scholarly journals Persistence of oral antidiabetic treatment for type 2 diabetes characterized by drug class, patient characteristics and severity of renal impairment: A Japanese database analysis

2018 ◽  
Vol 20 (12) ◽  
pp. 2830-2839 ◽  
Author(s):  
Takashi Kadowaki ◽  
Nobuaki Sarai ◽  
Takeshi Hirakawa ◽  
Kentaro Taki ◽  
Kosuke Iwasaki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Impairment ◽  
Drug Class ◽  
Patient Characteristics ◽  
Database Analysis ◽  
Antidiabetic Treatment ◽  
Oral Antidiabetic

scholarly journals Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Takeshi Horii ◽  
Makiko Iwasawa ◽  
Yusuke Kabeya ◽  
Koichiro Atuda
Keyword(s):  
Type 2 Diabetes ◽  
Medication Adherence ◽  
Patient Characteristics ◽  
Factors Associated ◽  
Antidiabetic Treatment ◽  
Proportion Of Days Covered ◽  
Hypoglycaemic Agent ◽  
Poor Medication Adherence ◽  
Observation Period

Abstract Polypharmacy (PP) occurs in patients with type 2 diabetes (T2DM) owing to multimorbidity. We evaluated concomitant PP and medication adherence in T2DM 3 years after initiation of administration of a hypoglycaemic agent using a nationwide claim-based database in Japan. Factors associated with medication PP and imperfect adherence were identified using multivariable logistic regression. PP was defined as using ≥6 medications. Patients with proportion of days covered (PDC) of <80% were defined as having poor medication adherence. A total of 884 patients were analysed. Multivariate analysis revealed that age, total number of consultations and body mass index (BMI) are factors that influence PP. Factors associated with PDC < 80% were 2–3, 4–5 and ≥ 6 medications compared with 1 medication, male sex, <17 consultations and age 50–59 and ≥ 60 years compared with <40 years. In conclusion, older age, high total number of consultations and BMI ≥ 25 kg/m2 are risk factors for PP. PP influenced good medication adherence at the end of the observation period.

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