole body MRI data from a subcohort of 152 women, this was liver fat content. We conclude that high circulating fetuin-A occurs as part of the metabolic syndrome in young women and associates most strongly with liver fat content. Its close link to the metabolic syndrome may also cause the inverse correlation of circulating fetuin-A with insulin sensitivity as we found no independent association.

Liver fat content investigated by magnetic resonance spectroscopy in obese children and youths included in multidisciplinary treatment

2012 ◽  
Vol 2 (1-2) ◽  
pp. 41-49 ◽  
Author(s):  
D. S. Bille ◽  
E. Chabanova ◽  
M. Gamborg ◽  
C. E. Fonvig ◽  
T. R. H. Nielsen ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Multidisciplinary Treatment ◽  
Fat Content ◽  
Liver Fat ◽  
Resonance Spectroscopy ◽  
Obese Children ◽  
Liver Fat Content

Effect of a short-term physical activity intervention on liver fat content in obese children

2018 ◽  
Vol 43 (6) ◽  
pp. 553-557
Author(s):  
Dong-Woo Kang ◽  
Ji-Hye Park ◽  
Mi Kyung Lee ◽  
YoonMyung Kim ◽  
In Deok Kong ◽  
...  
Keyword(s):  
Physical Activity ◽  
Liver Enzymes ◽  
Physical Activity Intervention ◽  
Fat Content ◽  
Liver Fat ◽  
Fasting Insulin ◽  
Obese Children ◽  
Short Term ◽  
Liver Fat Content ◽  
Intense Physical Activity

Nonalcoholic fatty liver disease is the most common chronic liver disease and can present with advanced fibrosis or nonalcoholic steatohepatitis. The purpose of this study was to investigate the effect of a 7-day intense physical activity intervention on liver fat content in children with obesity. Fifty-seven obese children (mean body mass index: 26.5 ± 3.2 kg/m2; mean age: 12.0 ± 0.8 years) participated in a 7-day physical activity program. All participants were housed together, and their food intake and energy expenditure were strictly controlled. Anthropometric measurements, abdominal computerized tomography scans, and blood analyses were conducted at baseline and post-intervention. Participants lost weight by 2.53 ± 0.85 kg on average (61.0 ± 9.8 vs. 58.5 ± 9.5 kg, p < 0.05), fat mass (16.7 ± 5.1 vs. 15.7 ± 4.9 kg, p < 0.05), and serum insulin (13.7 ± 6.7 vs. 3.5 ± 2.0 μU/mL, p < 0.05). However, liver fat content was increased, presented as liver-to-spleen ratio (LSR) where lower LSR represents higher liver fat content. The intervention increased aspartate transaminase level (29.42 ± 6.78 IU/L vs. 33.50 ± 9.60 IU/L, p < 0.001). The change in liver fat content was not associated with the change in fasting insulin and liver enzymes. Short-term intense physical activity increased liver fat content independent of change in fasting insulin level and liver enzymes. This is the first human study to report increased liver fat content after physical activity-induced rapid weight loss.

scholarly journals Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content

Nutrients ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1143 ◽  
Author(s):  
Sabina Waniek ◽  
Romina di Giuseppe ◽  
Sandra Plachta-Danielzik ◽  
Ilka Ratjen ◽  
Gunnar Jacobs ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin E ◽  
Body Fat ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content

scholarly journals MRI measurement of liver fat content predicts the metabolic syndrome

2013 ◽  
Vol 39 (4) ◽  
pp. 314-321 ◽  
Author(s):  
P.-H. Ducluzeau ◽  
J. Boursier ◽  
S. Bertrais ◽  
S. Dubois ◽  
A. Gauthier ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
The Metabolic Syndrome

Postprandial lipid and apolipoprotein responses following three consecutive meals associate with liver fat content in type 2 diabetes and the metabolic syndrome

2010 ◽  
Vol 211 (1) ◽  
pp. 308-314 ◽  
Author(s):  
Maarten E. Tushuizen ◽  
Petra J. Pouwels ◽  
Saskia Bontemps ◽  
Cees Rustemeijer ◽  
Niina Matikainen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
The Metabolic Syndrome ◽  
Postprandial Lipid

Predicting hepatic steatosis and liver fat content in obese children based on biochemical parameters and anthropometry

2014 ◽  
Vol 10 (2) ◽  
pp. 112-117 ◽  
Author(s):  
H-X. Zhang ◽  
X-Q. Xu ◽  
J-F. Fu ◽  
C. Lai ◽  
X-F. Chen
Keyword(s):  
Hepatic Steatosis ◽  
Biochemical Parameters ◽  
Fat Content ◽  
Liver Fat ◽  
Obese Children ◽  
Liver Fat Content

Diabetes Remission Clinical Trial (DiRECT)—Plasma Liver Function Tests Reflect Change in Liver Fat Content in Early Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1834-P
Author(s):  
SVIATLANA V. ZHYZHNEUSKAYA ◽  
AHMAD AL-MRABEH ◽  
CARL PETERS ◽  
ALISON C. BARNES ◽  
KIEREN G. HOLLINGSWORTH ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Liver Function ◽  
Liver Function Tests ◽  
Fat Content ◽  
Diabetes Remission ◽  
Liver Fat ◽  
Early Type ◽  
Liver Fat Content

115-LB: Oral Insulin–Induced Reduction in Liver Fat Content in T2DM Patients with Nonalcoholic Steatohepatitis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 115-LB
Author(s):  
MIRIAM KIDRON ◽  
SHARON PERLES ◽  
REEM KALOTI ◽  
RAMI GHANTOUS ◽  
SUHA F. SANDOUKA ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Fat Content ◽  
Liver Fat ◽  
Oral Insulin ◽  
Liver Fat Content
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