scholarly journals A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study

Diabetologia ◽  
2011 ◽  
Vol 54 (11) ◽  
pp. 2755-2767 ◽  
Author(s):  
V. D. F. de Mello ◽  
U. Schwab ◽  
M. Kolehmainen ◽  
W. Koenig ◽  
M. Siloaho ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Glucose Metabolism ◽  
Endothelial Function ◽  
Controlled Trial ◽  
Impaired Glucose Metabolism ◽  
Fatty Fish ◽  
Randomised Controlled

scholarly journals The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

Diabetologia ◽  
2014 ◽  
Vol 57 (5) ◽  
pp. 878-890 ◽  
Author(s):  
Yumie Takeshita ◽  
Toshinari Takamura ◽  
Masao Honda ◽  
Yuki Kita ◽  
Yoh Zen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Randomised Controlled Trial ◽  
Glucose Metabolism ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Controlled Trial ◽  
Alcoholic Fatty Liver ◽  
Randomised Controlled ◽  
Alcoholic Fatty Liver Disease

Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial

2015 ◽  
Vol 167 ◽  
pp. 30-35 ◽  
Author(s):  
Rosa-M. Valls ◽  
Marta Farràs ◽  
Manuel Suárez ◽  
Sara Fernández-Castillejo ◽  
Montserrat Fitó ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Randomised Controlled Trial ◽  
Endothelial Function ◽  
Olive Oil ◽  
Controlled Trial ◽  
Hypertensive Patients ◽  
Randomised Controlled

scholarly journals Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial

2021 ◽  
Vol 12 ◽  
pp. 204201882110121
Author(s):  
Ada S. Cheung ◽  
Rudolf Hoermann ◽  
Jasmine Zhu ◽  
Daryl Lim Joon ◽  
Jeffrey D. Zajac ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Insulin Resistance ◽  
Single Dose ◽  
Zoledronic Acid ◽  
Randomised Controlled Trial ◽  
Glucose Metabolism ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Matsuda Index ◽  
Randomised Controlled

Background: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular testosterone production. Human studies have been conflicting. Men undergoing androgen deprivation therapy (ADT) for prostate cancer experience profound hypogonadism resulting in increased insulin resistance. In a randomised controlled trial (RCT) of zoledronic acid versus placebo in men commencing extended-duration ADT, we aimed to examine the effects on fat mass and glucose metabolism. We hypothesised that zoledronic acid, which reduces osteocalcin concentrations, would worsen ADT-induced insulin resistance. Methods: This was a prespecified secondary analysis of an RCT designed to evaluate the effects of zoledronic acid on bone microarchitecture in 76 men with non-metastatic prostate cancer undergoing curative radiotherapy combined with adjuvant ADT ( n = 39 randomised to a single dose of zoledronic acid 5 mg, n = 37 randomised to matching placebo). Oral glucose tolerance tests to determine Matsuda Index were performed at 0, 3, 12 and 24 months. Using a mixed model, mean adjusted differences [MAD (95% confidence interval)] between the groups over time are reported. Results: Over 24 months of ADT, fat mass increased and lean mass decreased for both groups, with no significant between group difference [MAD 401 g (−1307; 2103), p = 0.23 and −184 g (−1325; 955), p = 0.36 respectively]. Bone remodelling markers C-telopeptide [MAD −176 ng/l (−275; −76), p < 0.001 and P1NP −18 mg/l (−32; −5), p < 0.001] as a surrogate for osteocalcin, remained significantly lower in the zoledronic acid group, compared with placebo. There was no mean adjusted between-group difference for homeostatic model assessment 2 insulin resistance (HOMA2-IR) [−0.2 (−0.6; 0.2), p = 0.45], HbA1c [−0.1% (−0.3; 0.1), p = 0.64] or Matsuda Index [0.8 (−1.1; 2.7), p = 0.38]. The Matsuda Index decreased in both groups consistent with worsening insulin resistance with ADT. Conclusion: A single dose of zoledronic acid does not appear to influence glucose metabolism in men newly commencing ADT. Further study to evaluate the endocrine relationship between bisphosphonates, bone and glucose metabolism is required. Trial Registration Number: [ClinicalTrials.gov identifier: NCT01006395].

scholarly journals Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

2018 ◽  
Vol 32 (2) ◽  
pp. 185-197 ◽  
Author(s):  
M. M. Papamichael ◽  
Ch. Katsardis ◽  
K. Lambert ◽  
D. Tsoukalas ◽  
M. Koutsilieris ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Mediterranean Diet ◽  
Controlled Trial ◽  
Fatty Fish ◽  
Paediatric Asthma ◽  
Randomised Controlled
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