Effect of teriparatide treatment on endothelial function, glucose metabolism and inflammation markers in patients with postmenopausal osteoporosis

2016 ◽  
Vol 85 (4) ◽  
pp. 556-560 ◽  
Author(s):  
Ozgen Celer ◽  
Aysen Akalın ◽  
Cigdem Oztunali
Keyword(s):  
Glucose Metabolism ◽  
Endothelial Function ◽  
Postmenopausal Osteoporosis ◽  
Inflammation Markers ◽  
Teriparatide Treatment

The effect of denosumab or bisphosphonates in women with severe postmenopausal osteoporosis after completion of teriparatide treatment

2017 ◽  
Author(s):  
Tomaz Kocjan ◽  
Antonela Sabati Rajic ◽  
Mojca Jensterle Sever ◽  
Gaj Vidmar ◽  
Barbara Ostanek ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Teriparatide Treatment

scholarly journals Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Gorica G. Ristić ◽  
Vesna Subota ◽  
Dejana Stanisavljević ◽  
Danilo Vojvodić ◽  
Arsen D. Ristić ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Disease Activity ◽  
Impaired Glucose Metabolism ◽  
Inflammation Markers ◽  
C Peptide ◽  
Related Risk ◽  
The Impact

Abstract Objective To explore glucose metabolism in rheumatoid arthritis (RA) and its association with insulin resistance (IR) risk factors and disease activity indicators, including matrix metalloproteinase-3 (MMP3). Methods This single-center study included 127 non-diabetic subjects: 90 RA patients and 37 matched controls. IR-related risk factors, disease activity (DAS28-ESR/CRP), concentrations of inflammation markers, MMP3, glucose, specific insulin, and C-peptide (a marker of β-cell secretion) were determined. Homeostasis Model Assessment was used to establish insulin resistance (HOMA2-IR) and sensitivity (HOMA2-%S). Associations of HOMA2 indices with IR-related risk factors, inflammation markers, and RA activity were tested using multiple regression analyses. Results RA patients had significantly increased HOMA2-IR index than controls. In the RA group, multivariate analysis revealed DAS28-ESR, DAS28-CRP, tender joint counts, patient’s global assessment, and MMP3 level as significant positive predictors for HOMA2-IR (β = 0.206, P = 0.014; β = 0.192, P = 0.009; β = 0.121, P = 0.005; β = 0.148, P = 0.007; β = 0.075, P = 0.025, respectively), and reciprocal negative for HOMA2-%S index. According to the value of the coefficient of determination (R2), DAS28-ESR ≥ 5.1 has the largest proportion of variation in both HOMA2-IR indices. DAS28-ESR ≥ 5.1 and ESR were independent predictors for increased C-peptide concentration (β = 0.090, P = 0.022; β = 0.133, P = 0.022). Despite comparability regarding all IR-related risk factors, patients with DAS28-ESR ≥ 5.1 had higher HOMA2-IR than controls [1.7 (1.2–2.5) vs. 1.2 (0.8–1.4), P = 0.000]. There was no difference between patients with DAS28-ESR < 5.1 and controls [1.3 (0.9–1.9) vs. 1.2 (0.8–1.4), P = 0.375]. Conclusions RA activity is an independent risk factor for impaired glucose metabolism. DAS28-ESR ≥ 5.1 was the main contributor to this metabolic disturbance, followed by MMP3 concentration, outweighing the impact of classic IR-related risk factors.

Abstract 112: A Pathological Role of Endothelial p53 in the Regulation of Endothelial Function and Glucose Metabolism

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Masataka YOKOYAMA ◽  
Yoshio KOBAYASHI ◽  
Tohru MINAMINO
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cell ◽  
Glucose Metabolism ◽  
Endothelial Function ◽  
Mitochondrial Biogenesis ◽  
Glucose Transporter ◽  
Diabetic Patients ◽  
Glucose Transporter 1 ◽  
P53 Activation

Cellular senescence is a state of irreversible growth arrest induced by various stresses such as oncogenic stimuli. This response is controlled by negative regulators of the cell cycle like the p53 tumor suppressor protein. Accumulating evidence has suggested a role of p53 activation in various age-associated conditions including atherosclerosis, heart failure and diabetes. Here we show that endothelial p53 activation plays a pathological role in the regulation of endothelial function and glucose metabolism under diabetic conditions. Endothelial expression of p53 was markedly up-regulated in a streptozotocin-induced diabetes model. Endothelial function such as acetylcholine-dependent vasodilatation was markedly impaired in this model. Although hyperglycemia was not altered, impairment of endothelial function was significantly improved in mice with endothelial cell-specific p53 deficiency. In same way, p53 was markedly activated in ischemic vessels, and endothelial p53 deficiency enhanced ischemia-induced angiogenesis. Mechanistically, endothelial p53 up-regulated the expression of PTEN that negatively regulated the Akt-eNOS pathway, and therefore disruption of p53 improved endothelial dysfunction. We also found that endothelial p53 was markedly activated, and the Akt-eNOS pathway was attenuated in a diet-induced obesity model. Disruption of endothelial p53 activation improved dietary inactivation of eNOS that up-regulated the expression of PGC-1α in skeletal muscle, thereby increasing mitochondrial biogenesis and oxygen consumption. Inhibition of endothelial p53 also improved dietary impairment of glucose transport into skeletal muscle by up-regulating endothelial expression of glucose transporter 1. Consequently, mice with endothelial cell-specific p53 deficiency fed a high-calorie diet showed improvement of insulin sensitivity and less fat accumulation compared with control littermates. These results indicate that endothelial p53 negatively regulates endothelium-dependent vasodilatation, ischemia-induced angiogenesis, and mitochondrial biogenesis by inhibiting the Akt-eNOS pathway and suggest that inhibition of endothelial p53 could be a novel therapeutic target in diabetic patients.

The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers

2017 ◽  
Vol 8 (9) ◽  
pp. 3366-3373 ◽  
Author(s):  
Evan A. J. Boon ◽  
Kevin D. Croft ◽  
Sujata Shinde ◽  
Jonathan M. Hodgson ◽  
Natalie C. Ward
Keyword(s):  
Glucose Metabolism ◽  
Endothelial Function ◽  
Vascular Function ◽  
Acute Effect ◽  
Glucose Load ◽  
Healthy Human ◽  
Human Volunteers

The consumption of coffee, as a whole beverage, may improve vascular function, although this may be due to the caffeine.

O18. Endothelial function and glucose metabolism in overweight and obese nondiabetic woman: A possible role of l-Arginine/Nitric Oxide pathway

2011 ◽  
Vol 1 (3-4) ◽  
pp. 265
Author(s):  
Elisabetta Petrella ◽  
Lucrezia Pignatti ◽  
Isabella Neri ◽  
Fabio Facchinetti
Keyword(s):  
Nitric Oxide ◽  
Glucose Metabolism ◽  
Endothelial Function ◽  
Nitric Oxide Pathway

Calcineurin inhibitor effects on glucose metabolism and endothelial function following renal transplantation

2009 ◽  
Vol 23 (4) ◽  
pp. 511-518 ◽  
Author(s):  
Anders Åsberg ◽  
Karsten Midtvedt ◽  
Monica H. Voytovich ◽  
Pål-Dag Line ◽  
Janicke Narverud ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Glucose Metabolism ◽  
Endothelial Function ◽  
Calcineurin Inhibitor
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