A decrease in serum 1,5-anhydroglucitol levels is associated with the presence of a first-degree family history of diabetes in a Chinese population with normal glucose tolerance

2017 ◽  
Vol 35 (1) ◽  
pp. 131-136 ◽  
Author(s):  
X. Hu ◽  
X. He ◽  
X. Ma ◽  
H. Su ◽  
L. Ying ◽  
...  
Keyword(s):  
Family History ◽  
Glucose Tolerance ◽  
Chinese Population ◽  
Normal Glucose Tolerance ◽  
Family History Of Diabetes ◽  
Normal Glucose ◽  
History Of

scholarly journals High frequency of antithyroid autoantibodies in pregnant women at increased risk of gestational diabetes mellitus

2000 ◽  
pp. 741-747 ◽  
Author(s):  
A Olivieri ◽  
H Valensise ◽  
F Magnani ◽  
E Medda ◽  
S De Angelis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Glucose Tolerance ◽  
Pregnant Women ◽  
Thyroid Function ◽  
Positive Family History ◽  
Normal Glucose Tolerance ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
History Of

BACKGROUND: Thyroid autoantibodies (ThyAb) and subclinical hypothyroidism occur more frequently in pregnant women with insulin-dependent diabetes mellitus than in healthy pregnant women. Few studies have investigated the presence of ThyAb in women with gestational diabetes mellitus (GDM), and no significant association between diabetes in pregnancy and thyroid function has been reported. OBJECTIVE: To assess the thyroid biochemical profile and estimate the prevalence of ThyAb in a group of pregnant women at increased risk of GDM due to family and personal risk factors, and to investigate the relationship between a positive family history of diabetes or thyroid diseases and the eventual presence of ThyAb during pregnancy. METHODS: Oral glucose tolerance, serum ThyAb and thyroid function were evaluated in 181 pregnant women with increased risk for GDM (study group). Seventeen healthy pregnant women without risk factors for GDM and with a normal glucose tolerance were recruited as controls. RESULTS: The women who developed GDM showed a mean free thyroxine concentration significantly lower than that observed in the healthy pregnant women and in those with impaired gestational glucose tolerance and normal glucose tolerance. Twenty-nine of the 181 women in the study group (16%) were ThyAb positive. However, the risk of being ThyAb positive during pregnancy was three times greater in the women with positive family history of both diabetes mellitus and thyroid disease than in those with no family history of these conditions. CONCLUSIONS: This study showed that women with increased risk of GDM, mostly those with family history of diabetes mellitus and thyroid disease, also have an increased risk of being ThyAb positive during pregnancy. It also highlighted the importance of evaluating thyroid function in pregnant women with impaired glucose tolerance, in view of their increased risk of subclinical hypothyroidism.

scholarly journals Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Alice S. Ryan
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Older Women ◽  
Inflammatory Markers ◽  
Normal Glucose Tolerance ◽  
Diet And Exercise ◽  
Normal Glucose ◽  
History Of

The purpose of this study was to compare systemic inflammation in older women with a history of gestational diabetes (GDM) who developed impaired glucose tolerance (IGT) or type 2 diabetes (T2DM) to that in those with normal glucose tolerance (NGT) and to determine, in these women, the effect of weight loss (WL) induced by diet and exercise training on systemic inflammation and adipokine levels. This was a longitudinal clinical investigation of overweight/obese (BMI: 32 ± 1 kg/m2) women (59 ± 1 years) with a GDM history (n=19) who had normal glucose tolerance (NGT, n=7) or IGT/T2DM (n=12). Women completed 6 months of weight loss induced by diet and exercise and underwent VO2max, body composition, blood draw, glucose tolerance testing, and 2-hour hyperinsulinemic-euglycemic clamps (40 mU·m−2·min−1). Glucose utilization (M) was 42% higher in the NGT group (P<0.05). CRP was two-fold higher in the IGT/T2DM group than that in the NGT group (P<0.01). Adiponectin levels were 59% higher in the NGT group than those in the IGT/T2DM group (P<0.01). IL-6sR was higher in the NGT group (P<0.01). The women lost body weight, body fat, visceral fat, and subcutaneous abdominal fat (P<0.001). Fasting glucose (P<0.05), fasting insulin, glucose, and insulin AUC decreased (all P<0.005) after the intervention. M increased by 21% (P<0.05). CRP (−16%) and TNFR1 (−6%) tended to decrease, whereas TNFα, IL-6, SAA, and adiponectin did not change in the group. In conclusion, older women with a history of GDM who have developed IGT or T2DM have higher CRP and reduced adiponectin levels despite similar BMI and total and abdominal obesity to those with NGT. Six months WL induced by diet and exercise improves body composition and increases insulin sensitivity without a significant modification of inflammatory markers and adiponectin levels.

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