Thyrotrophin levels and coronary artery calcification: Cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2017 ◽  
Vol 87 (5) ◽  
pp. 597-604 ◽  
Author(s):  
Érique José F. Peixoto de Miranda ◽  
Márcio Sommer Bittencourt ◽  
Henrique Lane Staniak ◽  
Alexandre C. Pereira ◽  
Murilo Foppa ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Adult Health ◽  
Cross Sectional

scholarly journals Composite acute phase glycoproteins with coronary artery calcification depends on metabolic syndrome presence – The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2019 ◽  
Vol 73 (5) ◽  
pp. 408-415 ◽  
Author(s):  
Paulo H. Harada ◽  
Isabela M. Benseñor ◽  
Márcio S. Bittencourt ◽  
Khurram Nasir ◽  
Michael J. Blaha ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Longitudinal Study ◽  
Coronary Artery ◽  
Acute Phase ◽  
Coronary Artery Calcification ◽  
Adult Health

scholarly journals Chronic kidney disease and coronary artery calcification in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2017 ◽  
Vol 40 (12) ◽  
pp. 1309-1315 ◽  
Author(s):  
Cheng Suh-Chiou ◽  
Rosa M. Moysés ◽  
Marcio S. Bittencourt ◽  
Isabela M. Bensenor ◽  
Paulo A. Lotufo
Keyword(s):  
Chronic Kidney Disease ◽  
Longitudinal Study ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Coronary Artery Calcification ◽  
Adult Health

Sport specific incidence and progression of coronary artery calcification among amateur athletes: a follow-up of the Measuring Athletes Risk of Cardiovascular events (MARC) study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V Aengevaeren ◽  
A Mosterd ◽  
T.L Braber ◽  
H.M Nathoe ◽  
T.M.H Eijsvogels ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Cardiovascular Events ◽  
Coronary Atherosclerosis ◽  
Sport Performance ◽  
Funding Source ◽  
Cross Sectional ◽  
Amateur Athletes ◽  
Entire Cohort

Abstract Background Emerging evidence indicates increased coronary atherosclerosis in amateur athletes. However, previous studies were limited by its cross-sectional design and limited sample size, preventing the exploration of sport specific associations with coronary atherosclerosis. Purpose We aimed to compare the incidence and progression of coronary artery calcification (CAC) between runners, cyclists and other types of athletes using a prospective cohort study with repetitive measurements. Methods Asymptomatic middle-aged men, who previously underwent a sports medical evaluation without abnormalities, were recruited in the Measuring Athlete's Risk of Cardiovascular events (MARC) study (n=318) and were asked to participate in this follow-up study. CT imaging was performed to assess CAC scores. Data was collected between 2012–2014 (i.e. baseline) and 2019–2020 (i.e. follow-up). We categorized participants as runners, cyclists or “other” sports (e.g. water polo, tennis, hockey, etc.) based on their dominant sport performance at baseline. Results We included 260 men in this interim analysis, with an average follow-up time of 6.3±0.5 years. Age (61.4±6.4 years), systolic blood pressure (143±20 mmHg), BMI (25.2±2.8 kg/m2), LDL-cholesterol (3.2±0.9 mmol/L), smoking (0.3 [0–8] pack years) and family history of coronary heart disease (28%) did not differ between runners (n=64), cyclists (n=75) and other athletes (n=121, all p>0.05). CAC was present in 137 (53%) men at baseline, which increased to 181 (70%) at follow-up. CAC scores increased from 1 [0–33] to 33 [0–129]. Cyclists had a lower CAC prevalence and CAC scores compared to individuals performing other sports at follow-up (Figure 1). Of those without CAC at baseline (n=123, 47%), cyclists less often developed CAC during follow-up compared with runners (adjusted OR=0.36 [0.17–0.79], p=0.01). In the entire cohort, CAC progression (ln delta CAC+1) was less prominent in cyclists than runners (adjusted B=−0.75 [−1.39 to −0.11], p=0.02), whereas progression of CAC in participants performing other sports did not differ from the runners. In participants with CAC at baseline, cyclists also had less CAC progression than runners (B=−0.49 [−0.95 to −0.02], p=0.04). Conclusion Cyclists have a lower incidence and less progression of CAC during 6 years of follow-up compared with runners and individuals performing other sports. Figure 1. Sport specific CAC prevalence and scores Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Hartstichting

scholarly journals Thyroid Function and High-Sensitivity C-Reactive Protein in Cross-Sectional Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Effect of Adiposity and Insulin Resistance

2016 ◽  
Vol 5 (4) ◽  
pp. 240-246 ◽  
Author(s):  
Érique José F. Peixoto de Miranda ◽  
Márcio Sommer Bittencourt ◽  
Itamar S. Santos ◽  
Paulo A. Lotufo ◽  
Isabela M. Benseñor
Keyword(s):  
Insulin Resistance ◽  
Longitudinal Study ◽  
Thyroid Function ◽  
High Sensitivity ◽  
Adult Health ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

Thyrotropin levels are associated with chronic kidney disease among healthy subjects in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

2017 ◽  
Vol 21 (6) ◽  
pp. 1035-1043 ◽  
Author(s):  
Érique José F. Peixoto de Miranda ◽  
Márcio Sommer Bittencourt ◽  
Alessandra C. Goulart ◽  
Itamar S. Santos ◽  
Silvia Maria de Oliveira Titan ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Longitudinal Study ◽  
Kidney Disease ◽  
Healthy Subjects ◽  
Adult Health ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Predicting cardiometabolic disturbances from waist-to-height ratio: findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline

2018 ◽  
Vol 21 (6) ◽  
pp. 1028-1035 ◽  
Author(s):  
Marcelo Castanheira ◽  
Dóra Chor ◽  
José Uéleres Braga ◽  
Letícia de Oliveira Cardoso ◽  
Rosane Härter Griep ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
False Negative ◽  
False Negative Rate ◽  
Cross Sectional Study ◽  
Discriminatory Power ◽  
Adult Health ◽  
Height Ratio ◽  
Cross Sectional ◽  
Waist To Height Ratio ◽  
Better Than

AbstractObjectiveTo evaluate the performance of waist-to-height ratio (WHtR) in predicting cardiometabolic outcomes and compare cut-off points for Brazilian adults.DesignCross-sectional study. WHtR areas under the curve (AUC) were compared with those for BMI, waist circumference (WC) and waist-to-hip ratio (WHR). The outcomes of interest were hypertension, diabetes, hypertriacylglycerolaemia and presence of at least two components of metabolic syndrome (≥2 MetS). Cut-offs for WHtR were compared and validity measures were estimated for each point.SettingTeaching and research institutions in six Brazilian state capitals, 2008–2010.SubjectsWomen (n 5026) and men (n 4238) aged 35–54 years who participated in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) at baseline.ResultsWHtR age-adjusted AUC ranged from 0·68 to 0·72 in men and 0·69 to 0·75 in women, with smaller AUC for hypertriacylglycerolaemia and the largest for ≥2 MetS. WHtR performed better than BMI for practically all outcomes; better than WHR for hypertension in both sexes; and displayed larger AUC than WC in predicting diabetes mellitus. It also offered better discriminatory power for ≥2 MetS in men; and was better than WC, but not WHR, in women. Optimal cut-off points of WHtR were 0·55 (women) and 0·54 (men), but they presented high false-negative rate compared with 0·50.ConclusionsWe recommend using WHtR (which performed similarly to, or better than, other available indices of adiposity) as an anthropometric index with good discriminatory power for cardiometabolic outcomes in Brazilian adults, indicating the already referenced limit of WHtR≥0·50.

Abstract P214: Anxiety and Depressive Symptoms are Associated with Coronary Artery Calcium. A Cross-sectional Analysis of Elsa-Brasil Baseline Data

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Itamar S Santos ◽  
Marcio S Bittencourt ◽  
Priscila T Rocco ◽  
Alexandre C Pereira ◽  
Sandhi M Barreto ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Adult Health ◽  
Older Individuals ◽  
Cross Sectional ◽  
Psychopathological Symptoms ◽  
Cross Sectional Analysis ◽  
Sectional Analysis ◽  
Age And Sex

Background: Prior mostly smaller studies of the association between symptoms of anxiety or depression and CAC have produced mixed results. Our aim was to investigate whether psychopathological symptoms and diagnoses of anxiety and depression were associated with coronary artery calcium (CAC) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Design: Cross-sectional analysis Methods: We analyzed data from 4,279 ELSA-Brasil subjects (aged 35 to 74 years) from the São Paulo site who underwent CAC score assessment and who were without previous cardiovascular disease at baseline. Prevalent CAC was defined as a CAC score above zero. Anxiety and depressive symptoms were assessed using the Clinical Interview Schedule - Revised (CIS-R). We built binary logistic regression models to determine whether CIS-R scores, anxiety or depression were associated with prevalent CAC. Results: Prevalent CAC was found in 1,211 (28.3%) individuals. After adjustment for age and sex, a direct association between CIS-R scores and prevalent CAC was revealed (odds ratio [OR]:1.12; 95% confidence interval [95%CI]:1.04-1.22). This association persisted after multivariate adjustment for other cardiovascular risk factors (OR:1.11; 95%CI: 1.02-1.20). No independent associations were found for specific diagnoses of anxiety or depression and prevalent CAC. In post-hoc models, we found a significant interaction between age, CIS-R scores, and CAC (p=0.019), suggesting a stronger association in older individuals. Conclusions: Psychopathological symptoms were directly associated with coronary atherosclerosis in the ELSA-Brasil baseline. This association was evident after adjustment for age and sex, persisted in multivariate adjusted models, and seems to be stronger in older individuals.

Abstract P295: Residential Segregation Is Associated With Uncontrolled Diabetes Among Brazilian Adults: The Brazilian Longitudinal Study Of Adult Health (elsa-brasil)

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Sharrelle Barber ◽  
Joanna Guimarães ◽  
Cardoso Leticia ◽  
Devlin Amie ◽  
Janeway Granche ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Residential Segregation ◽  
Behavioral Risk ◽  
Diabetes Diagnosis ◽  
Adult Health ◽  
Cross Sectional ◽  
Middle Income ◽  
Neighborhood Conditions ◽  
Logistic Regression Models ◽  
Uncontrolled Diabetes

Introduction: The prevalence of type-2 diabetes is increasing globally with the sharpest increases occurring in low and middle-income countries. Residential segregation results in increased exposure to adverse neighborhood environments that may inhibit the successful management of diabetes. Moreover, due to historical and contemporary forms of structural racism, marginalized racial groups are more likely to live in these environments. Using a spatial measure of neighborhood-level economic residential segregation (hereafter, segregation) we examined the association between segregation and uncontrolled diabetes in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: The sample included 828 Black, Brown/Mixed-Race, and White participants ages 35-74 with diagnosed diabetes and complete, geocoded information from the baseline examination of ELSA-Brasil (2008-2010). Residential segregation was based on data from the 2010 IBGE demographic census and calculated for study-defined neighborhoods using the local G i * statistic— a spatially weighted z-score that represents how much a neighborhood’s income composition deviates from the larger metropolitan area. Uncontrolled diabetes was based on 2017 ADA criteria and defined as HbA1c ≥ 7%. Multivariable logistic regression models were used to test cross-sectional associations between segregation and uncontrolled diabetes. Results: Black and Brown participants were more likely than Whites to live in highly segregated neighborhoods. The prevalence of uncontrolled diabetes increased across low, medium, and high levels of segregation (23.1% vs. 37.8% vs. 47.7%, respectively). In multivariable models adjusting for age, gender, race, education, income, and study site, segregation was positively associated with uncontrolled diabetes (OR: 1.20, 95% CI: 1.07-1.56). The association was attenuated but remained statistically significant in models adjusting for neighborhood characteristics, behavioral risk factors and time since diabetes diagnosis. (OR: 1.16; 95% CI: 1.05-1.28). In models that included segregation as a categorical variable, individuals living in highly segregated neighborhoods had a 2-fold higher risk of uncontrolled diabetes compared to individuals living in less segregated neighborhoods (High Segregation, OR: 2.20, 95% CI: 1.35-3.58; Medium Segregation, OR: 1.65, 95% CI: 1.08-2.51). Conclusions: Residential segregation may lead to disparate diabetes-related morbidity among urban-dwelling adults in Brazil. Moreover, the disproportionate clustering of Blacks and Browns within segregated neighborhoods implicates segregation as a potential driver of racial inequalities in these outcomes. Policies and/or structural interventions designed to improve neighborhood conditions may be viable strategies to improve the management of diabetes in this setting.

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