The Thai reference exome (T‐REx) variant database

2021 ◽  
Author(s):  
Vorasuk Shotelersuk ◽  
Duangdao Wichadakul ◽  
Chumpol Ngamphiw ◽  
Chalurmpon Srichomthong ◽  
Chureerat Phokaew ◽  
...  
Keyword(s):  
Variant Database

scholarly journals Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Anthony P. West ◽  
Joel O. Wertheim ◽  
Jade C. Wang ◽  
Tetyana I. Vasylyeva ◽  
Jennifer L. Havens ◽  
...  
Keyword(s):  
New York ◽  
Viral Evolution ◽  
Software Tool ◽  
Neutralization Titer ◽  
The Public ◽  
Wide Scale ◽  
Health Relevance ◽  
Second Wave ◽  
Variant Database

AbstractWide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database (VDB), for quickly examining the changing landscape of spike mutations. Using VDB, we detect an emerging lineage of SARS-CoV-2 in the New York region that shares mutations with previously reported variants. The most common sets of spike mutations in this lineage (now designated as B.1.526) are L5F, T95I, D253G, E484K or S477N, D614G, and A701V. This lineage was first sequenced in late November 2020. Phylodynamic inference confirmed the rapid growth of the B.1.526 lineage. In concert with other variants, like B.1.1.7, the rise of B.1.526 appears to have extended the duration of the second wave of COVID-19 cases in NYC in early 2021. Pseudovirus neutralization experiments demonstrated that B.1.526 spike mutations adversely affect the neutralization titer of convalescent and vaccinee plasma, supporting the public health relevance of this lineage.

Open-Access Genomic Databases

2018 ◽  
Vol 48 (5) ◽  
pp. 659-672 ◽  
Author(s):  
Emmanuel Didier
Keyword(s):  
Open Access ◽  
Special Issue ◽  
Genomic Databases ◽  
Clinical Variant ◽  
The Government ◽  
Variant Database

A database organizes information, but since information is produced by actors, it also coordinates the different actors involved with data. Here, focusing on the newly created ClinVar, a genomic clinical variant database, we will see how it helps the government, academia, and industry (represented mainly by the company Illumina) find their positions relative to one another. This essay is part of a special issue entitled Histories of Data and the Database edited by Soraya de Chadarevian and Theodore M. Porter.

A novel genetic variant database for Korean native cattle (Hanwoo): HanwooGDB

2014 ◽  
Vol 37 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Kwondo Kim ◽  
Woori Kwak ◽  
Sam-Sun Sung ◽  
Seoae Cho ◽  
Heebal Kim ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Native Cattle ◽  
Variant Database

Development and first results of the BEAT-PCD international Primary Ciliary Dyskinesia gene variant database: CiliaVar

2021 ◽  
Author(s):  
Rahma Mani ◽  
Mafalda Gomes ◽  
Adrián Rodríguez González ◽  
Claire Hogg ◽  
Deborah Morris-Rosendahl ◽  
...  
Keyword(s):  
Primary Ciliary Dyskinesia ◽  
Gene Variant ◽  
First Results ◽  
Ciliary Dyskinesia ◽  
Variant Database

eMelanoBase: An online locus-specific variant database for familial melanoma

2002 ◽  
Vol 21 (1) ◽  
pp. 2-7 ◽  
Author(s):  
David C.Y. Fung ◽  
Elizabeth A. Holland ◽  
Therese M. Becker ◽  
Nicholas K. Hayward ◽  
Brigitte Bressac-de Paillerets ◽  
...  
Keyword(s):  
Familial Melanoma ◽  
Variant Database

Low-Density Lipoprotein Receptor Gene Familial Hypercholesterolemia Variant Database: Update and Pathological Assessment

2012 ◽  
Vol 76 (5) ◽  
pp. 387-401 ◽  
Author(s):  
Ebele Usifo ◽  
Sarah E. A. Leigh ◽  
Ros A. Whittall ◽  
Nicholas Lench ◽  
Alison Taylor ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Variant Database ◽  
Pathological Assessment

scholarly journals The UCL low-density lipoprotein receptor gene variant database: pathogenicity update

2016 ◽  
Vol 54 (4) ◽  
pp. 217-223 ◽  
Author(s):  
Sarah Leigh ◽  
Marta Futema ◽  
Ros Whittall ◽  
Alison Taylor-Beadling ◽  
Maggie Williams ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Gene Variant ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Variant Database

scholarly journals Bibliome Variant Database: Automated Identification and Annotation of Genetic Variants in Primary Literature

2020 ◽  
Author(s):  
Samuel W. Baker ◽  
Arupa Ganguly
Keyword(s):  
Human Genome ◽  
Genetic Variants ◽  
Gene Symbol ◽  
Reference Database ◽  
Variant Interpretation ◽  
Automated Identification ◽  
Primary Literature ◽  
Time Required ◽  
Variant Database ◽  
Gene Symbols

ABSTRACTThe Bibliome Variant Database (BVdb) is a freely available reference database containing over 1 million human genetic variants mapped to the human genome that have been mined from primary literature. The BVdb is designed to facilitate variant interpretation in clinical and research contexts by reducing or eliminating the time required to search for literature describing a given variant. Users can search the database using gene symbols, HGVS variant nomenclature, genomic positions, or rsIDs. Each variant page lists references in the database that describe the variant, as well as the exact gene symbol and variant text description identified in each reference.AVAILABILITY AND IMPLEMENTATIONThe BVdb is freely available at http://bibliome.ai

MANGANESE SOURCING AND TRANSPORT IN MASSACHUSETTS GROUNDWATER: UNDERSTANDING DISSOLUTION MECHANISMS AND CREATING A TEMPORALLY VARIANT DATABASE

2020 ◽  
Author(s):  
LeAnn X. Zuniga ◽  
◽  
David F. Boutt ◽  
Justin B. Richardson
Keyword(s):  
Variant Database

scholarly journals KRGDB: the large-scale variant database of 1722 Koreans based on whole genome sequencing

Database ◽  
2020 ◽  
Vol 2020 ◽  
Author(s):  
Kwang Su Jung ◽  
Kyung-Won Hong ◽  
Hyun Youn Jo ◽  
Jongpill Choi ◽  
Hyo-Jeong Ban ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Large Scale ◽  
Whole Genome ◽  
Variant Database
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