scholarly journals Effect of metformin in treating polycystic ovarian syndrome among women attending a tertiary care setting -A prospective observational study

2021 ◽  
Vol 8 (2) ◽  
pp. 188-193
Author(s):  
Suresh Chandra Mondal ◽  
Pinaki Sarkar
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Polycystic Ovarian Syndrome ◽  
Care Setting ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Reproductive Age ◽  
Significant Difference ◽  
Tertiary Care Setting ◽  
Ovarian Syndrome

To determine the efficacy of metformin on clinical profile and metabolic disorders in women with polycystic ovarian syndrome. Polycystic ovarian syndrome, is a heterogeneous endocrinological disorder affecting women of reproductive age and metformin was introduced to influence the pathogenesis.: A prospective observational study was conducted on 100 women with polycystic ovarian syndrome, attending department of gynaecology in a tertiary care setting and were divided into two group of 50 each. Metformin was used in 50 patients for one year. Rest 50 patients were advised about diet control and exercise. The parameters like body mass index (BMI), weight, hormonal imbalance, ovulation, and menstrual changes were analysed in both groups. Descriptive statistics for mean, SD were carried and chi-square test was used to test statistical significance using coGuide version V.1.0 and p value set at < 0.05.: The mean age was 25±10 years. Both the groups were comparable with respect to BMI and weight. There was a significant difference between the groups with respect to fasting insulin, which reduced to 7.44±1.12 from 11.97±2mIU/ml, testosterone levels reduced to 0.59±0.1 from 0.76±0.3 mIU/ml, luteinizing hormone levels reduced to 8.55±2 from 20.01±7.3 mIU/ml, and LH:FSH ratio reduced to 1.11±0.1 from 2.31±0.2 mIU/ml. In the metformin group, 22 (44%) participants were anovulation before treatment, and ovulation started in 15 (30%) after treatment which was not seen other group.Clinical, hormonal, and biochemical changes in polycystic ovarian syndrome may effectively be treated by metformin.

scholarly journals Prevalence and pattern of PCOS in women presenting with acne, a hospital based prospective observational study

2018 ◽  
Vol 6 (3) ◽  
pp. 899
Author(s):  
Raja Shareef A. ◽  
P. V. S. Prasad ◽  
P. K. Kaviarasan
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Polycystic Ovarian Syndrome ◽  
Acne Vulgaris ◽  
Strong Association ◽  
Tertiary Care ◽  
Final Analysis ◽  
Endocrine Disorders ◽  
Medical College ◽  
Ovarian Syndrome

Background: Acne is one of the most common dermatological conditions encountered in day to day practice. Many recent studies have reported a strong association between acne and underlying systemic endocrine disorders, more particularly Poly cystic ovarian syndrome. But there is scarcity of literature on the subjects in Indian population. Hence the present study was conducted with an objective of studying the association between acne and polycystic ovarian syndrome, in women presenting with adult onset acne to a tertiary care teaching hospital.Methods: A prospective observational study was carried out in department of dermatology, Dhananalakshmi Srinivasan medical college and hospital, Permabalur from January 2016 to August 2017. The study population included women above 18 years of age clinically diagnosed with acne vulgaris. The presence of polycystic ovarian syndrome was assessed using Rotterdam criteria.Results: The final analysis had included 100 women with acne. The most common type of lesion observed was comedone in 91% of women. The other most common lesions were papule seen in 73%, pustule in 35% of women. The proportion with grade I, Grade II and grade III acne was 58%, 29% and 13% respectively. The prevalence of PCOS was 30% (95% CI 21.89% to 39.58%). PCOS had shown no statistically significant association with age, marital status and regularity of menstrual cycle. The factors which have shown statistically significant association were higher BMI, presence of Hirsutism and higher waist circumference.Conclusions: PCOS is highly prevalent among women with acne. Presence of hirsutism, obesity are strong risk factors for PCOS.

scholarly journals Prevalence of metabolic syndrome in women with polycystic ovarian syndrome: an observational study in a tertiary care centre in Pondicherry, India

2018 ◽  
Vol 7 (9) ◽  
pp. 3774
Author(s):  
Indu N. R. ◽  
Hiremath P. B. ◽  
Urmi Sanyal ◽  
Shilpa . ◽  
Rohini . ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Observational Study ◽  
Polycystic Ovarian Syndrome ◽  
Economic Status ◽  
Tertiary Care ◽  
Clinical History ◽  
Reproductive Age ◽  
Tertiary Care Centre ◽  
Low Hdl ◽  
Ovarian Syndrome

Background: Polycystic Ovarian Syndrome (PCOS) is a multifactorial, polygenic and multisystem endocrine disorder affecting women in reproductive age. PCOS diagnosis is based on 2003 Rotterdam criteria It has been noted that hyperinsulinemia is a central factor in the pathogenesis of PCOS. Many studies show evidence of a critical link between PCOS and Metabolic Syndrome (MBS).Methods: It was a hospital - based observational study done over a period of one year with a sample size of 177.An observational study was done in patients satisfying the inclusion and exclusion criteria. After taking informed and written consent, history was obtained from the patient to know the age, socioeconomic status, present and past clinical history, menstrual and obstetric history, personal and family history and any other history as deemed necessary. Patient was clinically assessed to know the height, weight, body mass index.Results: The prevalence of MBS was 37.2%. The commonest age group was between 25- 35 years.There is no statistical association between educational qualification, economic status and the prevalence of MBS and There no significant association between the presence of acne, androgenic aloepecia and the presence of PCOS.While the presence of increased waist circumference > 88cms, USG findings consistent with PCOS, high blood pressure > 130/85 mm of Hg, elevated FBS > 110 mg/dl, low HDL <50 mg/dl were statistically significant.Conclusions: The results can be used to formulate a screening policy for metabolic syndrome, particularly in the low resource settings of developing countries.

scholarly journals Phenotypic Variation of Insulin Resistance among Polycystic Ovarian Syndrome Patients in Semiurban North Indian Population

2021 ◽  
Author(s):  
Chaitali Maitra ◽  
Ramesh Chandra Gupta ◽  
Rishika Raj
Keyword(s):  
Insulin Resistance ◽  
Regression Analysis ◽  
Polycystic Ovarian Syndrome ◽  
Specific Treatment ◽  
Reproductive Age ◽  
Model Assessment ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ovarian Syndrome ◽  
Rotterdam Criteria

Introduction: Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in the women of reproductive age. Studies show that there is an intensive relationship between insulin and gonadal function. As per Rotterdam Criteria, there are four major phenotypes of PCOS with different presentation. Early detection of Insulin Resistance (IR) and consequential prevention of Metabolic Syndrome (MS) associated with PCOS may lead to better prospect for the disease. Aim: To find the pattern of IR in all the phenotypes of PCOS in relation to Waist Hip Ratio (WHR), Body Mass Index (BMI) and Testosterone and thereby, providing data for designing phenotype specific treatment of the disease. Materials and Methods: In this cross-sectional observational study, fasting insulin and fasting glucose were analysed to calculate Homeostasis Model Assessment (HOMA-IR) and Testosterone for total 144 female subjects of reproductive age group (18-40 years). Subjects were classified in to four groups as per Rotterdam Criteria. Complete PCOS (PCO-COM), PCO with Oligo/Anovulation (PCO-O), Anovulation with Hyperandrogenism (O-HA), and PCO with Hyperandrogenism (PCO-HA). Regression analysis was done to find the relation among the study variables. Analysis of Variance (ANOVA) was used to analyse the significant variance among the groups. Results: IR was found to be maximum among O-HA phenotype (2.4±0.37) and lowest among PCO-HA phenotypes (1.3±0.22). Regression analysis shows that there exist significant associations between IR and BMI (t=4.96, p=0.001) as well as between IR and WHR (t=2.97, p=0.003). No independent association between testosterone and IR was observed. Conclusion: Significant difference of IR, WHR, and BMI was observed among the four phenotypes of PCOS. Due to increased IR, O-HA and PCO-COM phenotypes are more predisposed to Cardiometabolic consequences of PCOS.

scholarly journals Study of clinical characteristics of women with polycystic ovarian syndrome

2020 ◽  
Vol 9 (6) ◽  
pp. 2424
Author(s):  
Jeevanthy P. Upadhya ◽  
Supriya Rai ◽  
Shrikrishna V. Acharya
Keyword(s):  
Clinical Characteristics ◽  
Acanthosis Nigricans ◽  
Polycystic Ovarian Syndrome ◽  
Tertiary Care ◽  
Vital Role ◽  
Reproductive Age ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinal disorders of the reproductive age group causing anovulation, infertility incidence being 8.7-17.8%. It is associated with obesity, insulin resistance, dyslipidaemia and metabolic syndrome. This study was aimed to study the different clinical characteristics of women diagnosed with PCOS, attending a tertiary care hospital outpatient department.Methods: This was a hospital-based cross-sectional observational study of 200 patients with PCOS meeting the revised Rotterdam criteria from January 2018-June 2019 excluding pregnant and women with other systemic disorders. A detailed history and examination done, data collected regarding menstrual complaints, features of hyperandrogenism, hirsutism, acne, oily skin and Acanthosis Nigricans (AN) was documented. All data were statistically analyzed and compared using the chi-square or fissures’ exact test. p-value <0.05 considered significant.Results: A total of 200 patients with PCOS were included in the study, of which 41% were obese, 18% lean. The mean age was 24.44±5.62 years. Menstrual complaints were present in 88% -oligomenorrhea (49%) being the most common. 59% had hirsutism,38% of severe grade. Acanthosis nigricans was present in 33% of the patients. Correlation between hirsutism and alopecia, waist to hip ratio (WHR); acanthosis and WHR were statistically significant.Conclusions: PCOS is an ill-defined symptom complex where ethnicity plays a vital role, hence creating a greater need to know the characteristics of the syndrome in different populations and ethnicity. All women presenting with oligomenorrhea or other menstrual complaint should be investigated for PCOS and treated accordingly. The syndrome usually occurs with multiple characters. Though obesity is common in PCOS, non-obese are also at risk. The prevalence of AN and Hirsutism in PCOS were comparable. This mandates a need to increase awareness regarding the syndrome in the general population.

scholarly journals A Study on the Clinical and Hormonal Profile of Polycystic Ovarian Syndrome Patients Attending a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Achala Vaidya ◽  
Sweta Yadav ◽  
Anshu Vaidya
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Care Hospital ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Hormonal Profile ◽  
Ovarian Syndrome

Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrinological disorder in women of reproductive age and has a considerable metabolic, reproductive, and cardiovascular consequences. This study was designed to provide an overview of the presentation of PCOS in the Nepalese population attending a tertiary care hospital, specifically the clinical presentation and hormonal profile. Methods: A descriptive cross-sectional study was conducted between September 14, 2019 to October 16, 2019 on patients presenting to a tertiary care hospital, after obtaining ethical clearance from Institutional Review Committee (Dated 03/09/2019) and informed consent from the patient or patient relatives. Data entry and analysis were done in Microsoft Excel 10. The data was statistically analysed using Statistical Package for the Social Sciences (SPSS) version 20.0. Results: The study included 100 PCOS patients. The mean age of the patients was 24.9 ± 4.52 years and the most common group was 26-34 years. The most common presenting symptom was menstrual irregularity which was seen in 86 (86%) of the patients, followed by weight gain in 55 (55%) of the patients. Thirty percent (30 in number) of the patients were overweight, while eleven (11%) of the patients had grade I obesity. Conclusions: PCOS has varying clinical manifestations, most commonly affecting the young women of reproductive age group. The commonest presenting complaint in the current study was menstrual abnormality. Majority of the patients had deranged hormonal profile which can lead to an increased risk of cardiovascular disease and type 2 DM. Thus, awareness regarding PCOS is important for early diagnosis and to prevent its sequalae to various complications.

Polycystic ovarian syndrome in patients with schizophrenia treated with atypical anti-psychotics: A case control study

2017 ◽  
Vol 41 (S1) ◽  
pp. S751-S751
Author(s):  
V. De Silva ◽  
A. Senanayake ◽  
S.S. Ratnatunga ◽  
S. Dissanayake ◽  
S. Gamage ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Ultra Sound ◽  
Control Group ◽  
Anti Psychotic ◽  
Androgenic Alopecia ◽  
Free T4 ◽  
Significant Difference ◽  
Ovarian Syndrome ◽  
Normal Controls

ObjectiveObjective was to compare the prevalence of probable polycystic ovarian syndrome (PCOS) in females treated with atypical anti-psychotics with normal controls.AimsTo compare the prevalence of PCOS in patients treated with atypical anti-psychotics and normal controls. To study the hormone profiles in these two groups.MethodsCases consisted of 102 reproductive age females with schizophrenia treated with atypical anti-psychotics for ≥6 months and had gained ≥10% body weight. Control group was 123 age and BMI matched females. Menstrual history, physical examination for hirsuitism, acne, androgenic alopecia, anthropometrics measures, Ultrasound abdomen and hormone analysis were done.ResultsMean age of cases = 33.17 years (SD 8.9) and controls = 33.08 years (SD 5.6). Mean BMI of cases = 25.92 (SD 5.2) and controls = 25.03 (SD 4.3). Polycystic ovarian morphology of ovaries on ultra sound scan was significantly more in cases 49 (48%) than controls 16 (13.%) (P < 0.001). Probable PCOS was significantly more in atypical anti-psychotic treated females (n = 22, 21.56%) than in normal controls (n = 10, 8.13%) (P = 0.04). Atypical anti-psychotic treated patients with PCOS had significantly lower mean LH levels 6.69 mIU/L than those without PCOS 10.30 (P = 0.35). There was no significant difference in testosterone, FSH, prolactin, TSH and free T4 levels.ConclusionTreatment with atypical anti-psychotics is associated with higher prevalence of PCOS. This has not been reported previously. The hormonal profile in these patients may be different with low testosterone and LH levels.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals A comparative study of thyroid stimulating hormone among lean and obese women with polycystic ovarian syndrome

2019 ◽  
Vol 8 (12) ◽  
pp. 4711
Author(s):  
Sangeetha M. C. ◽  
Suman Shivanagouda Patil ◽  
Nalini Arunkumar
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Thyroid Stimulating Hormone ◽  
Normal Weight ◽  
Reproductive Age ◽  
Obese Group ◽  
Obese Women ◽  
Significant Difference ◽  
Ovarian Syndrome ◽  
Serum Tsh ◽  
Tsh Levels

Background: The polycystic ovarian syndrome (PCOS) is an abnormality of young women of reproductive age. Between 20-50% of women with PCOS are normal weight or thin, and the pathophysiology of the disorder in these women may be related to a hypothalamic-pituitary defect that results in increased release of LH. PCOS and Thyroid disorders share certain common characteristics, risk factors, and pathophysiological abnormalities. In this study we have compared the serum TSH levels in obese and non-obese PCOS women to detect if there is a significant difference in the occurrence of hypothyroidism based on the BMI.Methods: Non-pregnant women attending the gynecological OPD diagnosed with PCOS as per Rotterdam criteria were included. Serum TSH was done in all women diagnosed as PCOS and based on their BMI women were either included in obese or non-obese group using Asian cut-off for BMI and the values compared.Results: In the present study 152 women were included. Women with low BMI and normal BMI were grouped as lean PCOS or non-obese PCOS and the overweight and obese women together were grouped as obese PCOS. The total number in the lean group was 28 and 124 in the obese group. Raised serum TSH levels were observed in 23.02%(35) women out of which 17.14%(6) belonged to the non-obese group and the remaining 82.85%(29) to the obese group. Among the 152 women thyroid enlargement was seen in 1.3%(2). Both women had raised serum TSH levels and both belonged to the obese group.Conclusions: The results of our study seem to indicate that thyroid dysfunction in PCOS women developed irrespective of presence or absence of obesity.

Sign in / Sign up

Export Citation Format

Share Document