High DHEAS in girls and metabolic features throughout pubertal maturation

2021 ◽  
Author(s):  
Ana Pereira ◽  
Paulina M. Merino ◽  
Jose L. Santos ◽  
German Iñiguez ◽  
Gordon B. Cutler ◽  
...  
Keyword(s):  
Pubertal Maturation

scholarly journals Pubertal Acceleration of Pulsatile Gonadotropin-Releasing Hormone Release in Male Rats as Revealed by Microdialysis

Endocrinology ◽  
2003 ◽  
Vol 144 (1) ◽  
pp. 163-171 ◽  
Author(s):  
Glenn C. Harris ◽  
Jon E. Levine
Keyword(s):  
Vas Deferens ◽  
Pulse Generator ◽  
Pulse Amplitude ◽  
Pulse Frequency ◽  
Male Rats ◽  
Male Rat ◽  
Pubertal Maturation ◽  
Repeated Sampling ◽  
Generator Activity ◽  
Mature Spermatozoa

Abstract A microdialysis technique was used in male rats to directly assess the postulate that pubertal maturation is associated with accelerated GnRH pulsatility. Juvenile male rats, postnatal d 43 or 45 (n = 4) were stereotaxically fitted with guide cannulas directed toward the lateral median eminence, and repeated microdialysis experiments were conducted over 4–6 d. In each session, samples were collected continuously over 12 h (0900–2100 h) at 5-min intervals Results from individual peripubertal animals were pooled into two time bins for postnatal d 45–47 and 48–50, respectively, and GnRH characteristics were compared between the two epochs. The GnRH pulse frequency and mean GnRH concentration were significantly elevated at 48–50 d compared with 45–47 d. The GnRH pulsatility characteristics for 45–47 d vs. 48–50 d were as follows: pulse frequency, 0.74 ± 0.16 vs. 1.79 ± 0.19 pulses/h (P < 0.05); pulse amplitude, 254.1 ± 22.3 vs. 347.2 ± 15.8 Δpg/ml (difference in value from trough to peak); and mean release, 0.55 ± 0.03 vs. 2.04 ± 0.04 pg/5 min (P < 0.05). An additional two rats were dialyzed only once on postnatal d 50 to assess the effects of repeated sampling; the GnRH pulse characteristics in these animals were similar to those in rats sampled for a third or fourth time on postnatal d 48–50. To further assess the possible effects of repeated sampling on GnRH release profiles, a group of adult male rats (postnatal d 95–105; n = 3) was also dialyzed on four consecutive days. In these rats no significant alteration in GnRH pulse generator activity was observed over the four sessions. Moreover, the increase in GnRH pulse frequency observed in the peripubertal rats was found to be sustained in adult animals. To better understand the temporal relationship of GnRH pulse generator activity to reproductive maturation, groups of male rats were killed from postnatal d 45–56 along with an adult group at 95–105 d (n = 5/group) and examined for physiological signs of reproductive development. Gradual increases in serum levels of LH and testosterone and decreases in FSH and inhibin B were seen from postnatal d 45–56 to adulthood. Mature spermatozoa were found in the vas deferens by postnatal d 53. Our results demonstrate that in the late juvenile stage of male rat development, GnRH pulse generator activity is gradually accelerated over the course of consecutive days. This acceleration occurs over a period during which serum LH and testosterone are rising to adult levels, and it precedes the presence of mature spermatozoa in the vas deferens by 3 d. Our observations provide direct support for the hypothesis that an acceleration of GnRH pulsatility is the critical neural stimulus for the initiation of pubertal maturation in males. The peripheral and central cues that prompt the pubertal activation of the GnRH pulse generator remain to be characterized.

scholarly journals Personal-accentuation and contextual-amplification models of pubertal timing: Predicting youth depression

2010 ◽  
Vol 22 (2) ◽  
pp. 433-451 ◽  
Author(s):  
Karen D. Rudolph ◽  
Wendy Troop-Gordon
Keyword(s):  
Stress Responses ◽  
Pubertal Timing ◽  
Pubertal Maturation ◽  
Maternal Caregivers ◽  
Developmental Transitions ◽  
Contextual Risk ◽  
Youth Depression ◽  
Key Characteristics ◽  
Semistructured Interviews ◽  
Contextual Risks

AbstractThis research examined personal-accentuation and contextual-amplification models of pubertal timing, wherein personal and contextual risks magnify the effects of earlier pubertal maturation on youth depression. A sample of 167 youths (M age = 12.41 years, SD = 1.19) and their maternal caregivers completed semistructured interviews and questionnaires at two waves. Consistent with a personal-accentuation model, earlier pubertal maturation more strongly predicted subsequent depression in youths with prior depression, certain personality traits, and maladaptive stress responses than in youths without these personal risks. Several of these effects were specific to earlier-maturing girls. Consistent with a contextual-amplification model, earlier pubertal maturation more strongly predicted subsequent depression in youths exposed to recent maternal depression and family stress than in youths without these contextual risks. These findings identify key characteristics of youths and their family context that help to explain individual variation in depressive reactions to earlier pubertal maturation. More broadly, this research contributes to integrative models of depression that consider the interplay among personal vulnerability, contextual risk, and developmental transitions.

The growth hormone response to pyridostigmine plus growth hormone releasing hormone is not influenced by pubertal maturation

1991 ◽  
Vol 14 (1) ◽  
pp. 41-45 ◽  
Author(s):  
M. Cappa ◽  
S. Loche ◽  
R. Salvatori ◽  
A. Faedda ◽  
P. Borrelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Response ◽  
Growth Hormone Releasing Hormone ◽  
Hormone Response ◽  
Pubertal Maturation ◽  
Releasing Hormone

Pubertal Maturation of the Gonadotropin Stimulatory Response to Clomiphene: Case Report

1971 ◽  
Vol 33 (3) ◽  
pp. 551-553 ◽  
Author(s):  
HOWARD E. KULIN ◽  
EDWARD O. REITER ◽  
WILLIAM E. BRIDSON
Keyword(s):  
Case Report ◽  
Pubertal Maturation

Pubertal maturation and time of day differentially affect behavioral and neuroendocrine responses following an acute stressor

2006 ◽  
Vol 50 (3) ◽  
pp. 463-468 ◽  
Author(s):  
Russell D. Romeo ◽  
Ilia N. Karatsoreos ◽  
Bruce S. McEwen
Keyword(s):  
Time Of Day ◽  
Pubertal Maturation ◽  
Neuroendocrine Responses ◽  
Acute Stressor

Effect of long-term growth hormone therapy on bone age and pubertal maturation in boys with and without classic growth hormone deficiency

1994 ◽  
Vol 125 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Z. Zadik ◽  
S. Chalew ◽  
A. Zung ◽  
H. Landau ◽  
E. Leiberman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Growth Hormone Deficiency ◽  
Growth Hormone Therapy ◽  
Bone Age ◽  
Hormone Deficiency ◽  
Pubertal Maturation

Negative influence of later pubertal maturation on bone integrity in healthy women is already determined in childhood

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S217
Author(s):  
T. Chevalley⁎ ◽  
J. Bonjour ◽  
S. Ferrari ◽  
R. Rizzoli
Keyword(s):  
Negative Influence ◽  
Pubertal Maturation ◽  
Healthy Women

Timing of pubertal development and midlife blood pressure in men and women: A Mendelian randomization study

2021 ◽  
Author(s):  
Io Ieong Chan ◽  
Man Ki Kwok ◽  
C Mary Schooling
Keyword(s):  
Blood Pressure ◽  
Mendelian Randomization ◽  
Association Studies ◽  
Pubertal Development ◽  
Sensitivity Analyses ◽  
Age At Menarche ◽  
Genome Wide Association Studies ◽  
Genetic Associations ◽  
Pubertal Maturation ◽  
Pubertal Growth

Abstract Introduction Observational studies suggest earlier puberty is associated with higher adulthood blood pressure (BP), but these findings have not been replicated using Mendelian randomization (MR). We examined this question sex-specifically using larger genome-wide association studies (GWAS) with more extensive measures of pubertal timing. Methods We obtained genetic instruments proxying pubertal maturation (age at menarche (AAM) or voice breaking (AVB)) from the largest published GWAS. We applied them to summary sex-specific genetic associations with systolic and diastolic BP z-scores, and self-reported hypertension in women (n=194174) and men (n=167020) from the UK Biobank, using inverse-variance weighting meta-analysis. We conducted sensitivity analyses using other MR methods, including multivariable MR adjusted for childhood obesity proxied by body mass index (BMI). We used late pubertal growth as a validation outcome. Results AAM (beta per one-year later = -0.030 [95% confidence interval (CI) -0.055, -0.005] and AVB (beta -0.058 [95% CI -0.100, -0.015]) were inversely associated with systolic BP independent of childhood BMI, as were diastolic BP (-0.035 [95% CI -0.060, -0.009] for AAM and -0.046 [95% CI -0.089, -0.004] for AVB) and self-reported hypertension (odds ratios 0.89 [95% CI 0.84, 0.95] for AAM and 0.87 [95% CI 0.79, 0.96] for AVB). AAM and AVB were positively associated with late pubertal growth, as expected. The results were robust to sensitivity analysis using other MR methods. Conclusion Timing of pubertal maturation was associated with adulthood BP independent of childhood BMI, highlighting the role of pubertal maturation timing in midlife BP.

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