Investigating the potential of clinical and biochemical markers to differentiate between functional hypothalamic amenorrhoea and polycystic ovarian syndrome: a retrospective observational study

Objective: To determine the effects of Myo- inositol in young females with polycystic ovarian syndrome. Study Design and Setting: This was a quasi-experimental study and was conducted in United Medical and Dental College and Creek General Hospital from January 2017 to January 2018. Methodology: Total 100 patients were recruited based on the specific inclusion criteria of PCO diagnosed by symptoms (body mass index, menstrual irregularity, hirsutism, acne) biochemical markers (fasting insulin, random blood sugar) and ultrasound findings. Each subject in the study group was given sachet (Myo- inositol 2000mg and folic acid 400ug) once a day dissolved in glass of water for duration of 6 months. Improvement in symptoms, biochemical markers and ultrasound findings were reassessed after the completion of 6 months duration. The SPSS version 21 was used for data analysis. The paired T test was used to assess the effects of Myo-Inositol before treatment and after six months of treatment. Result: The significant relation (0.001) was observed between the intervention and PCO and its related symptoms. An evident effect was noticed in each individual after the intervention was provided to them. The relatable symptoms such as irregularities in menses, hirsutism,weight and insulin resistance were reduced by significant ratio. Conclusion: Myo – inositol has proven to be effective in reducing the PCO and its relatable symptoms in young females. Despite the limitations, enough evidence was collected that indicated a significant effect of the intervention

Download Full-text

Association of metabolic syndrome in polycystic ovarian syndrome: an observational study

The Journal of Obstetrics and Gynecology of India ◽

10.1007/s13224-011-0020-0 ◽

2011 ◽

Vol 61 (2) ◽

pp. 176-181 ◽

Cited By ~ 4

Author(s):

Ramprasad Dey ◽

Shiuli Mukherjee ◽

Ranu Roybiswas ◽

Arunima Mukhopadhyay ◽

S. C. Biswas

Keyword(s):

Metabolic Syndrome ◽

Observational Study ◽

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome

Download Full-text

Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2017.07.004 ◽

2017 ◽

Vol 11 ◽

pp. S841-S851 ◽

Cited By ~ 4

Author(s):

B.S. Nayaker ◽

Sowmya Thomas ◽

Sandhiya Ramachandran ◽

Swetha Loganathan ◽

Meenakshi Sundari ◽

...

Keyword(s):

Biochemical Markers ◽

Polycystic Ovarian Syndrome ◽

Cardiovascular Complications ◽

Ovarian Syndrome

Download Full-text

Prevalence and pattern of PCOS in women presenting with acne, a hospital based prospective observational study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20180611 ◽

2018 ◽

Vol 6 (3) ◽

pp. 899

Author(s):

Raja Shareef A. ◽

P. V. S. Prasad ◽

P. K. Kaviarasan

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Polycystic Ovarian Syndrome ◽

Acne Vulgaris ◽

Strong Association ◽

Tertiary Care ◽

Final Analysis ◽

Endocrine Disorders ◽

Medical College ◽

Ovarian Syndrome

Background: Acne is one of the most common dermatological conditions encountered in day to day practice. Many recent studies have reported a strong association between acne and underlying systemic endocrine disorders, more particularly Poly cystic ovarian syndrome. But there is scarcity of literature on the subjects in Indian population. Hence the present study was conducted with an objective of studying the association between acne and polycystic ovarian syndrome, in women presenting with adult onset acne to a tertiary care teaching hospital.Methods: A prospective observational study was carried out in department of dermatology, Dhananalakshmi Srinivasan medical college and hospital, Permabalur from January 2016 to August 2017. The study population included women above 18 years of age clinically diagnosed with acne vulgaris. The presence of polycystic ovarian syndrome was assessed using Rotterdam criteria.Results: The final analysis had included 100 women with acne. The most common type of lesion observed was comedone in 91% of women. The other most common lesions were papule seen in 73%, pustule in 35% of women. The proportion with grade I, Grade II and grade III acne was 58%, 29% and 13% respectively. The prevalence of PCOS was 30% (95% CI 21.89% to 39.58%). PCOS had shown no statistically significant association with age, marital status and regularity of menstrual cycle. The factors which have shown statistically significant association were higher BMI, presence of Hirsutism and higher waist circumference.Conclusions: PCOS is highly prevalent among women with acne. Presence of hirsutism, obesity are strong risk factors for PCOS.

Download Full-text

Effect of metformin in treating polycystic ovarian syndrome among women attending a tertiary care setting -A prospective observational study

Indian Journal of Obstetrics and Gynecology Research ◽

10.18231/j.ijogr.2021.040 ◽

2021 ◽

Vol 8 (2) ◽

pp. 188-193

Author(s):

Suresh Chandra Mondal ◽

Pinaki Sarkar

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Polycystic Ovarian Syndrome ◽

Care Setting ◽

Statistical Significance ◽

Tertiary Care ◽

Reproductive Age ◽

Significant Difference ◽

Tertiary Care Setting ◽

Ovarian Syndrome

To determine the efficacy of metformin on clinical profile and metabolic disorders in women with polycystic ovarian syndrome. Polycystic ovarian syndrome, is a heterogeneous endocrinological disorder affecting women of reproductive age and metformin was introduced to influence the pathogenesis.: A prospective observational study was conducted on 100 women with polycystic ovarian syndrome, attending department of gynaecology in a tertiary care setting and were divided into two group of 50 each. Metformin was used in 50 patients for one year. Rest 50 patients were advised about diet control and exercise. The parameters like body mass index (BMI), weight, hormonal imbalance, ovulation, and menstrual changes were analysed in both groups. Descriptive statistics for mean, SD were carried and chi-square test was used to test statistical significance using coGuide version V.1.0 and p value set at < 0.05.: The mean age was 25±10 years. Both the groups were comparable with respect to BMI and weight. There was a significant difference between the groups with respect to fasting insulin, which reduced to 7.44±1.12 from 11.97±2mIU/ml, testosterone levels reduced to 0.59±0.1 from 0.76±0.3 mIU/ml, luteinizing hormone levels reduced to 8.55±2 from 20.01±7.3 mIU/ml, and LH:FSH ratio reduced to 1.11±0.1 from 2.31±0.2 mIU/ml. In the metformin group, 22 (44%) participants were anovulation before treatment, and ovulation started in 15 (30%) after treatment which was not seen other group.Clinical, hormonal, and biochemical changes in polycystic ovarian syndrome may effectively be treated by metformin.

Download Full-text