scholarly journals Effects of erythropoietin on tooth extraction socket healing in a mouse model of periodontitis

2019 ◽  
Vol 30 (S19) ◽  
pp. 110-110
Author(s):  
Sung‐Min Hwang ◽  
Ju‐Eun Bae ◽  
Yong‐Gun Kim ◽  
Jin‐Woo Park ◽  
Jae‐Mok Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tooth Extraction ◽  
Extraction Socket ◽  
Socket Healing

scholarly journals Effects of erythropoietin on tooth extraction socket healing in a mouse model of periodontitis

2019 ◽  
Author(s):  
Sung-Min Hwang ◽  
Jo-Young SUH ◽  
Kim Jae-Young ◽  
Bae Ju-Eun
Keyword(s):  
Mouse Model ◽  
Tooth Extraction ◽  
Extraction Socket ◽  
Socket Healing

scholarly journals Effects of pre-extraction intermittent PTH administration on extraction socket healing in bisphosphonate administered ovariectomized rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Young Kim ◽  
Hyo-Won Jang ◽  
Jung-In Kim ◽  
In-Ho Cha
Keyword(s):  
Tooth Extraction ◽  
Bisphosphonate Therapy ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Extraction Socket ◽  
Before And After ◽  
Socket Healing ◽  
Positive Effect

AbstractThe purpose of this study was to investigate the effect of administering intermittent parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of developing MRONJ in experimental animal model. Twenty-five ovariectomized rats received 6 weeks of bisphosphonate therapy. They were classified into 3 groups, based on the timing of the medication, as Control, Pre-PTH and Post-PTH groups. For Control group, normal saline was administered before and after tooth extraction. iPTH was administered during 4 weeks before tooth extraction for Pre-PTH group and after tooth extraction for Post-PTH group. The animals were euthanized 8 weeks after tooth extraction. Macroscopic, histological, micro-computed tomography (micro-CT), and histomorphometric examinations were conducted. The incidences of impaired healing were 11.11% both in Pre-PTH and Post-PTH groups, which was lower than the Control group (42.86%). Bone healing in the extraction socket, based on micro-CT and histomorphometry evaluations, was best in Post-PTH and worst in Control group. The Pre-PTH group showed moderate healing pattern. Despite of limitations in this study, the authors identified Pre-PTH group seems to have positive effect on extraction socket healing. With regard to timing, administering iPTH after tooth extraction was superior to applying it before tooth extraction.

scholarly journals Changes in PGE2 signaling after submandibulectomy alter post-tooth extraction socket healing

2018 ◽  
Vol 26 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Claudia Ester Mohn ◽  
Gastón Rodolfo Troncoso ◽  
Clarisa Bozzini ◽  
María Inés Conti ◽  
Javier Fernandez Solari ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Extraction Socket ◽  
Socket Healing

scholarly journals Intra-oral PTH Administration Promotes Tooth Extraction Socket Healing

2013 ◽  
Vol 92 (6) ◽  
pp. 553-559 ◽  
Author(s):  
S. Kuroshima ◽  
B.L. Kovacic ◽  
K.M. Kozloff ◽  
L.K. McCauley ◽  
J. Yamashita
Keyword(s):  
Tooth Extraction ◽  
Extraction Socket ◽  
Socket Healing

Tooth Extraction Socket Healing in Pediatric Patients Treated with Intravenous Pamidronate

2008 ◽  
Vol 153 (5) ◽  
pp. 719-720 ◽  
Author(s):  
Carol Chahine ◽  
Moira S. Cheung ◽  
Timothy W. Head ◽  
Stéphane Schwartz ◽  
Francis H. Glorieux ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Pediatric Patients ◽  
Extraction Socket ◽  
Intravenous Pamidronate ◽  
Socket Healing

Method for quantitative assessment of surgical wound healing (for example, the hole of a removed tooth). Part I

2020 ◽  
Vol 25 (4) ◽  
pp. 349-356
Author(s):  
M. V. Lomakin ◽  
I. I. Soloshchanskii ◽  
A. A. Pokhabov ◽  
H. U. Bisultanov
Keyword(s):  
Wound Healing ◽  
Success Rate ◽  
Quantitative Assessment ◽  
Tooth Extraction ◽  
Healing Process ◽  
Real Life ◽  
Surgical Wound ◽  
Extraction Socket ◽  
Radiographic Findings ◽  
Socket Healing

Relevance. Surgical stages of the dental implant restoration are an indispensable part of the treatment procedures. However, underestimation of residual/ available alveolar bone volume after tooth extraction may challenge implantation planning. Socket healing process might depend on either a surgical technique, or local or systemic preexisting factors, that this study should present as quantitative data. Purpose is to develop a technique for quantitative assessment of a surgical wound healing, e.g. an extraction socket.Materials and methods. The study included 42 patients after extraction of different teeth during the preparatory procedures for further dental arch restoration with implants. Follow-ups, clinical data, laboratory and radiographic findings determined clinical, radiographic, and information values – dependent and independent variables as quantifiable clinical parameters – biomarkers; they were statistically analyzed.Results. The conducted analysis revealed correlation dependence between selected parameters. Highly significant interrelationship allowed calculating the overall success rate of wound/ socket healing after tooth extraction. A regression model was developed to explain 76% healing success rate.Conclusion. Thus, factors and conditions determining the healing of a surgical bone wound, e.g. an extraction socket, consistently affect each other. Numerical sequences of real-life processes characterize the extent and highly significant interrelations and allow predicting the mutual impact of the factors.

scholarly journals Maresin 1 Promotes Wound Healing and Socket Bone Regeneration for Alveolar Ridge Preservation

2020 ◽  
Vol 99 (8) ◽  
pp. 930-937 ◽  
Author(s):  
C.W. Wang ◽  
S.H. Yu ◽  
T. Fretwurst ◽  
L. Larsson ◽  
J.V. Sugai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Postoperative Pain ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Lipid Mediator ◽  
Preclinical Model ◽  
Alveolar Ridge ◽  
Extraction Socket ◽  
Socket Healing ◽  
Maresin 1

Tooth extraction results in alveolar bone resorption and is accompanied by postoperative swelling and pain. Maresin 1 (MaR1) is a proresolving lipid mediator produced by macrophages during the resolution phase of inflammation, bridging healing and tissue regeneration. The aim of this study was to examine the effects of MaR1 on tooth extraction socket wound healing in a preclinical rat model. The maxillary right first molars of Sprague-Dawley rats were extracted, and gelatin scaffolds were placed into the sockets with or without MaR1. Topical application was also given twice a week until complete socket wound closure up to 14 d. Immediate postoperative pain was assessed by 3 scores. Histology and microcomputed tomography were used to assess socket bone fill and alveolar ridge dimensional changes at selected dates. The assessments of coded specimens were performed by masked, calibrated examiners. Local application of MaR1 potently accelerated extraction socket healing. Macroscopic and histologic analysis revealed a reduced soft tissue wound opening and more rapid re-epithelialization with MaR1 delivery versus vehicle on socket healing. Under micro–computed tomography analysis, MaR1 (especially at 0.05 μg/μL) stimulated greater socket bone fill at day 10 as compared with the vehicle-treated animals, resulting in less buccal plate resorption and a wider alveolar ridge by day 21. Interestingly, an increased ratio of CD206+:CD68+ macrophages was identified in the sockets with MaR1 application under immunohistochemistry and immunofluorescence analysis. As compared with the vehicle therapy, local delivery of MaR1 reduced immediate postoperative surrogate pain score panels. In summary, MaR1 accelerated extraction wound healing, promoted socket bone fill, preserved alveolar ridge bone, and reduced postoperative pain in vivo with a rodent preclinical model. Local administration of MaR1 offers clinical potential to accelerate extraction socket wound healing for more predictable dental implant reconstruction.

Effect of anti-angiogenesis induced by chemotherapeutic monotherapy, chemotherapeutic/bisphosphonate combination therapy and anti-VEGFA mAb therapy on tooth extraction socket healing in mice

2017 ◽  
Vol 36 (5) ◽  
pp. 547-559 ◽  
Author(s):  
Yuri Akita ◽  
Shinichiro Kuroshima ◽  
Kazunori Nakajima ◽  
Hiroki Hayano ◽  
Riho Kanai ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Tooth Extraction ◽  
Extraction Socket ◽  
Socket Healing
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